The evolution and changing ecology of the African hominid oral microbiome

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Fältnamn	Indikatorer	Metadata
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001		oai:DiVA.org:uu-445574
003		SwePub
008		210716s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:nrm-4675
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4455742 URI
024	7	a https://doi.org/10.1073/pnas.20216551182 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:nrm:diva-46752 URI
040		a (SwePub)uud (SwePub)nrm
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Yates, James A. Fellowsu Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.;Ludwig Maximilians Univ Munchen, Inst Pre & Protohistor Archaeol & Archaeol Roman, D-80539 Munich, Germany.4 aut
245	1 0	a The evolution and changing ecology of the African hominid oral microbiome
264		c 2021-05-10
264	1	b Proceedings of the National Academy of Sciences (PNAS),c 2021
338		a electronic2 rdacarrier
520		a The oral microbiome plays key roles in human biology, health, and disease, but little is known about the global diversity, variation, or evolution of this microbial community. To better understand the evolution and changing ecology of the human oral microbiome, we analyzed 124 dental biofilm metagenomes from humans, including Neanderthals and Late Pleistocene to present-day modern humans, chimpanzees, and gorillas, as well as New World howler monkeys for comparison. We find that a core microbiome of primarily biofilm structural taxa has been maintained throughout African hominid evolution, and these microbial groups are also shared with howler monkeys, suggesting that they have been important oral members since before the catarrhine-platyrrhine split ca. 40 Mya. However, community structure and individual microbial phylogenies do not closely reflect host relationships, and the dental biofilms of Homo and chimpanzees are distinguished by major taxonomic and functional differences. Reconstructing oral metagenomes from up to 100 thousand years ago, we show that the microbial profiles of both Neanderthals and modern humans are highly similar, sharing functional adaptations in nutrient metabolism. These include an apparent Homo-specific acquisition of salivary amylase-binding capability by oral streptococci, suggesting microbial coadaptation with host diet. We additionally find evidence of shared genetic diversity in the oral bacteria of Neanderthal and Upper Paleolithic modern humans that is not observed in later modern human populations. Differences in the oral microbiomes of African hominids provide insights into human evolution, the ancestral state of the human microbiome, and a temporal framework for understanding microbial health and disease.
650	7	a NATURVETENSKAPx Biologix Evolutionsbiologi0 (SwePub)106152 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Evolutionary Biology0 (SwePub)106152 hsv//eng
650	7	a NATURVETENSKAPx Biologix Mikrobiologi0 (SwePub)106062 hsv//swe
650	7	a NATURAL SCIENCESx Biological Sciencesx Microbiology0 (SwePub)106062 hsv//eng
653		a dental calculus
653		a microbiome
653		a Neanderthal
653		a primate
653		a salivary amylase
653		a Diversity of life
700	1	a Velsko, Irina M.u Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.,Univ Nacl Educac, Dept Prehist & Arqueol, Madrid 28040, Spain.4 aut
