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A novel derivative ...
A novel derivative of the fungal antimicrobial peptide plectasin is active against Mycobacterium tuberculosis
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- Tenland, Erik (author)
- Lund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Sweden
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- Krishnan, Nitya (author)
- Imperial College London,Imperial Coll London, England
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- Rönnholm, Anna (author)
- Lund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Sweden
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- Kalsum, Sadaf (author)
- Linköpings universitet,Linköping University,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Puthia, Manoj (author)
- Lund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Lund Univ, Sweden
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- Mörgelin, Matthias (author)
- Karolinska Institutet,Cobsyx AB, Sweden
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- Davoudi, Mina (author)
- Lund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Lund Univ, Sweden
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- Otrocka, Magdalena (author)
- Karolinska Institute,Karolinska Inst, Sweden
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- Alaridah, Nader (author)
- Lund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Sweden
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- Glegola-Madejska, Izabela (author)
- Imperial College London,Imperial Coll London, England
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- Sturegård, Erik (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups,Lund Univ, Sweden
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- Schmidtchen, Artur (author)
- Lund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Lund Univ, Sweden
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- Lerm, Maria (author)
- Linköpings universitet,Linköping University,Avdelningen för mikrobiologi och molekylär medicin,Medicinska fakulteten
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- Robertson, Brian D. (author)
- Imperial College London,Imperial Coll London, England
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- Godaly, Gabriela (author)
- Lund University,Lunds universitet,Medicinsk mikrobiologi,Forskargrupper vid Lunds universitet,Medical Microbiology,Lund University Research Groups,Lund Univ, Sweden
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English 8 s.
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In: Tuberculosis. - : Elsevier BV. - 1472-9792 .- 1873-281X. ; 113, s. 231-238
- Related links:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Tuberculosis has been reaffirmed as the infectious disease causing most deaths in the world. Co-infection with HIV and the increase in multi-drug resistant Mycobacterium tuberculosis strains complicate treatment and increases mortality rates, making the development of new drugs an urgent priority. In this study we have identified a promising candidate by screening antimicrobial peptides for their capacity to inhibit mycobacterial growth. This non-toxic peptide, NZX, is capable of inhibiting both clinical strains of M. tuberculosis and an MDR strain at therapeutic concentrations. The therapeutic potential of NZX is further supported in vivo where NZX significantly lowered the bacterial load with only five days of treatment, comparable to rifampicin treatment over the same period. NZX possesses intracellular inhibitory capacity and co-localizes with intracellular bacteria in infected murine lungs. In conclusion, the data presented strongly supports the therapeutic potential of NZX in future anti-TB treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Antimicrobial peptides
- Mycobacterium tuberculosis
- Tuberculosis treatment
- Mycobacterium tuberculosis; Antimicrobial peptides; Tuberculosis treatment
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Tenland, Erik
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Krishnan, Nitya
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Rönnholm, Anna
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Kalsum, Sadaf
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Puthia, Manoj
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Mörgelin, Matthi ...
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show more...
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Davoudi, Mina
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Otrocka, Magdale ...
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Alaridah, Nader
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Glegola-Madejska ...
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Sturegård, Erik
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Schmidtchen, Art ...
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Lerm, Maria
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Robertson, Brian ...
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Godaly, Gabriela
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Tuberculosis
- By the university
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Lund University
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Karolinska Institutet
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Linköping University