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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 14976naa a2203841 4500 | |
| 001 | oai:DiVA.org:umu-166416 | |
| 003 | SwePub | |
| 008 | 191216s2019 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:142200157 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1664162 URI |
| 024 | 7 | a https://doi.org/10.1093/hmg/ddz0702 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1422001572 URI |
| 040 | a (SwePub)umud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Sung, Yun Ju4 aut |
| 245 | 1 0 | a A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure |
| 264 | c 2019-04-10 | |
| 264 | 1 | b Oxford University Press,c 2019 |
| 338 | a print2 rdacarrier | |
| 520 | a Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of these, 61 were previously published through main-effect analysis of BP traits, 37 were recently reported by us for systolic BP and/or diastolic BP through gene–smoking interaction analysis and 38 were newly identified (P < 5 × 10−8, false discovery rate < 0.05). We also identified nine new signals near known loci. Of the 136 loci, 8 showed significant interaction with smoking status. They include CSMD1 previously reported for insulin resistance and BP in the spontaneously hypertensive rats. Many of the 38 new loci show biologic plausibility for a role in BP regulation. SLC26A7 encodes a chloride/bicarbonate exchanger expressed in the renal outer medullary collecting duct. AVPR1A is widely expressed, including in vascular smooth muscle cells, kidney, myocardium and brain. FHAD1 is a long non-coding RNA overexpressed in heart failure. TMEM51 was associated with contractile function in cardiomyocytes. CASP9 plays a central role in cardiomyocyte apoptosis. Identified only in African ancestry were 30 novel loci. Our findings highlight the value of multi-ancestry investigations, particularly in studies of interaction with lifestyle factors, where genomic and lifestyle differences may contribute to novel findings. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a smoking | |
| 653 | a hypertension | |
| 653 | a genes | |
| 653 | a genome | |
| 653 | a life style | |
| 653 | a genetics | |
| 653 | a kidney | |
| 653 | a mean arterial pressure | |
| 653 | a blood pressure regulation | |
| 653 | a pulse pressure | |
| 653 | a genome-wide association study | |
| 700 | 1 | a de Las Fuentes, Lisa4 aut |
| 700 | 1 | a Winkler, Thomas W.4 aut |
| 700 | 1 | a Chasman, Daniel, I4 aut |
| 700 | 1 | a Bentley, Amy R.4 aut |
| 700 | 1 | a Kraja, Aldi T.4 aut |
| 700 | 1 | a Ntalla, Ioanna4 aut |
| 700 | 1 | a Warren, Helen R.4 aut |
| 700 | 1 | a Guo, Xiuqing4 aut |
| 700 | 1 | a Schwander, Karen4 aut |
| 700 | 1 | a Manning, Alisa K.4 aut |
