Exploring the genetics of lithium response in bipolar disorders.

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Fältnamn	Indikatorer	Metadata
000		08446nam a2201741 4500
001		oai:gup.ub.gu.se/333382
003		SwePub
008		240528s2023 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:238077040
024	7	a https://gup.ub.gu.se/publication/3333822 URI
024	7	a https://doi.org/10.21203/rs.3.rs-3677630/v12 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:2380770402 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a ovr2 swepub-publicationtype
100	1	a Herrera-Rivero, Marisol4 aut
245	1 0	a Exploring the genetics of lithium response in bipolar disorders.
264	1	c 2023
520		a Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have beneficial effects on disease-associated conditions, including sleep and cardiovascular disorders. However, the individual responses to Li treatment vary within and between diagnostic subtypes of BP (e.g. BP-I and BP-II) according to the clinical presentation. Moreover, long-term Li treatment has been linked to adverse side-effects that are a cause of concern and non-adherence, including the risk of developing chronic medical conditions such as thyroid and renal disease. In recent years, studies by the Consortium on Lithium Genetics (ConLiGen) have uncovered a number of genetic factors that contribute to the variability in Li treatment response in patients with BP. Here, we leveraged the ConLiGen cohort (N=2,064) to investigate the genetic basis of Li effects in BP. For this, we studied how Li response and linked genes associate with the psychiatric symptoms and polygenic load for medical comorbidities, placing particular emphasis on identifying differences between BP-I and BP-II.We found that clinical response to Li treatment, measured with the Alda scale, was associated with a diminished burden of mania, depression, substance and alcohol abuse, psychosis and suicidal ideation in patients with BP-I and, in patients with BP-II, of depression only. Our genetic analyses showed that a stronger clinical response to Li was modestly related to lower polygenic load for diabetes and hypertension in BP-I but not BP-II. Moreover, our results suggested that a number of genes that have been previously linked to Li response variability in BP differentially relate to the psychiatric symptomatology, particularly to the numbers of manic and depressive episodes, and to the polygenic load for comorbid conditions, including diabetes, hypertension and hypothyroidism.Taken together, our findings suggest that the effects of Li on symptomatology and comorbidity in BP are partially modulated by common genetic factors, with differential effects between BP-I and BP-II.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
700	1	a Adli, Mazda4 aut
700	1	a Akiyama, Kazufumi4 aut
700	1	a Akula, Nirmala4 aut
700	1	a Amare, Azmeraw T4 aut
700	1	a Ardau, Raffaella4 aut
700	1	a Arias, Bárbara4 aut
700	1	a Aubry, Jean-Michel4 aut
700	1	a Backlund, Lena4 aut
700	1	a Bellivier, Frank4 aut
700	1	a Benabarre, Antonio4 aut
700	1	a Bengesser, Susanne4 aut
700	1	a Bhattacharjee, Abesh Kumar4 aut
700	1	a Biernacka, Joanna M4 aut
700	1	a Birner, Armin4 aut
700	1	a Cearns, Micah4 aut
700	1	a Cervantes, Pablo4 aut
700	1	a Chen, Hsi-Chung4 aut
700	1	a Chillotti, Caterinau Karolinska Institutet4 aut
700	1	a Cichon, Sven4 aut
700	1	a Clark, Scott R4 aut