700	1	a Aron, Franziskau Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.4 aut
700	1	a Posth, Cosimou Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.;Eberhard Karls Univ Tubingen, Inst Archaeol Sci, D-72070 Tubingen, Germany.4 aut
700	1	a Hofman, Courtney A.u Univ Oklahoma, Dept Anthropol, Norman, OK 73019 USA.;Univ Oklahoma, Lab Mol Anthropol & Microbiome Res, Norman, OK 73019 USA.4 aut
700	1	a Austin, Rita M.u Univ Oklahoma, Dept Anthropol, Norman, OK 73019 USA.;Univ Oklahoma, Lab Mol Anthropol & Microbiome Res, Norman, OK 73019 USA.;Univ Oslo, Nat Hist Museum, N-0562 Oslo, Norway.4 aut
700	1	a Parker, Cody E.u Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.;Arizona State Univ, Sch Human Evolut & Social Change, Tempe, AZ 85287 USA.4 aut
700	1	a Mann, Allison E.u Univ North Texas, Hlth Sci Ctr, Dept Microbiol Immunol & Genet, Ft Worth, TX 76107 USA.4 aut
700	1	a Nagele, Kathrinu Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.4 aut
700	1	a Arthur, Kathryn Weedmanu Univ S Florida, Dept Anthropol, St Petersburg, FL 33701 USA.4 aut
700	1	a Arthur, John W.u Univ S Florida, Dept Anthropol, St Petersburg, FL 33701 USA.4 aut
700	1	a Bauer, Catherine C.u Eberhard Karls Univ Tubingen, Dept Geosci, Palaeobiol, Biogeol, D-72074 Tubingen, Germany.,CNRS, Lab Chronoenvironm, UMR 6249, F-25030 Besancon, France.;Direct Reg Affaires Culturelles DRAC Bourgogne Fr, Serv Reg Archeol Bourgogne Franche Comte, F-25043 Besancon, France.4 aut
700	1	a Crevecoeur, Isabelleu Univ Bordeaux, CNRS, Prehistoire Actuel Culture Environm & Anthropol P, UMR 5199, F-33615 Pessac, France.4 aut
700	1	a Cupillard, Christopheu CNRS, Lab Chronoenvironm, UMR 6249, F-25030 Besancon, France.;Direct Reg Affaires Culturelles DRAC Bourgogne Fr, Serv Reg Archeol Bourgogne Franche Comte, F-25043 Besancon, France.,Calif State Univ Channel Isl, Anthropol Program, Camarillo, CA 93012 USA.,Ludwig Maximilians Univ Munchen, Inst Pre & Protohistor Archaeol & Archaeol Roman, D-80539 Munich, Germany.;Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany.,Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany.;Univ Pais Vasco Euskal Herriko Unibertsitatea, Basque Fdn Sci, Ikerbasque, Grp Invest Prehistoria IT 1223 19, Vitoria 01006, Spain.;Univ Valencia, Dept Prehist Hist & Arqueol, Valencia 46010, Spain.;Univ Cape Town, Dept Geol Sci, ZA-7701 Rondebosch, South Africa.4 aut
700	1	a Curtis, Matthew C.u Calif State Univ Channel Isl, Anthropol Program, Camarillo, CA 93012 USA.4 aut
700	1	a Dalen, Lu Naturhistoriska riksmuseet,Enheten för bioinformatik och genetik,Ctr Palaeogenet, S-10691 Stockholm, Sweden.;Swedish Museum Nat Hist, Dept Bioinformat & Genet, S-10405 Stockholm, Sweden.4 aut0 (Swepub:nrm)lovedale
700	1	a Bonilla, Marta Diaz-Zoritau Eberhard Karls Univ Tubingen, Inst Ur & Fruhgeschichte & Archaol Mittelalters, D-72074 Tubingen, Germany.;Eberhard Karls Univ Tubingen, Sonderforschungsbereiche 1070 Ressourcen Kulturen, D-72074 Tubingen, Germany.4 aut
700	1	a Fernandez-Lomana, J. Carlos Diezu Univ Burgos, Prehist, Dept Hist Geog & Comunicac, Burgos 09001, Spain.4 aut
700	1	a Drucker, Dorothee G.u Eberhard Karls Univ Tubingen, Senckenberg Ctr Human Evolut & Palaeoenviroment, D-72074 Tubingen, Germany.4 aut
