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Sökning: WFRF:(Hellman Mats) > (2020-2024) > Immunological bioma...

Immunological biomarkers in patients with radiographic axial spondyloarthritis, an exploratory longitudinal Swedish study

Hellman, Urban, 1966- (författare)
Umeå universitet,Reumatologi,Immunologi/immunkemi
Lejon, Kristina, 1967- (författare)
Umeå universitet,Immunologi/immunkemi
Do, Lan (författare)
Umeå universitet,Reumatologi
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Geijer, Mats (författare)
Baraliakos, Xenofon (författare)
Witte, Torsten (författare)
Forsblad-d'Elia, Helena (författare)
Gothenburg University,Göteborgs universitet,Umeå universitet,Reumatologi,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research
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 (creator_code:org_t)
2024
2024
Engelska.
Ingår i: Modern Rheumatology. - : Oxford University Press. - 1439-7595 .- 1439-7609.
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
https://gup.ub.gu.se...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objectives: There is a need for more specific biomarkers to diagnose and predict disease course in patients with axial spondyloarthritis (axSpA). This study aimed to study immunological plasma biomarkers at different time-points in radiographic (r)-axSpA patients overall and stratified by sex and compare these biomarker patterns in r-axSpA patients concerning disease phenotypes and disease activity.Methods: Plasma samples were analysed from r-axSpA patients at and prior (Pre-Backbone) inclusion in the Backbone study. Interferon gamma, interleukin-10, -17A, -17F, -22, -23, -6, MCP-1, TNF-alpha, VEGF-A, MIF, IgA anti-CD74, zonulin, ESR, hsCRP, white blood cell count, and blood lipids were measured.Results: Biomarker pattern discriminated significantly between r-axSpA patients in Backbone and Pre-Backbone compared with controls. When stratifying by sex, it was possible to discriminate between male and female r-axSpA patients in Backbone vs controls and between male r-axSpA patients in pre-Backbone and controls. In Backbone, markers with high discriminative capacity were MIF, IgA anti-CD74, and MCP-1. In Pre-Backbone, IL-6, TNF-alpha, MIF, triglycerides, cholesterol, IL-10, and zonulin displayed high discriminative capacity.Conclusion: Based on their temporal pattern and mutual relationship, we suggest studying MIF, IgA anti-CD74, and MCP-1 in depth, at more time points, to further elucidate disease-driving mechanisms in this complex disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Nyckelord

Ankylosing spondylitis
biomarkers
longitudinal observational study
Northern Sweden Health and Disease Study
radiographic axial spondyloarthritis

Publikations- och innehållstyp

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