| 700 | 1 | a Brown, Michael R.4 aut |
| 700 | 1 | a Aschard, Hugues4 aut |
| 700 | 1 | a Feitosa, Mary F.4 aut |
| 700 | 1 | a Franceschini, Nora4 aut |
| 700 | 1 | a Lu, Yingchang4 aut |
| 700 | 1 | a Cheng, Ching-Yu4 aut |
| 700 | 1 | a Sim, Xueling4 aut |
| 700 | 1 | a Vojinovic, Dina4 aut |
| 700 | 1 | a Marten, Jonathan4 aut |
| 700 | 1 | a Musani, Solomon K.4 aut |
| 700 | 1 | a Kilpelainen, Tuomas O.4 aut |
| 700 | 1 | a Richard, Melissa A.4 aut |
| 700 | 1 | a Aslibekyan, Stella4 aut |
| 700 | 1 | a Bartz, Traci M.4 aut |
| 700 | 1 | a Dorajoo, Rajkumar4 aut |
| 700 | 1 | a Li, Changwei4 aut |
| 700 | 1 | a Liu, Yongmei4 aut |
| 700 | 1 | a Rankinen, Tuomo4 aut |
| 700 | 1 | a Smith, Albert Vernon4 aut |
| 700 | 1 | a Tajuddin, Salman M.4 aut |
| 700 | 1 | a Tayo, Bamidele O.4 aut |
| 700 | 1 | a Zhao, Wei4 aut |
| 700 | 1 | a Zhou, Yanhua4 aut |
| 700 | 1 | a Matoba, Nana4 aut |
| 700 | 1 | a Sofer, Tamar4 aut |
| 700 | 1 | a Alver, Maris4 aut |
| 700 | 1 | a Amini, Marzyeh4 aut |
| 700 | 1 | a Boissel, Mathilde4 aut |
| 700 | 1 | a Chai, Jin Fang4 aut |
| 700 | 1 | a Chen, Xu4 aut |
| 700 | 1 | a Divers, Jasmin4 aut |
| 700 | 1 | a Gandin, Ilaria4 aut |
| 700 | 1 | a Gao, Chuan4 aut |
| 700 | 1 | a Giulianini, Franco4 aut |
| 700 | 1 | a Goel, Anuj4 aut |
| 700 | 1 | a Harris, Sarah E.4 aut |
| 700 | 1 | a Hartwig, Fernando P.4 aut |
| 700 | 1 | a He, Meian4 aut |
| 700 | 1 | a Horimoto, Andrea R. V. R.4 aut |
| 700 | 1 | a Hsu, Fang-Chi4 aut |
| 700 | 1 | a Jackson, Anne U.4 aut |
| 700 | 1 | a Kammerer, Candace M.4 aut |
| 700 | 1 | a Kasturiratne, Anuradhani4 aut |
| 700 | 1 | a Komulainen, Pirjou Karolinska Institutet4 aut |
| 700 | 1 | a Kuehnel, Brigitte4 aut |
| 700 | 1 | a Leander, Karinu Karolinska Institutet4 aut |
| 700 | 1 | a Lee, Wen-Jane4 aut |
| 700 | 1 | a Lin, Keng-Hung4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Lyytikainen, Leo-Pekka4 aut |
| 700 | 1 | a McKenzie, Colin A.4 aut |
| 700 | 1 | a Nelson, Christopher P.4 aut |
| 700 | 1 | a Noordam, Raymond4 aut |
| 700 | 1 | a Scott, Robert A.4 aut |
| 700 | 1 | a Sheu, Wayne H. H.4 aut |
| 700 | 1 | a Stancakova, Alena4 aut |
| 700 | 1 | a Takeuchi, Fumihiko4 aut |
| 700 | 1 | a van Der Most, Peter J.4 aut |
| 700 | 1 | a Varga, Tibor V.4 aut |
| 700 | 1 | a Waken, Robert J.4 aut |
| 700 | 1 | a Wang, Heming4 aut |
| 700 | 1 | a Wang, Yajuan4 aut |
| 700 | 1 | a Ware, Erin B.4 aut |
| 700 | 1 | a Weiss, Stefan4 aut |
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| 700 | 1 | a Yanek, Lisa R.4 aut |
| 700 | 1 | a Zhang, Weihua4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Afaq, Saima4 aut |
| 700 | 1 | a Alfred, Tamuno4 aut |
| 700 | 1 | a Amin, Najaf4 aut |
| 700 | 1 | a Arking, Dan E.4 aut |
| 700 | 1 | a Aung, Tin4 aut |
