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Liver nucleotide bi...
Liver nucleotide biosynthesis is linked to protection from vascular complications in individuals with long-term type 1 diabetes
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- Jain, Ruchi (författare)
- Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
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- Ozgumus, T. (författare)
- University of Bergen
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- Jensen, T. M. (författare)
- University of Southern Denmark,Steno Diabetes Center Copenhagen
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- du Plessis, E. (författare)
- University of Bergen
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- Keindl, M. (författare)
- University of Bergen
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- Moller, C. L. (författare)
- Steno Diabetes Center Copenhagen
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- Falhammar, H. (författare)
- Karolinska Institutet
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- Nystrom, T. (författare)
- Karolinska Institutet,Stockholm South General Hospital
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- Catrina, S. B. (författare)
- Karolinska Institutet,Akademiskt specialistcentrum, Stockholm,Karolinska University Hospital
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- Jorneskog, G. (författare)
- Karolinska Institutet,Danderyd Hospital
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- Jessen, L. E. (författare)
- Technical University of Denmark
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- Forsblom, C. (författare)
- Folkhälsan Research Center,University of Helsinki,Helsinki University Central Hospital
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- Haukka, J. K. (författare)
- Helsinki University Central Hospital,Helsinki University of Technology,Folkhälsan Research Center
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- Groop, P. H. (författare)
- Monash University,Folkhälsan Research Center,University of Helsinki,Helsinki University Central Hospital
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- Rossing, P. (författare)
- University of Copenhagen,Steno Diabetes Center Copenhagen
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki,Institute for Molecular Medicine Finland (FIMM)
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- Eliasson, Mats (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin
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- Eliasson, Björn, 1959 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Brismar, K. (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Al-Majdoub, Mahmoud (författare)
- Lund University,Lunds universitet,Diabetes - molekylär metabolism,Forskargrupper vid Lunds universitet,Diabetes - Molecular Metabolism,Lund University Research Groups
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- Nilsson, Peter M. (författare)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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- Taskinen, M. R. (författare)
- University of Helsinki
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- Ferrannini, E. (författare)
- CNR Institute of Clinical Physiology (IFC-CNR)
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- Spégel, Peter (författare)
- Lund University,Lunds universitet,Centrum för analys och syntes,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Centre for Analysis and Synthesis,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Berg, T. J. (författare)
- University of Oslo,Oslo university hospital
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- Lyssenko, Valeriya (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Bergen
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(creator_code:org_t)
- 2020-07-14
- 2020
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
- Relaterad länk:
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https://www.nature.c...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Identification of biomarkers associated with protection from developing diabetic complications is a prerequisite for an effective prevention and treatment. The aim of the present study was to identify clinical and plasma metabolite markers associated with freedom from vascular complications in people with very long duration of type 1 diabetes (T1D). Individuals with T1D, who despite having longer than 30 years of diabetes duration never developed major macro- or microvascular complications (non-progressors; NP) were compared with those who developed vascular complications within 25 years from diabetes onset (rapid progressors; RP) in the Scandinavian PROLONG (n = 385) and DIALONG (n = 71) cohorts. The DIALONG study also included 75 healthy controls. Plasma metabolites were measured using gas and/or liquid chromatography coupled to mass spectrometry. Lower hepatic fatty liver indices were significant common feature characterized NPs in both studies. Higher insulin sensitivity and residual beta-cell function (C-peptide) were also associated with NPs in PROLONG. Protection from diabetic complications was associated with lower levels of the glycolytic metabolite pyruvate and APOCIII in PROLONG, and with lower levels of thiamine monophosphate and erythritol, a cofactor and intermediate product in the pentose phosphate pathway as well as higher phenylalanine, glycine and serine in DIALONG. Furthermore, T1D individuals showed elevated levels of picolinic acid as compared to the healthy individuals. The present findings suggest a potential beneficial shunting of glycolytic substrates towards the pentose phosphate and one carbon metabolism pathways to promote nucleotide biosynthesis in the liver. These processes might be linked to higher insulin sensitivity and lower liver fat content, and might represent a mechanism for protection from vascular complications in individuals with long-term T1D.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Jain, Ruchi
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Ozgumus, T.
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Jensen, T. M.
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du Plessis, E.
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Keindl, M.
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Moller, C. L.
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visa fler...
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Falhammar, H.
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Nystrom, T.
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Catrina, S. B.
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Jorneskog, G.
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Jessen, L. E.
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Forsblom, C.
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Haukka, J. K.
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Groop, P. H.
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Rossing, P.
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Groop, Leif
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Eliasson, Mats
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Eliasson, Björn, ...
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Brismar, K.
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Al-Majdoub, Mahm ...
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Nilsson, Peter M ...
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Taskinen, M. R.
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Ferrannini, E.
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Spégel, Peter
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Berg, T. J.
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Lyssenko, Valeri ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Scientific Repor ...
- Av lärosätet
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Göteborgs universitet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet