Sökning: WFRF:(Dukat Andre) > Liver Tests and Out...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04772naa a2200721 4500 | |
001 | oai:DiVA.org:uu-512636 | |
003 | SwePub | |
008 | 240522s2022 | |||||||||||000 ||eng| | |
009 | oai:gup.ub.gu.se/318234 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5126362 URI |
024 | 7 | a https://doi.org/10.1002/ejhf.26492 DOI |
024 | 7 | a https://gup.ub.gu.se/publication/3182342 URI |
040 | a (SwePub)uud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Adamson, Carly4 aut |
245 | 1 0 | a Liver Tests and Outcomes in Heart Failure with Reduced Ejection Fraction :b Findings from DAPA-HF. |
264 | c 2022-08-22 | |
264 | 1 | b Wiley,c 2022 |
338 | a print2 rdacarrier | |
520 | a AIMS: Reflecting both increased venous pressure and reduced cardiac output, abnormal liver tests are common in patients with severe heart failure and are associated with adverse clinical outcomes. We aimed to investigate the prognostic significance of abnormal liver tests in ambulatory patients with heart failure with reduced ejection fraction (HFrEF), explore any treatment interaction between bilirubin and sodium- glucose cotransporter 2 (SGLT2) inhibitors and examine change in liver tests with SGLT2 inhibitor treatment. METHODS AND RESULTS: We explored these objectives in the Dapagliflozin And Prevention of Adverse outcomes in Heart Failure (DAPA-HF) trial, with focus on bilirubin. We calculated the incidence of cardiovascular death or worsening heart failure by bilirubin tertile. Secondary cardiovascular outcomes were examined, along with the change in liver tests at the end-of-study visit. Baseline bilirubin was available in 4720 patients (99.5%). Participants in the highest bilirubin tertile (T3) have more severe HFrEF (lower left ventricular ejection fraction, higher N-terminal pro-B-type natriuretic peptide [NT-proBNP] and worse New York Heart Association class), had a greater burden of atrial fibrillation but less diabetes. Higher bilirubin (T3 vs. T1) was associated with worse outcomes even after adjustment for other predictive variables, including NT-proBNP and troponin T (adjusted hazard ratio for the primary outcome 1.73 [95% confidence interval 1.37-2.17], p $<$ 0.001; and 1.52 [1.12-2.07], p = 0.01 for cardiovascular death). Baseline bilirubin did not modify the benefits of dapagliflozin. During follow-up, dapagliflozin had no effect on liver tests. CONCLUSION: Bilirubin concentration was an independent predictor of worse outcomes but did not modify the benefits of dapagliflozin in HFrEF. Dapagliflozin was not associated with change in liver tests. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT03036124. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a *Heart Failure | |
653 | a Alkaline phosphatase | |
653 | a Bilirubin | |
653 | a Dapagliflozin | |
653 | a Heart failure | |
653 | a Hepatic function | |
653 | a Humans | |
653 | a Liver | |
653 | a SGLT2 inhibitor | |
653 | a Stroke Volume | |
653 | a Ventricular Function | |
653 | a Left | |
700 | 1 | a Cowan, Lorna M.4 aut |
700 | 1 | a de Boer, Rudolf A.4 aut |
700 | 1 | a Diez, Mirta4 aut |
700 | 1 | a Drozdz, Jaroslaw4 aut |
700 | 1 | a Dukat, Andre4 aut |
700 | 1 | a Inzucchi, Silvio E.4 aut |
700 | 1 | a Kober, Lars4 aut |
700 | 1 | a Kosiborod, Mikhail N.4 aut |
700 | 1 | a Ljungman, Charlotta,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xljcha |
700 | 1 | a Martinez, Felipe A.4 aut |
700 | 1 | a Ponikowski, Piotr4 aut |
700 | 1 | a Sabatine, Marc S.4 aut |
700 | 1 | a Lindholm, Daniel4 aut |
700 | 1 | a Bengtsson, Olof4 aut |
700 | 1 | a Boulton, David W.4 aut |
700 | 1 | a Greasley, Peter J.4 aut |
700 | 1 | a Langkilde, Anna Maria4 aut |
700 | 1 | a Sjostrand, Mikaela4 aut |
700 | 1 | a Solomon, Scott D.4 aut |
700 | 1 | a McMurray, John J. V.4 aut |
700 | 1 | a Jhund, Pardeep S.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
773 | 0 | t European journal of heart failured : Wileyg 24:10, s. 1856-1868q 24:10<1856-1868x 1388-9842x 1879-0844 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-512636 |
856 | 4 8 | u https://doi.org/10.1002/ejhf.2649 |
856 | 4 8 | u https://gup.ub.gu.se/publication/318234 |
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