| 700 | 1 | a Barr, R. Graham4 aut |
| 700 | 1 | a Bielak, Lawrence F.4 aut |
| 700 | 1 | a Boerwinkle, Eric4 aut |
| 700 | 1 | a Bottinger, Erwin P.4 aut |
| 700 | 1 | a Braund, Peter S.4 aut |
| 700 | 1 | a Brody, Jennifer A.4 aut |
| 700 | 1 | a Broeckel, Ulrich4 aut |
| 700 | 1 | a Cade, Brian4 aut |
| 700 | 1 | a Campbell, Archie4 aut |
| 700 | 1 | a Canouil, Mickael4 aut |
| 700 | 1 | a Chakravarti, Aravinda4 aut |
| 700 | 1 | a Cocca, Massimiliano4 aut |
| 700 | 1 | a Collins, Francis S.4 aut |
| 700 | 1 | a Connell, John M.4 aut |
| 700 | 1 | a de Mutsert, Renee4 aut |
| 700 | 1 | a de Silva, H. Janaka4 aut |
| 700 | 1 | a Doerr, Marcus4 aut |
| 700 | 1 | a Duan, Qing4 aut |
| 700 | 1 | a Eaton, Charles B.4 aut |
| 700 | 1 | a Ehret, Georg4 aut |
| 700 | 1 | a Evangelou, Evangelos4 aut |
| 700 | 1 | a Faul, Jessica D.4 aut |
| 700 | 1 | a Forouhi, Nita G.4 aut |
| 700 | 1 | a Franco, Oscar H.4 aut |
| 700 | 1 | a Friedlander, Yechiel4 aut |
| 700 | 1 | a Gao, He4 aut |
| 700 | 1 | a Gigante, Brunau Karolinska Institutet4 aut |
| 700 | 1 | a Gu, C. Charles4 aut |
| 700 | 1 | a Gupta, Preeti4 aut |
| 700 | 1 | a Hagenaars, Saskia P.4 aut |
| 700 | 1 | a Harris, Tamara B.4 aut |
| 700 | 1 | a He, Jiang4 aut |
| 700 | 1 | a Heikkinen, Sami4 aut |
| 700 | 1 | a Heng, Chew-Kiat4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Howard, Barbara, V4 aut |
| 700 | 1 | a Hunt, Steven C.4 aut |
| 700 | 1 | a Irvin, Marguerite R.4 aut |
| 700 | 1 | a Jia, Yucheng4 aut |
| 700 | 1 | a Katsuya, Tomohiro4 aut |
| 700 | 1 | a Kaufman, Joel4 aut |
| 700 | 1 | a Kerrison, Nicola D.4 aut |
| 700 | 1 | a Khor, Chiea Chuen4 aut |
| 700 | 1 | a Koh, Woon-Puay4 aut |
| 700 | 1 | a Koistinen, Heikki A.4 aut |
| 700 | 1 | a Kooperberg, Charles B.4 aut |
| 700 | 1 | a Krieger, Jose E.4 aut |
| 700 | 1 | a Kubo, Michiaki4 aut |
| 700 | 1 | a Kutalik, Zoltan4 aut |
| 700 | 1 | a Kuusisto, Johanna4 aut |
| 700 | 1 | a Lakka, Timo A.4 aut |
| 700 | 1 | a Langefeld, Carl D.4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Launer, Lenore J.4 aut |
| 700 | 1 | a Lee, Joseph H.4 aut |
| 700 | 1 | a Lehne, Benjamin4 aut |
| 700 | 1 | a Levy, Daniel4 aut |
| 700 | 1 | a Lewis, Cora E.4 aut |
| 700 | 1 | a Li, Yize4 aut |
| 700 | 1 | a Lim, Sing Hui4 aut |
| 700 | 1 | a Liu, Ching-Ti4 aut |
| 700 | 1 | a Liu, Jianjun4 aut |
| 700 | 1 | a Liu, Jingmin4 aut |
| 700 | 1 | a Liu, Yeheng4 aut |
| 700 | 1 | a Loh, Marie4 aut |
| 700 | 1 | a Lohman, Kurt K.4 aut |
| 700 | 1 | a Louie, Tin4 aut |
| 700 | 1 | a Magi, Reedik4 aut |
| 700 | 1 | a Matsuda, Koichi4 aut |
| 700 | 1 | a Meitinger, Thomas4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Milani, Lili4 aut |
| 700 | 1 | a Momozawa, Yukihide4 aut |
| 700 | 1 | a Mosley, Thomas H., Jr.4 aut |
| 700 | 1 | a Nalls, Mike A.4 aut |
