Sökning: WFRF:(Doyle Karen M) > (2021) > Per-pass analysis o...
Fältnamn | Indikatorer | Metadata |
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000 | 06276naa a2200685 4500 | |
001 | oai:gup.ub.gu.se/304900 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3049002 URI |
024 | 7 | a https://doi.org/10.1136/neurintsurg-2020-0169662 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fitzgerald, Seán4 aut |
245 | 1 0 | a Per-pass analysis of acute ischemic stroke clots: impact of stroke etiology on extracted clot area and histological composition. |
264 | c 2020-12-09 | |
264 | 1 | b BMJ,c 2021 |
520 | a Initial studies investigating correlations between stroke etiology and clot composition are conflicting and do not account for clot size as determined by area. Radiological studies have shown that cardioembolic strokes are associated with shorter clot lengths and lower clot burden than non-cardioembolic clots.To report the relationship between stroke etiology, extracted clot area, and histological composition at each procedural pass.As part of the multi-institutional RESTORE Registry, the Martius Scarlett Blue stained histological composition and extracted clot area of 612 per-pass clots retrieved from 441 patients during mechanical thrombectomy procedures were quantified. Correlations with clinical and procedural details were investigated.Clot composition varied significantly with procedural passes; clots retrieved in earlier passes had higher red blood cell content (H4=11.644, p=0.020) and larger extracted clot area (H4=10.730, p=0.030). Later passes were associated with significantly higher fibrin (H4=12.935, p=0.012) and platelets/other (H4=15.977, p=0.003) content and smaller extracted clot area. Large artery atherosclerotic (LAA) clots were significantly larger in the extracted clot area and more red blood cell-rich than other etiologies in passes 1-3. Cardioembolic and cryptogenic clots had similar histological composition and extracted clot area across all procedural passes.LAA clots are larger and associated with a large red blood cell-rich extracted clot area, suggesting soft thrombus material. Cardioembolic clots are smaller in the extracted clot area, consistent in composition and area across passes, and have higher fibrin and platelets/other content than LAA clots, making them stiffer clots. The per-pass histological composition and extracted clot area of cryptogenic clots are similar to those of cardioembolic clots, suggesting similar formation mechanisms. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
700 | 1 | a Rossi, Rosanna4 aut |
700 | 1 | a Mereuta, Oana Madalina4 aut |
700 | 1 | a Jabrah, Duaa4 aut |
700 | 1 | a Okolo, Adaobi4 aut |
700 | 1 | a Douglas, Andrew4 aut |
700 | 1 | a Molina Gil, Sara4 aut |
700 | 1 | a Pandit, Abhay4 aut |
700 | 1 | a McCarthy, Ray4 aut |
700 | 1 | a Gilvarry, Michael4 aut |
700 | 1 | a Dunker, Dennisu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology4 aut |
700 | 1 | a Nordanstig, Annika,d 1974u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xnoraz |
700 | 1 | a Ceder, Eriku Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology4 aut |
700 | 1 | a Redfors, Petrau Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xredpe |
700 | 1 | a Jood, Katarina,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xjooka |
700 | 1 | a Dehlfors, Niclasu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology4 aut |
700 | 1 | a Magoufis, Georgios4 aut |
700 | 1 | a Tsivgoulis, Georgios4 aut |
700 | 1 | a Brinjikji, Waleed4 aut |
700 | 1 | a Kallmes, David F4 aut |
700 | 1 | a O'Hare, Alan4 aut |
700 | 1 | a Power, Sarah4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Alderson, Jack4 aut |
700 | 1 | a Nagy, András4 aut |
700 | 1 | a Vadász, Ágnes4 aut |
700 | 1 | a Psychogios, Klearchos4 aut |
700 | 1 | a Szikora, Istvan4 aut |
700 | 1 | a Tatlisumak, Turgutu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xtatlt |
700 | 1 | a Rentzos, Alexandros,d 1979u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiologi,Institute of Clinical Sciences, Department of Radiology4 aut0 (Swepub:gu)xrenta |
700 | 1 | a Thornton, John4 aut |
700 | 1 | a Doyle, Karen M4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för radiologi4 org |
773 | 0 | t Journal of neurointerventional surgeryd : BMJg 13, s. 1111-1116q 13<1111-1116x 1759-8486x 1759-8478 |
856 | 4 | u https://jnis.bmj.com/content/neurintsurg/early/2021/05/06/neurintsurg-2020-016966.full.pdf |
856 | 4 8 | u https://gup.ub.gu.se/publication/304900 |
856 | 4 8 | u https://doi.org/10.1136/neurintsurg-2020-016966 |
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