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WFRF:(Hamzic Namik)
 

Sökning: WFRF:(Hamzic Namik) > Interleukin-6 produ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003230nam a2200337 4500
001oai:DiVA.org:liu-87452
003SwePub
008130118| | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-874522 URI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a ovr2 swepub-publicationtype
1001 a Hamzic, Namiku Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)namha08
2451 0a Interleukin-6 produced by non-hematopoietic cells mediates the lipopolysaccharide-induced febrile response
338 a print2 rdacarrier
520 a Interleukin-6 (IL-6) is critical for the lipopolysaccharide (LPS)-induced febrile response. However, the exact source(s) of IL-6 involved in regulating the LPS-elicited fever is still to be identified. One known source of IL-6 is hematopoietic cells, such as monocytes. To clarify the contribution of hematopoietically derived IL-6 to fever, we created chimeric mice expressing IL-6 either in cells of hematopoietic or, conversely, in cells of non-hematopoietic origin. This was performed by extinguishing hematopoetic cells in wild-type (WT) or IL-6 knockout (IL-6 KO) mice by whole-body irradiation and transplanting them with new stem cells. Mice lacking IL-6 in hematopoietic cells displayed normal fever to LPS and were found to have similar levels of IL-6 in the cerebrospinal fluid (CSF) and in plasma as well as similar expression of the IL-6 gene in the brain as WT mice. In contrast, IL-6 KO mice, with intact IL-6 production in cells of hematopoietic origin, only showed a minor elevation of the body temperature after peripheral LPS injection. While they displayed significantly elevated levels of IL-6 both in plasma and CSF compared with control mice, the increase was modest compared with that seen in LPS injected mice on WT background, the latter being approximately 20 times larger in magnitude. These results suggest that IL-6 of nonhematopoietic origin is the main source of IL-6 in LPS-induced fever, and that IL-6 produced by hematopoietic cells only plays a minor role.
653 a Interleukin-6
653 a hematopoietic cells
653 a bone marrow transplantation
653 a fever
7001 a Tang, Yanjuanu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)yanta19
7001 a Eskilsson, Annau Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)annes38
7001 a Kugelberg, Unnu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)unnor29
7001 a Ruud, Johanu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)johru61
7001 a Jönsson, Jan-Ingvaru Linköpings universitet,Experimentell patologi,Hälsouniversitetet4 aut0 (Swepub:liu)janjo86
7001 a Blomqvist, Andersu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)andbl47
7001 a Nilsberth, Camillau Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)camni68
7102 a Linköpings universitetb Cellbiologi4 org
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-87452

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