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WFRF:(Ericsson Johanna 1978)
 

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005021naa a2200685 4500
001oai:gup.ub.gu.se/50354
003SwePub
008240528s2006 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/503542 URI
0247 a https://doi.org/10.1194/jlr.M500424-JLR2002 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Li, Lu,d 1964u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xlilui
2451 0a Epigallocatechin gallate increases the formation of cytosolic lipid droplets and decreases the secretion of apoB-100 VLDL
264 1c 2006
520 a Epigallocatechin gallate (EGCG) increases the formation of cytosolic lipid droplets by a mechanism that is independent of the rate of triglyceride biosynthesis and involves an enhanced fusion between lipid droplets, a process that is crucial for their growth in size. EGCG treatment reduced the secretion of both triglycerides and apolipoprotein B-100 (apoB-100) VLDLs but not of transferrin, albumin, or total proteins, indicating that EGCG diverts triglycerides from VLDL assembly to storage in the cytosol. This is further supported by the observed increase in both intracellular degradation of apoB-100 and ubiquitination of the protein (indicative of increased proteasomal degradation) in EGCG-treated cells. EGCG did not interfere with the microsomal triglyceride transfer protein, and the effect of EGCG on the secretion of VLDLs was found to be independent of the LDL receptor. Thus, our results indicate that EGCG promotes the accumulation of triglycerides in cytosolic lipid droplets, thereby diverting lipids from the assembly of VLDL to storage in the cytosol. Our results also indicate that the accumulation of lipids in the cytosol is not always associated with increased secretion of VLDL.
653 a Adipocytes/drug effects/metabolism
653 a Animals
653 a Apolipoprotein B-100
653 a Apolipoproteins B/genetics/*metabolism
653 a Base Sequence
653 a Catechin/*analogs & derivatives/pharmacology
653 a Cell Line
653 a Cytosol/drug effects/metabolism
653 a DNA
653 a Complementary/genetics
653 a Heparin/pharmacology
653 a Humans
653 a Lipid Metabolism/*drug effects
653 a Lipids/blood
653 a Lipoproteins/blood
653 a Lipoproteins
653 a VLDL/*metabolism
653 a Membrane Proteins/genetics/metabolism
653 a Mice
653 a Mice
653 a Transgenic
653 a NIH 3T3 Cells
653 a Rats
653 a Receptors
653 a LDL/drug effects/metabolism
653 a Recombinant Proteins/genetics/metabolism
7001 a Stillemark-Billton, Pia,d 1968u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xstipi
7001 a Beck, Caroline,d 1976u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xbecca
7001 a Boström, Pontus,d 1982u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xbospo
7001 a Andersson, Linda,d 1973u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xanlin
7001 a Rutberg, Mikael,d 1959u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xrutmi
7001 a Ericsson, Johanna,d 1978u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut
7001 a Magnusson, Björn,d 1976u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xmagnb
7001 a Marchesan, Denis,d 1968u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut
7001 a Ljungberg, Anna,d 1977u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology4 aut0 (Swepub:gu)xljuan
7001 a Borén, Jan,d 1963u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Wallenberglaboratoriet,Institute of Medicine, Department of Molecular and Clinical Medicine,Wallenberg Laboratory4 aut0 (Swepub:gu)xborej
7001 a Olofsson, Sven-Olof,d 1947u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xolosv
7102 a Göteborgs universitetb Wallenberglaboratoriet4 org
7730 t J Lipid Resg 47:1, s. 67-77q 47:1<67-77x 0022-2275
8564 8u https://gup.ub.gu.se/publication/50354
8564 8u https://doi.org/10.1194/jlr.M500424-JLR200

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