Sökning: WFRF:(Emilsson Össur Ingi)
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Association between...
Association between lung function decline and obstructive sleep apnoea: the ALEC study
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- Emilsson, Össur Ingi (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Sundbom, Fredrik (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Ljunggren, Mirjam (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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Benediktsdottir, B. (författare)
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Garcia-Aymerich, J. (författare)
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Bui, D. S. (författare)
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Jarvis, D. (författare)
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- Olin, Anna-Carin, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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- Franklin, Karl A. (författare)
- Umeå universitet,Kirurgi
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Demoly, P. (författare)
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- Lindberg, Eva (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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Aspelund, T. (författare)
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Gislason, T. (författare)
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(creator_code:org_t)
- 2020-07-06
- 2021
- Engelska.
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Ingår i: Sleep and Breathing. - : Springer Science and Business Media LLC. - 1520-9512 .- 1522-1709. ; 25, s. 587-596
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Purpose To study changes in lung function among individuals with a risk of obstructive sleep apnoea (OSA), and if asthma affected this relationship. Methods We used data from the European Community Respiratory Health Survey II and III, a multicentre general population study. Participants answered questionnaires and performed spirometry at baseline and 10-year follow-up (n= 4,329 attended both visits). Subjects with high risk for OSA were identified from the multivariable apnoea prediction (MAP) index, calculated from BMI, age, gender, and OSA symptoms at follow-up. Asthma was defined as having doctor's diagnosed asthma at follow-up. Primary outcomes were changes in forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from baseline to follow-up. Results Among 5108 participants at follow-up, 991 (19%) had a high risk of OSA based on the MAP index. Participants with high OSA risk more often had wheeze, cough, chest tightness, and breathlessness at follow-up than those with low OSA risk. Lung function declined more rapidly in subjects with high OSA risk (low vs high OSA risk [mean +/- SD]: FEV1 = - 41.3 +/- 24.3 ml/year vs - 50.8 +/- 30.1 ml/year; FVC = - 30.5 +/- 31.2 ml/year vs - 45.2 +/- 36.3 ml/year). Lung function decline was primarily associated with higher BMI and OSA symptoms. OSA symptoms had a stronger association with lung function decline among asthmatics, compared to non-asthmatics. Conclusion In the general population, a high probability of obstructive sleep apnoea was related to faster lung function decline in the previous decade. This was driven by a higher BMI and more OSA symptoms among these subjects. The association between OSA symptoms and lung function decline was stronger among asthmatics.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Sleep apnoea
- Lung function
- Lung function decline
- Asthma
- daytime sleepiness
- young-adults
- population
- asthma
- epidemiology
- inflammation
- pressure
- index
- women
- Neurosciences & Neurology
- Respiratory System
- Sleep apnoea
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Emilsson, Össur ...
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Sundbom, Fredrik
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Ljunggren, Mirja ...
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Benediktsdottir, ...
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Garcia-Aymerich, ...
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Bui, D. S.
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Jarvis, D.
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Olin, Anna-Carin ...
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Franklin, Karl A ...
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Demoly, P.
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Lindberg, Eva
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Janson, Christer
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Aspelund, T.
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Gislason, T.
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