| 700 | 1 | a Nasri, Ubaydah4 aut |
| 700 | 1 | a O'Connell, Jeff R.4 aut |
| 700 | 1 | a Ogunniyi, Adesola4 aut |
| 700 | 1 | a Palmas, Walter R.4 aut |
| 700 | 1 | a Palmer, Nicholette D.4 aut |
| 700 | 1 | a Pankow, James S.4 aut |
| 700 | 1 | a Pedersen, Nancy L.u Karolinska Institutet4 aut |
| 700 | 1 | a Peters, Annette4 aut |
| 700 | 1 | a Peyser, Patricia A.4 aut |
| 700 | 1 | a Polasek, Ozren4 aut |
| 700 | 1 | a Porteous, David4 aut |
| 700 | 1 | a Raitakari, Olli T.4 aut |
| 700 | 1 | a Renström, Fridau Umeå universitet,Enheten för biobanksforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden4 aut0 (Swepub:umu)frre0001 |
| 700 | 1 | a Rice, Treva K.4 aut |
| 700 | 1 | a Ridker, Paul M.4 aut |
| 700 | 1 | a Robino, Antonietta4 aut |
| 700 | 1 | a Robinson, Jennifer G.4 aut |
| 700 | 1 | a Rose, Lynda M.4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Sabanayagam, Charumathi4 aut |
| 700 | 1 | a Salako, Babatunde L.4 aut |
| 700 | 1 | a Sandow, Kevin4 aut |
| 700 | 1 | a Schmidt, Carsten O.4 aut |
| 700 | 1 | a Schreiner, Pamela J.4 aut |
| 700 | 1 | a Scott, William R.4 aut |
| 700 | 1 | a Sever, Peter4 aut |
| 700 | 1 | a Sims, Mario4 aut |
| 700 | 1 | a Sitlani, Colleen M.4 aut |
| 700 | 1 | a Smith, Blair H.4 aut |
| 700 | 1 | a Smith, Jennifer A.4 aut |
| 700 | 1 | a Snieder, Harold4 aut |
| 700 | 1 | a Starr, John M.4 aut |
| 700 | 1 | a Strauch, Konstantin4 aut |
| 700 | 1 | a Tang, Hua4 aut |
| 700 | 1 | a Taylor, Kent D.4 aut |
| 700 | 1 | a Teo, Yik Ying4 aut |
| 700 | 1 | a Tham, Yih Chung4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a Waldenberger, Melanie4 aut |
| 700 | 1 | a Wang, Lihua4 aut |
| 700 | 1 | a Wang, Ya Xing4 aut |
| 700 | 1 | a Wei, Wen Bin4 aut |
| 700 | 1 | a Wilson, Gregory4 aut |
| 700 | 1 | a Wojczynski, Mary K.4 aut |
| 700 | 1 | a Xiang, Yong-Bing4 aut |
| 700 | 1 | a Yao, Jie4 aut |
| 700 | 1 | a Yu, Caizheng4 aut |
| 700 | 1 | a Yuan, Jian-Min4 aut |
| 700 | 1 | a Zonderman, Alan B.4 aut |
| 700 | 1 | a Becker, Diane M.4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Bowden, Donald W.4 aut |
| 700 | 1 | a Chambers, John C.4 aut |
| 700 | 1 | a Chen, Yii-Der Ida4 aut |
| 700 | 1 | a Weir, David R.4 aut |
| 700 | 1 | a de Faire, Ulfu Karolinska Institutet4 aut |
| 700 | 1 | a Deary, Ian J.4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Farrall, Martin4 aut |
| 700 | 1 | a Forrester, Terrence4 aut |
| 700 | 1 | a Freedman, Barry, I4 aut |
| 700 | 1 | a Froguel, Philippe4 aut |
| 700 | 1 | a Gasparini, Paolo4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Horta, Bernardo Lessa4 aut |
| 700 | 1 | a Hung, Yi-Jen4 aut |
| 700 | 1 | a Jonas, Jost Bruno4 aut |
| 700 | 1 | a Kato, Norihiro4 aut |
