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Association of Rena...
Association of Renal Biochemical Parameters with Left Ventricular Diastolic Dysfunction in a Community-Based Elderly Population in China: A Cross-Sectional Study
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Zhou, J. M. (författare)
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Cui, X. T. (författare)
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Jin, X. J. (författare)
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Zhou, J. (författare)
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Zhang, H. Y. (författare)
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Tang, B. X. (författare)
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- Fu, Michael, 1963 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Herlitz, Hans, 1946 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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Cui, J. (författare)
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Zhu, H. M. (författare)
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Sun, A. J. (författare)
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Hu, K. (författare)
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Ge, J. B. (författare)
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(creator_code:org_t)
- 2014-02-12
- 2014
- Engelska.
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 9:2
- Relaterad länk:
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https://journals.plo...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Relationship of left ventricular diastolic dysfunction (LVDD) with parameters that could provide more information than hemodynamic renal indexes has not been clarified. We aimed to explore the association of comprehensive renal parameters with LVDD in a community-based elderly population. Methods: 1,166 community residents (aged >= 65 years, 694 females) participating in the Shanghai Heart Health Study with complete data of renal parameters were investigated. Echocardiography was used to evaluate diastolic function with conventional and tissue Doppler imaging techniques. Serum urea, creatinine, urea-to-creatinine ratio, estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (UACR) were analyzed on their associations with LVDD. Results: The prevalence of LVDD increased in proportion to increasing serum urea, urea-to-creatinine ratio and UACR. These three renal parameters were found negatively correlated to peak early (E) to late (A) diastolic velocities ratio (E/A), and positively to left atrial volume index; UACR also positively correlated with E to peak early (E') diastolic mitral annular velocity ratio (E/E'). Serum urea, urea-to-creatinine ratio and UACR correlated with LVDD in logistic univariate regression analysis, and urea-to-creatinine ratio remained independently correlated to LVDD [ Odds ratio (OR) 2.82, 95% confidence interval (CI) 1.34-5.95] after adjustment. Serum urea (OR 1.18, 95%CI 1.03-1.34), creatinine (OR 6.53, 95%CI 1.70-25.02), eGFR (OR 0.22, 95%CI 0.07-0.65) and UACR (OR 2.15, 95%CI 1.42-3.24) were revealed independent correlates of advanced (moderate and severe) LVDD. Conclusions: Biochemical parameters of renal function were closely linked with LVDD. This finding described new cardiorenal relationship in the elderly population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- URINARY ALBUMIN EXCRETION
- CHRONIC KIDNEY-DISEASE
- CHRONIC
- HEART-FAILURE
- BLOOD UREA NITROGEN
- GLOMERULAR-FILTRATION-RATE
- BRAIN
- NATRIURETIC PEPTIDE
- ENDOTHELIAL DYSFUNCTION
- CARDIOVASCULAR-DISEASE
- EJECTION FRACTION
- EUROPEAN SOCIETY
Publikations- och innehållstyp
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Plos One
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Till lärosätets databas
- Av författaren/redakt...
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Zhou, J. M.
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Cui, X. T.
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Jin, X. J.
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Zhou, J.
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Zhang, H. Y.
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Tang, B. X.
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Fu, Michael, 196 ...
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Herlitz, Hans, 1 ...
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Cui, J.
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Zhu, H. M.
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Sun, A. J.
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Hu, K.
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Ge, J. B.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Plos One
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Göteborgs universitet