700	1	a Escriva, Elena Escribanou Escribano Escriva Clin Dent, Santa Cruz De Tenerife 38003, Spain.,Univ Cape Town, Dept Human Biol, Div Clin Anat & Biol Anthropol, ZA-7925 Cape Town, South Africa.,Forsyth Inst, Dept Microbiol, Cambridge, MA 02142 USA.;Harvard Sch Dent Med, Oral Med Infect & Immun, Boston, MA 02115 USA.4 aut
700	1	a Francken, Michaelu Landesamt Denkmalpflege Regierungsprasidium Stutt, D-78467 Constance, Germany.4 aut
700	1	a Gibbon, Victoria E.u Univ Cape Town, Dept Human Biol, Div Clin Anat & Biol Anthropol, ZA-7925 Cape Town, South Africa.4 aut
700	1	a Morales, Manuel R. Gonzalezu Univ Cantabria Gobierno Cantabria Banco, Inst Int Invest Prehistor Cantabria, Santander 39071, Spain.4 aut
700	1	a Mateu, Ana Grandeu Clin Dent Grande Mateu, Valencia 46004, Spain.4 aut
700	1	a Harvati, Katerinau Eberhard Karls Univ Tubingen, Senckenberg Ctr Human Evolut & Palaeoenviroment, D-72074 Tubingen, Germany.;Eberhard Karls Univ Tubingen, Inst Archaeol Sci, Paleoanthropol, D-72070 Tubingen, Germany.;Eberhard Karls Univ Tubingen, Deutsch Forsch Gemeinschaft Ctr Adv Studies Words, D-72070 Tubingen, Germany.4 aut
700	1	a Henry, Amanda G.u Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.;Leiden Univ, Fac Archaeol, NL-2333CC Leiden, Netherlands.4 aut
700	1	a Humphrey, Louiseu Nat Hist Museum, Ctr Human Evolut Res, London SW7 5BD, England.4 aut
700	1	a Menendez, Mariou Univ Nacl Educac, Dept Prehist & Arqueol, Madrid 28040, Spain.,Univ Oklahoma, Dept Anthropol, Norman, OK 73019 USA.4 aut
700	1	a Mihailovic, Dusanu Univ Belgrade, Fac Philosophy, Dept Archaeol, Belgrade 11000, Serbia.4 aut
700	1	a Peresani, Marcou Univ Ferrara, Dept Humanities, I-44121 Ferrara, Italy.;CNR, Inst Environm Geol & Geoengn, I-20126 Milan, Lombardia, Italy.4 aut
700	1	a Moroder, Sofia Rodriguezu Clin Alboraya 10, Valencia 46010, Spain.4 aut
700	1	a Roksandic, Mirjanau Univ Winnipeg, Dept Anthropol, Winnipeg, MB R3T 3C7, Canada.4 aut
700	1	a Rougier, Heleneu Calif State Univ Northridge, Dept Anthropol, Northridge, CA 91330 USA.4 aut
700	1	a Sazelova, Sandrau Czech Acad Sci, Inst Archaeol Brno, Brno 60200, Czech Republic.4 aut
700	1	a Stock, Jay T.u Western Univ, Dept Anthropol, London, ON N6A 5C2, Canada.;Max Planck Inst Sci Human Hist, Dept Archaeol, D-07745 Jena, Germany.;Univ Cambridge, McDonald Inst Archaeol Res, Cambridge CB2 3ER, England.4 aut
700	1	a Straus, Lawrence Guyu Univ New Mexico, Dept Anthropol, Albuquerque, NM 87131 USA.4 aut
700	1	a Svoboda, Jiriu Czech Acad Sci, Inst Archaeol Brno, Brno 60200, Czech Republic.;Masaryk Univ, Dept Anthropol, Brno 61137, Czech Republic.4 aut
700	1	a Tessmann, Barbarau Stiftung Preuss Kulturbesitz, Museum Vor & Fruhgeschichte Berlin, D-10117 Berlin, Germany.;Berliner Gesell Anthropol Ethnol & Urgeschichte, D-10117 Berlin, Germany.4 aut
700	1	a Walker, Michael J.u Univ Murcia, Dept Zool & Antropol Fis, Murcia 30100, Spain.4 aut
700	1	a Power, Robert C.u Ludwig Maximilians Univ Munchen, Inst Pre & Protohistor Archaeol & Archaeol Roman, D-80539 Munich, Germany.;Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany.4 aut
700	1	a Lewis, Cecil M.u Univ Oklahoma, Dept Anthropol, Norman, OK 73019 USA.4 aut
700	1	a Sankaranarayanan, Krithivasanu Univ Oklahoma, Dept Microbiol & Plant Biol, Norman, OK 73019 USA.4 aut
