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Clinical utility of...
Clinical utility of risk modelsto refer patients with adnexal masses to specialized oncology care : Multicenter external validation using decision curve analysis
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- Wynants, Laure (author)
- Catholic University of Leuven
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- Timmerman, Dirk (author)
- Catholic University of Leuven
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- Verbakel, Jan Y. (author)
- Catholic University of Leuven,University of Oxford
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- Testa, Antonia (author)
- Catholic University of the Sacred Heart, Rome
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- Savelli, Luca (author)
- St. Orsola-Malpighi University Hospital
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- Fischerova, Daniela (author)
- General University Hospital in Prague
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- Franchi, Dorella (author)
- European Institute of Oncology
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- Van Holsbeke, Caroline (author)
- Hospital Oost-Limburg
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- Epstein, Elisabeth (author)
- Karolinska Institutet,Karolinska University Hospital
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- Froyman, Wouter (author)
- University Hospitals Leuven,Catholic University of Leuven
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- Guerriero, Stefano (author)
- Azienda Ospedaliero Universitaria-Policlinico Duilio Casula
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- Rossi, Alberto (author)
- University of Udine
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- Fruscio, Robert (author)
- European Institute of Oncology
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- Leone, Francesco P.G. (author)
- Luigi Sacco University Hospital
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- Bourne, Tom (author)
- University Hospitals Leuven,Catholic University of Leuven,Queen Charlotte's and Chelsea Hospital
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- Valentin, Lil (author)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital
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- Van Calster, Ben (author)
- Catholic University of Leuven
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(creator_code:org_t)
- 2017
- 2017
- English 9 s.
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In: Clinical Cancer Research. - 1078-0432. ; 23:17, s. 5082-5090
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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Abstract
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- Purpose: To evaluate the utility of preoperative diagnostic models for ovarian cancer based on ultrasound and/or biomarkers for referring patients to specialized oncology care. The investigated models were RMI, ROMA, and 3 models from the International Ovarian Tumor Analysis (IOTA) group [LR2, ADNEX, and the Simple Rules risk score (SRRisk)]. Experimental Design: A secondary analysis of prospectively collected data from 2 cross-sectional cohort studies was performed to externally validate diagnostic models. A total of 2, 763 patients (2, 403 in dataset 1 and 360 in dataset 2) from 18 centers (11 oncology centers and 7 nononcology hospitals) in 6 countries participated. Excised tissue was histologically classified as benign or malignant. The clinical utility of the preoperative diagnostic models was assessed with net benefit (NB) at a range of risk thresholds (5%-50% risk of malignancy) to refer patients to specialized oncology care. We visualized results with decision curves and generated bootstrap confidence intervals. Results: The prevalence of malignancy was 41% in dataset 1 and 40% in dataset 2. For thresholds up to 10% to 15%, RMI and ROMA had a lower NB than referring all patients. SRRisks and ADNEX demonstrated the highest NB. At a threshold of 20%, the NBs of ADNEX, SRrisks, and RMI were 0.348, 0.350, and 0.270, respectively. Results by menopausal status and type of center (oncology vs. nononcology) were similar. Conclusions: All tested IOTA methods, especially ADNEX and SRRisks, are clinically more useful than RMI and ROMA to select patients with adnexal masses for specialized oncology care.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- risk models
- Adnexal Masses
- oncology care
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Wynants, Laure
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Timmerman, Dirk
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Verbakel, Jan Y.
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Testa, Antonia
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Savelli, Luca
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Fischerova, Dani ...
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show more...
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Franchi, Dorella
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Van Holsbeke, Ca ...
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Epstein, Elisabe ...
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Froyman, Wouter
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Guerriero, Stefa ...
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Rossi, Alberto
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Fruscio, Robert
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Leone, Francesco ...
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Bourne, Tom
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Valentin, Lil
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Van Calster, Ben
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
- Articles in the publication
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Clinical Cancer ...
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Clinical cancer ...
- By the university
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Lund University
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Karolinska Institutet