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Breast-Feeding and ...
Breast-Feeding and Childhood-Onset Type 1 Diabetes A pooled analysis of individual participant data from 43 observational studies
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- Cardwell, Chris R (author)
- Queens University of Belfast, North Ireland
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- Stene, Lars C (author)
- Norwegian Institute Public Heatlh, Norway Oslo University Hospital, Norway
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- Ludvigsson, Johnny (author)
- Östergötlands Läns Landsting,Linköpings universitet,Pediatrik,Hälsouniversitetet,Barn- och ungdomskliniken i Linköping
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- Rosenbauer, Joachim (author)
- University of Dusseldorf, Germany
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- Cinek, Ondrej (author)
- Charles University of Prague, Czech Republic University Hospital Motol, Czech Republic
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- Svensson, Jannet (author)
- Herlev University Hospital, Denmark
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- Perez-Bravo, Francisco (author)
- University of Chile, Chile
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- Memon, Anjum (author)
- Brighton and Sussex Medical School and NHS Brighton and Hove, England
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- Gimeno, Suely G (author)
- University of Federal Sao Paulo, Brazil
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- Wadsworth, Emma J K (author)
- Cardiff University, Wales
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- Strotmeyer, Elsa S (author)
- University of Pittsburgh, PA USA
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- Goldacre, Michael J (author)
- University of Oxford, England
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- Radon, Katja (author)
- Hospital Ludwig Maximilian University of Munich, Germany
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- Chuang, Lee-Ming (author)
- National Taiwan University Hospital, Taiwan
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- Parslow, Roger C (author)
- University of Leeds, England
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- Chetwynd, Amanda (author)
- University of Lancaster, England
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- Karavanaki, Kyriaki (author)
- University of Athens, Greece
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- Brigis, Girts (author)
- Riga Stradins University, Latvia
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- Pozzilli, Paolo (author)
- University of Campus Biomed, Italy
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- Urbonaite, Brone (author)
- Lithuanian University of Health Science, Lithuania
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- Schober, Edith (author)
- Medical University of Vienna, Austria
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- Devoti, Gabriele (author)
- University of Salento, Italy
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- Sipetic, Sandra (author)
- University of Belgrade, Serbia
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- Joner, Geir (author)
- University of Oslo, Norway Oslo University Hospital, Norway
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- Ionescu-Tirgoviste, Constantin (author)
- N Paulescu Institute Diabet, Romania
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- de Beaufort, Carine E (author)
- Clin Pediat Luxembourg, Luxembourg
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- Harrild, Kirsten (author)
- University of Aberdeen, Scotland
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- Benson, Victoria (author)
- University of Oxford, England
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- Savilahti, Erkki (author)
- University of Helsinki, Finland
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- Ponsonby, Anne-Louise (author)
- Royal Childrens Hospital, Australia
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- Salem, Mona (author)
- Ain Shams University, Egypt
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- Rabiei, Samira (author)
- Shahid Beheshti University of Medical Science and Health Serv, Iran
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- C Patterson, Chris (author)
- Queens University of Belfast, North Ireland
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(creator_code:org_t)
- 2012-10-13
- 2012
- English.
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 35:11, s. 2215-2225
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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https://care.diabete...
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https://doi.org/10.2...
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Abstract
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- OBJECTIVE-To investigate if there is a reduced risk of type 1 diabetes in children breastfed or exclusively breastfed by performing a pooled analysis with adjustment for recognized confounders. less thanbrgreater than less thanbrgreater thanRESEARCH DESIGN AND METHODS-Relevant studies were identified from literature searches using MEDLINE, Web of Science, and EMBASE. Authors of relevant studies were asked to provide individual participant data or conduct prespecified analyses. Meta-analysis techniques were used to combine odds ratios (ORs) and investigate heterogeneity between studies. less thanbrgreater than less thanbrgreater thanRESULTS-Data were available from 43 studies including 9,874 patients with type 1 diabetes. Overall, there was a reduction in the risk of diabetes after exclusive breast-feeding for andgt;2 weeks (20 studies; OR = 0.75, 95% CI 0.64-0.88), the association after exclusive breast-feeding for andgt;3 months was weaker (30 studies; OR = 0.87, 95% CI 0.75-1.00), and no association was observed after (nonexclusive) breast-feeding for andgt;2 weeks (28 studies; OR = 0.93, 95% CI 0.81-1.07) or andgt;3 months (29 studies; OR = 0.88, 95% CI 0.78-1.00). These associations were all subject to marked heterogeneity (I-2 = 58, 76, 54, and 68%, respectively). In studies with lower risk of bias, the reduced risk after exclusive breast-feeding for andgt;2 weeks remained (12 studies; OR = 0.86, 95% CI 0.75-0.99), and heterogeneity was reduced (I-2 = 0%). Adjustments for potential confounders altered these estimates very little. less thanbrgreater than less thanbrgreater thanCONCLUSIONS-The pooled analysis suggests weak protective associations between exclusive breast-feeding and type 1 diabetes risk. However, these findings are difficult to interpret because of the marked variation in effect and possible biases (particularly recall bias) inherent in the included studies.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cardwell, Chris ...
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Stene, Lars C
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Ludvigsson, John ...
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Rosenbauer, Joac ...
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Cinek, Ondrej
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Svensson, Jannet
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Perez-Bravo, Fra ...
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Memon, Anjum
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Gimeno, Suely G
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Wadsworth, Emma ...
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Strotmeyer, Elsa ...
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Goldacre, Michae ...
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Radon, Katja
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Chuang, Lee-Ming
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Parslow, Roger C
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Chetwynd, Amanda
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Karavanaki, Kyri ...
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Brigis, Girts
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Pozzilli, Paolo
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Urbonaite, Brone
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Schober, Edith
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Devoti, Gabriele
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Sipetic, Sandra
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Joner, Geir
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Ionescu-Tirgovis ...
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de Beaufort, Car ...
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Harrild, Kirsten
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Benson, Victoria
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Savilahti, Erkki
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Ponsonby, Anne-L ...
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Salem, Mona
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Rabiei, Samira
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C Patterson, Chr ...
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- Articles in the publication
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Diabetes Care
- By the university
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Linköping University