700	1	a Colom, Francesc4 aut
700	1	a Cruceanu, Cristiana4 aut
700	1	a Czerski, Piotr M4 aut
700	1	a Dalkner, Nina4 aut
700	1	a Degenhardt, Franziska4 aut
700	1	a Del Zompo, Maria4 aut
700	1	a DePaulo, J Raymond4 aut
700	1	a Etain, Bruno4 aut
700	1	a Falkai, Peter4 aut
700	1	a Ferensztajn-Rochowiak, Ewa4 aut
700	1	a Forstner, Andreas J4 aut
700	1	a Frank, Josef4 aut
700	1	a Frisén, Louiseu Karolinska Institutet4 aut
700	1	a Frye, Mark A4 aut
700	1	a Fullerton, Janice M4 aut
700	1	a Gallo, Carla4 aut
700	1	a Gard, Sébastien4 aut
700	1	a Garnham, Julie S4 aut
700	1	a Goes, Fernando S4 aut
700	1	a Grigoroiu-Serbanescu, Maria4 aut
700	1	a Grof, Paul4 aut
700	1	a Hashimoto, Ryota4 aut
700	1	a Hasler, Roland4 aut
700	1	a Hauser, Joanna4 aut
700	1	a Heilbronner, Urs4 aut
700	1	a Herms, Stefan4 aut
700	1	a Hoffmann, Per4 aut
700	1	a Hou, Liping4 aut
700	1	a Hsu, Yi-Hsiang4 aut
700	1	a Jamain, Stéphane4 aut
700	1	a Jiménez, Esther4 aut
700	1	a Kahn, Jean-Pierre4 aut
700	1	a Kassem, Layla4 aut
700	1	a Kato, Tadafumi4 aut
700	1	a Kelsoe, John4 aut
700	1	a Kittel-Schneider, Sarah4 aut
700	1	a Kuo, Po-Hsiu4 aut
700	1	a Kusumi, Ichiro4 aut
700	1	a König, Barbara4 aut
700	1	a Laje, Gonzalo4 aut
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
700	1	a Lavebratt, Catharina4 aut
700	1	a Leboyer, Marion4 aut
700	1	a Leckband, Susan G4 aut
700	1	a Maj, Mariou Karolinska Institutet4 aut
700	1	a Manchia, Mirko4 aut
700	1	a Marie-Claire, Cynthia4 aut
700	1	a Martinsson, Linau Karolinska Institutet4 aut
700	1	a McCarthy, Michael J4 aut
700	1	a McElroy, Susan L4 aut
700	1	a Millischer, Vincentu Karolinska Institutet4 aut
700	1	a Mitjans, Marina4 aut
700	1	a Mondimore, Francis M4 aut
700	1	a Monteleone, Palmiero4 aut
700	1	a Nievergelt, Caroline M4 aut
700	1	a Novák, Tomas4 aut
700	1	a Nöthen, Markus M4 aut
700	1	a O'Donovan, Claire4 aut
700	1	a Ozaki, Norio4 aut
700	1	a Papiol, Sergi4 aut
700	1	a Pfennig, Andrea4 aut
700	1	a Pisanu, Claudia4 aut
700	1	a Potash, James B4 aut
700	1	a Reif, Andreas4 aut
700	1	a Reininghaus, Eva4 aut
700	1	a Richard-Lepouriel, Hélène4 aut
700	1	a Roberts, Gloria4 aut
700	1	a Rouleau, Guy A4 aut
700	1	a Rybakowski, Janusz K4 aut
700	1	a Schalling, Martin4 aut
700	1	a Schofield, Peter R4 aut
700	1	a Schubert, Klaus Oliver4 aut
700	1	a Schulte, Eva C4 aut
700	1	a Schweizer, Barbara W4 aut
700	1	a Severino, Giovanni4 aut
700	1	a Shekhtman, Tatyana4 aut
700	1	a Shilling, Paul D4 aut
700	1	a Shimoda, Katzutaka4 aut
700	1	a Simhandl, Christian4 aut
700	1	a Slaney, Claire M4 aut
700	1	a Squassina, Alessio4 aut
700	1	a Stamm, Thomas4 aut
700	1	a Stopkova, Pavla4 aut
700	1	a Streit, Fabian4 aut
700	1	a Tekola-Ayele, Fasil4 aut
700	1	a Thalamuthu, Anbupalam4 aut
700	1	a Tortorella, Alfonso4 aut
700	1	a Turecki, Gustavo4 aut
700	1	a Veeh, Julia4 aut
700	1	a Vieta, Eduard4 aut
700	1	a Viswanath, Biju4 aut
700	1	a Witt, Stephanie H4 aut
700	1	a Zandi, Peter P4 aut
700	1	a Alda, Martin4 aut
700	1	a Bauer, Michael4 aut
700	1	a McMahon, Francis J4 aut
700	1	a Mitchell, Philip B4 aut
700	1	a Rietschel, Marcella4 aut
700	1	a Schulze, Thomas G4 aut
700	1	a Baune, Bernhard T4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t Research square
856	4 8	u https://gup.ub.gu.se/publication/333382
856	4 8	u https://doi.org/10.21203/rs.3.rs-3677630/v1
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:238077040

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