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Search: WFRF:(Israelsson Marlen) > (2020) > Reference intervals...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005054naa a2200409 4500
001oai:DiVA.org:oru-109618
003SwePub
008231107s2020 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1096182 URI
0247 a https://doi.org/10.1530/eje-19-08722 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bäcklund, Nilsu Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden4 aut
2451 0a Reference intervals of salivary cortisol and cortisone and their diagnostic accuracy in Cushing’s syndrome
264 1b Bioscientifica,c 2020
338 a print2 rdacarrier
520 a Objective: The challenge of diagnosing Cushing's syndrome (CS) calls for high precision biochemical screening. This study aimed to establish robust reference intervals for, and compare the diagnostic accuracy of, salivary cortisol and cortisone in late-night samples and after a low-dose (1 mg) dexamethasone suppression test (DST).Design and methods: Saliva samples were collected at 08:00 and 23:00 h, and at 08:00 h, after a DST, from 22 patients with CS and from 155 adult reference subjects. We also collected samples at 20:00 and 22:00 h from 78 of the reference subjects. Salivary cortisol and cortisone were analysed with liquid chromatography-tandem mass spectrometry. The reference intervals were calculated as the 2.5th and 97.5th percentiles of the reference population measurements. Diagnostic accuracies of different tests were compared, based on areas under the receiver-operating characteristic curves.Results: The upper reference limits of salivary cortisol and cortisone at 23:00 h were 3.6 nmol/L and 13.5 nmol/L, respectively. Using these reference limits, CS was detected with a sensitivity (95% CI) of 90% (70-99%) and specificity of 96% (91-98%) for cortisol, and a 100% (84-100%) sensitivity and 95% (90-98%) specificity for cortisone. After DST, cortisol and cortisone upper reference limits were 0.79 nmol/L and 3.5 nmol/L, respectively. CS was detected with 95% (75-100%) sensitivity and 96% (92-99%) specificity with cortisol, and 100% (83-100%) sensitivity and 94% (89-97%) specificity with cortisone. No differences in salivary cortisol or cortisone levels were found between samples collected at 22:00 and 23:00 h.Conclusion: Salivary cortisol and cortisone in late-night samples and after DST showed high accuracy for diagnosing CS, salivary cortisone being slightly, but significantly better.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Brattsand, Göranu Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden4 aut
7001 a Israelsson, Marlenu Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden4 aut
7001 a Ragnarsson, Oskaru Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut
7001 a Burman, Piau Department of Endocrinology, Skåne University Hospital, University of Lund, Malmö, Sweden4 aut
7001 a Edén Engström, Brittu Department of Medical Sciences, Endocrinology and Mineral Metabolism, Uppsala University, Uppsala, Sweden4 aut
7001 a Høybye, Charlotteu Department of Molecular Medicine and Surgery, Patient Area Endocrinology and Nephrology, Inflammation and Infection Theme, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden4 aut
7001 a Berinder, Katarinau Department of Molecular Medicine and Surgery, Patient Area Endocrinology and Nephrology, Inflammation and Infection Theme, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden4 aut
7001 a Wahlberg, Jeanette,d 1969-u Department of Endocrinology, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden4 aut0 (Swepub:oru)jewg
7001 a Olsson, Tommyu Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden4 aut
7001 a Dahlqvist, Peru Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden4 aut
7102 a Department of Public Health and Clinical Medicine, Umeå University, Umeå, Swedenb Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden4 org
7730 t European Journal of Endocrinologyd : Bioscientificag 182:6, s. 569-582q 182:6<569-582x 0804-4643x 1479-683X
8564 u https://eje.bioscientifica.com/downloadpdf/journals/eje/182/6/EJE-19-0872.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-109618
8564 8u https://doi.org/10.1530/eje-19-0872

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