Sökning: WFRF:(Harbs Justin)
> (2022) >
Pre-diagnostic circ...
Pre-diagnostic circulating resistin concentrations are not associated with colorectal cancer risk in the european prospective investigation into cancer and nutrition study
-
- Pham, Thu-Thi (författare)
- Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
-
- Nimptsch, Katharina (författare)
- Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
-
- Aleksandrova, Krasimira (författare)
- Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany
-
visa fler...
-
- Jenab, Mazda (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), World Health Organization, 150 Cours Albert Thomas, Lyon, France
-
- Reichmann, Robin (författare)
- Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany
-
- Wu, Kana (författare)
- Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
-
- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
-
- Kyrø, Cecilie (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark
-
- Schulze, Matthias B. (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
-
- Kaaks, Rudolf (författare)
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
-
- Katzke, Verena (författare)
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
-
- Palli, Domenico (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
-
- Pasanisi, Fabrizio (författare)
- Dipartimento di Medicina Clinica E Chirurgia, Federico Ii University, Naples, Italy
-
- Ricceri, Fulvio (författare)
- Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy; Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco, Italy
-
- Tumino, Rosario (författare)
- Hyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy
-
- Krogh, Vittorio (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, Milan, Italy
-
- Roodhart, Jeanine (författare)
- Department of Medical Oncology, UMC Utrecht, Utrecht, Netherlands
-
- Castilla, Jesús (författare)
- Navarra Public Health Institute—IdiSNA, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
-
- Sánchez, Maria-Jose (författare)
- CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
-
- Colorado-Yohar, Sandra Milena (författare)
- CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
-
- Harbs, Justin (författare)
- Umeå universitet,Onkologi
-
- Rutegård, Martin, 1982- (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Kirurgi
-
- Papier, Keren (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
-
- Aglago, Elom K. (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
-
- Dimou, Niki (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), World Health Organization, 150 Cours Albert Thomas, Lyon, France
-
- Mayen-Chacon, Ana-Lucia (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), World Health Organization, 150 Cours Albert Thomas, Lyon, France
-
- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
-
- Pischon, Tobias (författare)
- Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany; Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Biobank Technology Platform, Berlin, Germany; Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Core Facility Biobank, Berlin, Germany
-
visa färre...
-
(creator_code:org_t)
- 2022-11-09
- 2022
- Engelska.
-
Ingår i: Cancers. - : MDPI. - 2072-6694. ; 14:22
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Resistin is a polypeptide implicated in inflammatory processes, and as such could be linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic resistin concentrations and CRC risk within the European Prospective Investigation into Cancer and Nutrition using a nested case-control study among 1293 incident CRC-diagnosed cases and 1293 incidence density-matched controls. Conditional logistic regression models controlled for matching factors (age, sex, study center, fasting status, and women-related factors in women) and potential confounders (education, dietary and lifestyle factors, body mass index (BMI), BMI-adjusted waist circumference residuals) were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for CRC. Higher circulating resistin concentrations were not associated with CRC (RR per doubling resistin, 1.11; 95% CI 0.94–1.30; p = 0.22). There were also no associations with CRC subgroups defined by tumor subsite or sex. However, resistin was marginally associated with a higher CRC risk among participants followed-up maximally two years, but not among those followed-up after more than two years. We observed no substantial correlation between baseline circulating resistin concentrations and adiposity measures (BMI, waist circumference), adipokines (adiponectin, leptin), or metabolic and inflammatory biomarkers (C-reactive protein, C-peptide, high-density lipoprotein cholesterol, reactive oxygen metabolites) among controls. In this large-scale prospective cohort, there was little evidence of an association between baseline circulating resistin concentrations and CRC risk in European men and women.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- colorectal cancer
- inflammation
- pre-diagnostic resistin
- prospective
- risk
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Cancers
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Pham, Thu-Thi
-
Nimptsch, Kathar ...
-
Aleksandrova, Kr ...
-
Jenab, Mazda
-
Reichmann, Robin
-
Wu, Kana
-
visa fler...
-
Tjønneland, Anne
-
Kyrø, Cecilie
-
Schulze, Matthia ...
-
Kaaks, Rudolf
-
Katzke, Verena
-
Palli, Domenico
-
Pasanisi, Fabriz ...
-
Ricceri, Fulvio
-
Tumino, Rosario
-
Krogh, Vittorio
-
Roodhart, Jeanin ...
-
Castilla, Jesús
-
Sánchez, Maria-J ...
-
Colorado-Yohar, ...
-
Harbs, Justin
-
Rutegård, Martin ...
-
Papier, Keren
-
Aglago, Elom K.
-
Dimou, Niki
-
Mayen-Chacon, An ...
-
Weiderpass, Elis ...
-
Pischon, Tobias
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Cancers
- Av lärosätet
-
Umeå universitet