| 700 | 1 | a Kooner, Jaspal S.4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Lehtimaki, Terho4 aut |
| 700 | 1 | a Liang, Kae-Woei4 aut |
| 700 | 1 | a Magnusson, Patrik K. E.4 aut |
| 700 | 1 | a Oldehinkel, Albertine J.4 aut |
| 700 | 1 | a Pereira, Alexandre C.4 aut |
| 700 | 1 | a Perls, Thomas4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
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| 700 | 1 | a Rettig, Rainer4 aut |
| 700 | 1 | a Samani, Nilesh J.4 aut |
| 700 | 1 | a Scott, James4 aut |
| 700 | 1 | a Shu, Xiao-Ou4 aut |
| 700 | 1 | a van Der Harst, Pim4 aut |
| 700 | 1 | a Wagenknecht, Lynne E.4 aut |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Watkins, Hugh4 aut |
| 700 | 1 | a Wickremasinghe, Ananda R.4 aut |
| 700 | 1 | a Wu, Tangchun4 aut |
| 700 | 1 | a Kamatani, Yoichiro4 aut |
| 700 | 1 | a Laurie, Cathy C.4 aut |
| 700 | 1 | a Bouchard, Claude4 aut |
| 700 | 1 | a Cooper, Richard S.4 aut |
| 700 | 1 | a Evans, Michele K.4 aut |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Hixson, James4 aut |
| 700 | 1 | a Kardia, Sharon L. R.4 aut |
| 700 | 1 | a Kritchevsky, Stephen B.4 aut |
| 700 | 1 | a Psaty, Bruce M.4 aut |
| 700 | 1 | a van Dam, Rob M.4 aut |
| 700 | 1 | a Arnett, Donna K.4 aut |
| 700 | 1 | a Mook-Kanamori, Dennis O.4 aut |
| 700 | 1 | a Fornage, Myriam4 aut |
| 700 | 1 | a Fox, Ervin R.4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Tai, E. Shyong4 aut |
| 700 | 1 | a Wong, Tien Yin4 aut |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a Reiner, Alex P.4 aut |
| 700 | 1 | a Rotimi, Charles N.4 aut |
| 700 | 1 | a Bierut, Laura J.4 aut |
| 700 | 1 | a Zhu, Xiaofeng4 aut |
| 700 | 1 | a Cupples, L. Adrienne4 aut |
| 700 | 1 | a Province, Michael A.4 aut |
| 700 | 1 | a Rotter, Jerome, I4 aut |
| 700 | 1 | a Franks, Paul W.u Umeå universitet,Avdelningen för medicin,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden; Harvard T. H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, MA, USA4 aut0 (Swepub:umu)pafr0003 |
| 700 | 1 | a Rice, Kenneth4 aut |
| 700 | 1 | a Elliott, Paul4 aut |
| 700 | 1 | a Caulfield, Mark J.4 aut |
| 700 | 1 | a Gauderman, W. James4 aut |
| 700 | 1 | a Munroe, Patricia B.4 aut |
| 700 | 1 | a Rao, Dabeeru C.4 aut |
| 700 | 1 | a Morrison, Alanna C.4 aut |
| 710 | 2 | a Karolinska Institutetb Enheten för biobanksforskning4 org |
| 773 | 0 | t Human Molecular Geneticsd : Oxford University Pressg 28:15, s. 2615-2633q 28:15<2615-2633x 0964-6906x 1460-2083 |
| 856 | 4 | u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644157/pdf/ddz070.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-166416 |
| 856 | 4 8 | u https://doi.org/10.1093/hmg/ddz070 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142200157 |
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