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WFRF:(Filho Miguel Inacio da Silva)
 

Sökning: WFRF:(Filho Miguel Inacio da Silva) > Bortezomib-induced ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003923naa a2200445 4500
001oai:lup.lub.lu.se:e3a6a058-272e-43bb-925d-bf5b3d890551
003SwePub
008170419s2018 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/e3a6a058-272e-43bb-925d-bf5b3d8905512 URI
0247 a https://doi.org/10.1002/hon.23912 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Campo, Chiarau German Cancer Research Centre4 aut
2451 0a Bortezomib-induced peripheral neuropathy : A genome-wide association study on multiple myeloma patients
264 c 2017-03-20
264 1b Wiley,c 2018
520 a The proteasome-inhibitor bortezomib was introduced into the treatment of multiple myeloma more than a decade ago. It is clinically beneficial, but peripheral neuropathy (PNP) is a side effect that may limit its use in some patients. To examine the possible genetic predisposing factors to PNP, we performed a genome-wide association study on 646 bortezomib-treated German multiple myeloma patients. Our aim was to identify genetic risk variants associated with the development of PNP as a serious side effect of the treatment. We identified 4 new promising loci for bortezomib-induced PNP at 4q34.3 (rs6552496), 5q14.1 (rs12521798), 16q23.3 (rs8060632), and 18q21.2 (rs17748074). Even though the results did not reach genome-wide significance level, they support the idea of previous studies, suggesting a genetic basis for neurotoxicity. The identified single nucleotide polymorphisms map to genes or next to genes involved in the development and function of the nervous system (CDH13, DCC, and TENM3). As possible functional clues, 2 of the variants, rs12521798 and rs17748074, affect enhancer histone marks in the brain. The rs12521798 may also impact expression of THBS4, which affects specific signal trasduction pathways in the nervous system. Further research is needed to clarify the mechanism of action of the identified single nucleotide polymorphisms in the development of drug-induced PNP and to functionally validate our in silico predictions.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a Bortezomib
653 a Genetic variants
653 a GWAS
653 a Multiple myeloma
653 a Neuropathy
653 a SNPs
7001 a da Silva Filho, Miguel Inaciou German Cancer Research Centre4 aut0 (Swepub:lu)med-md_
7001 a Weinhold, Nielsu University of Arkansas for Medical Sciences4 aut
7001 a Mahmoudpour, Seyed Hamidrezau German Cancer Research Centre4 aut0 (Swepub:lu)se8521ha
7001 a Goldschmidt, Hartmutu Heidelberg University4 aut
7001 a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre4 aut0 (Swepub:lu)med-khk
7001 a Merz, Maximilianu German Cancer Research Centre4 aut
7001 a Försti, Astau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre4 aut0 (Swepub:lu)med-asf
7102 a German Cancer Research Centreb University of Arkansas for Medical Sciences4 org
7730 t Hematological Oncologyd : Wileyg 36:1, s. 232-237q 36:1<232-237x 0278-0232
8564 u http://dx.doi.org/10.1002/hon.2391y FULLTEXT
8564 8u https://lup.lub.lu.se/record/e3a6a058-272e-43bb-925d-bf5b3d890551
8564 8u https://doi.org/10.1002/hon.2391

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