WFRF:(Harkonen T)
Sökning: WFRF:(Harkonen T) > Coxsackievirus immu...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03991naa a2200445 4500 | |
| 001 | oai:DiVA.org:liu-46679 | |
| 003 | SwePub | |
| 008 | 091011s2003 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-466792 URI |
| 024 | 7 | a https://doi.org/10.1002/jmv.103392 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Davydova, B.u Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland4 aut |
| 245 | 1 0 | a Coxsackievirus immunization delays onset of diabetes in non-obese diabetic mice |
| 264 | c 2003-02-24 | |
| 264 | 1 | b Wiley,c 2003 |
| 338 | a print2 rdacarrier | |
| 520 | a Enteroviruses may be involved in the pathogenesis of Type 1 diabetes through different mechanisms including triggering of autoimmunity. The effect of immunization with coxsackievirus B4-E2 on diabetes incidence was studied in the non-obese diabetic mice, an animal model for human autoimmune insulin-dependent diabetes mellitus. The immunization delayed the onset of diabetes in the mice, and the effect was mediated at least partially by virus immunization-activated splenocytes as demonstrated by adoptive transfer experiments. Immunization resulted in a strong humoral immune response against the immunizing virus, formalin-inactivated coxsackievirus B4-E2. Cell-mediated immune responseto virus antigen was characterised by interferon gamma and interleukin 10 secretion. The immunization also resulted in increased antibody levels against several beta-cell autoantigens. By using epitope mapping we were able to show that in addition to reactivity with the known epitopes of viral proteins and tyrosine phosphatase A-2 or heat shock protein 60, responses to some other regions of autoantigens were enhanced. In preproinsulin, the response was restricted against an antigenic region earlier identified as DR4-dependent epitope. This reactivity can not be explained by homologous amino acid sequences and it is possible that enterovirus immunization might change the autoantigen specific TH1/TH2 balance in non-obese diabetic mice. In conclusion, our results suggest that coxsackievirus immunization increased humoral immune response to beta cell autoantigens and this was associated with a less destructive pathology for spontaneous diabetes in non-obese diabetic mice. © 2003 Wiley-Liss, Inc. | |
| 653 | a Antibodies | |
| 653 | a Beta-cell autoantigen | |
| 653 | a Coxsackievirus | |
| 653 | a Enterovirus | |
| 653 | a Immunization | |
| 653 | a Insulin-dependent diabetes mellitus | |
| 653 | a Non-obese diabetic mice | |
| 653 | a T-cell responses | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Harkonen, T.u Härkönen, T., Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland4 aut |
| 700 | 1 | a Kaialainen, S.u Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland4 aut |
| 700 | 1 | a Hovi, T.u Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland4 aut |
| 700 | 1 | a Vaarala, Outiu Linköpings universitet,Hälsouniversitetet,Pediatrik4 aut0 (Swepub:liu)outva41 |
| 700 | 1 | a Roivainen, M.u Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland4 aut |
| 710 | 2 | a Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finlandb Härkönen, T., Enterovirus Laboratory, Natl. Public Health Institute (KTL), Mannerheimintie 166, FIN-00300 Helsinki, Finland4 org |
| 773 | 0 | t Journal of Medical Virologyd : Wileyg 69:4, s. 510-520q 69:4<510-520x 0146-6615x 1096-9071 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-46679 |
| 856 | 4 8 | u https://doi.org/10.1002/jmv.10339 |
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- Davydova, B.
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