700	1	a Guschanski, Katerina,c Dr.d 1978-u Uppsala universitet,Zooekologi,Science for Life Laboratory, SciLifeLab,Univ Edinburgh, Sch Biol Sci, Inst Evolutionary Biol, Edinburgh EH9 3FL, Midlothian, Scotland.4 aut0 (Swepub:uu)katgu490
700	1	a Wrangham, Richard W.u Harvard Univ, Dept Human Evolutionary Biol, Cambridge, MA 02138 USA.4 aut
700	1	a Dewhirst, Floyd E.u Forsyth Inst, Dept Microbiol, Cambridge, MA 02142 USA.;Harvard Sch Dent Med, Oral Med Infect & Immun, Boston, MA 02115 USA.4 aut
700	1	a Salazar-Garcia, Domingo C.u Max Planck Inst Evolutionary Anthropol, Dept Human Evolut, D-04103 Leipzig, Germany.;Univ Pais Vasco Euskal Herriko Unibertsitatea, Basque Fdn Sci, Ikerbasque, Grp Invest Prehistoria IT 1223 19, Vitoria 01006, Spain.;Univ Valencia, Dept Prehist Hist & Arqueol, Valencia 46010, Spain.;Univ Cape Town, Dept Geol Sci, ZA-7701 Rondebosch, South Africa.4 aut
700	1	a Krause, Johannesu Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.;Max Planck Inst Evolutionary Anthropol, Dept Archaeogenet, D-04103 Leipzig, Germany.4 aut
700	1	a Herbig, Alexanderu Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.4 aut
700	1	a Warinner, Christinau Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.;Univ Oklahoma, Dept Anthropol, Norman, OK 73019 USA.;Harvard Univ, Dept Anthropol, Cambridge, MA 02138 USA.4 aut
710	2	a Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.;Ludwig Maximilians Univ Munchen, Inst Pre & Protohistor Archaeol & Archaeol Roman, D-80539 Munich, Germany.b Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany.4 org
773	0	t Proceedings of the National Academy of Sciences of the United States of Americad : Proceedings of the National Academy of Sciences (PNAS)g 118:20q 118:20x 0027-8424x 1091-6490
856	4	u https://doi.org/10.1073/pnas.2021655118y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1580852/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://www.pnas.org/content/pnas/118/20/e2021655118.full.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445574
856	4 8	u https://doi.org/10.1073/pnas.2021655118
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:nrm:diva-4675

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Av författaren/redakt...: Yates, James A. ...; Velsko, Irina M.; Aron, Franziska; Posth, Cosimo; Hofman, Courtney ...; Austin, Rita M.; visa fler...; Parker, Cody E.; Mann, Allison E.; Nagele, Kathrin; Arthur, Kathryn ...; Arthur, John W.; Bauer, Catherine ...; Crevecoeur, Isab ...; Cupillard, Chris ...; Curtis, Matthew ...; Dalen, L; Bonilla, Marta D ...; Fernandez-Lomana ...; Drucker, Dorothe ...; Escriva, Elena E ...; Francken, Michae ...; Gibbon, Victoria ...; Morales, Manuel ...; Mateu, Ana Grand ...; Harvati, Katerin ...; Henry, Amanda G.; Humphrey, Louise; Menendez, Mario; Mihailovic, Dusa ...; Peresani, Marco; Moroder, Sofia R ...; Roksandic, Mirja ...; Rougier, Helene; Sazelova, Sandra; Stock, Jay T.; Straus, Lawrence ...; Svoboda, Jiri; Tessmann, Barbar ...; Walker, Michael ...; Power, Robert C.; Lewis, Cecil M.; Sankaranarayanan ...; Guschanski, Kate ...; Wrangham, Richar ...; Dewhirst, Floyd ...; Salazar-Garcia, ...; Krause, Johannes; Herbig, Alexande ...; Warinner, Christ ...; visa färre...

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