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The human gut micro...
The human gut microbiome in early-onset type 1 diabetes from the TEDDY study
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- Vatanen, Tommi (författare)
- Broad Institute
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- Franzosa, Eric A. (författare)
- Harvard University,Broad Institute
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- Schwager, Randall (författare)
- Harvard University
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visa fler...
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- Tripathi, Surya (författare)
- Broad Institute
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- Arthur, Timothy D. (författare)
- Broad Institute
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- Vehik, Kendra (författare)
- University of South Florida
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Hagopian, William A. (författare)
- Pacific Northwest Research Institute
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- Rewers, Marian J. (författare)
- University of Colorado
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- She, Jin Xiong (författare)
- Medical College of Georgia
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- Toppari, Jorma (författare)
- University of Turku,Turku University Hospital
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- Ziegler, Anette G. (författare)
- Technical University of Munich,Klinikum rechts der Isar,Helmholtz Zentrum München
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- Akolkar, Beena (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Krischer, Jeffrey P. (författare)
- University of South Florida
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- Stewart, Christopher J. (författare)
- Baylor College of Medicine,University of Newcastle upon Tyne
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- Ajami, Nadim J. (författare)
- Baylor College of Medicine
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- Petrosino, Joseph F. (författare)
- Baylor College of Medicine
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- Gevers, Dirk (författare)
- Broad Institute,Janssen Pharmaceuticals, US
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- Lähdesmäki, Harri (författare)
- Aalto University
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- Vlamakis, Hera (författare)
- Broad Institute
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- Huttenhower, Curtis (författare)
- Harvard University,Broad Institute
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- Xavier, Ramnik J. (författare)
- Massachusetts General Hospital,Massachusetts Institute of Technology,Harvard University,Broad Institute
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(creator_code:org_t)
- 2018-10-24
- 2018
- Engelska 6 s.
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 562:7728, s. 589-594
- Relaterad länk:
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http://dx.doi.org/10...
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Type 1 diabetes (T1D) is an autoimmune disease that targets pancreatic islet beta cells and incorporates genetic and environmental factors1, including complex genetic elements2, patient exposures3 and the gut microbiome4. Viral infections5 and broader gut dysbioses6 have been identified as potential causes or contributing factors; however, human studies have not yet identified microbial compositional or functional triggers that are predictive of islet autoimmunity or T1D. Here we analyse 10,913 metagenomes in stool samples from 783 mostly white, non-Hispanic children. The samples were collected monthly from three months of age until the clinical end point (islet autoimmunity or T1D) in the The Environmental Determinants of Diabetes in the Young (TEDDY) study, to characterize the natural history of the early gut microbiome in connection to islet autoimmunity, T1D diagnosis, and other common early life events such as antibiotic treatments and probiotics. The microbiomes of control children contained more genes that were related to fermentation and the biosynthesis of short-chain fatty acids, but these were not consistently associated with particular taxa across geographically diverse clinical centres, suggesting that microbial factors associated with T1D are taxonomically diffuse but functionally more coherent. When we investigated the broader establishment and development of the infant microbiome, both taxonomic and functional profiles were dynamic and highly individualized, and dominated in the first year of life by one of three largely exclusive Bifidobacterium species (B. bifidum, B. breve or B. longum) or by the phylum Proteobacteria. In particular, the strain-specific carriage of genes for the utilization of human milk oligosaccharide within a subset of B. longum was present specifically in breast-fed infants. These analyses of TEDDY gut metagenomes provide, to our knowledge, the largest and most detailed longitudinal functional profile of the developing gut microbiome in relation to islet autoimmunity, T1D and other early childhood events. Together with existing evidence from human cohorts7,8 and a T1D mouse model9, these data support the protective effects of short-chain fatty acids in early-onset human T1D.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Av författaren/redakt...
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Vatanen, Tommi
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Franzosa, Eric A ...
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Schwager, Randal ...
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Tripathi, Surya
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Arthur, Timothy ...
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Vehik, Kendra
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Lernmark, Åke
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Hagopian, Willia ...
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Rewers, Marian J ...
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She, Jin Xiong
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Toppari, Jorma
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Ziegler, Anette ...
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Akolkar, Beena
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Krischer, Jeffre ...
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Stewart, Christo ...
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Ajami, Nadim J.
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Petrosino, Josep ...
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Gevers, Dirk
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Lähdesmäki, Harr ...
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Vlamakis, Hera
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Huttenhower, Cur ...
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Xavier, Ramnik J ...
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