WFRF:(Iversen Astrid K.N.)
Sökning: WFRF:(Iversen Astrid K.N.) > The selection lands...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04454naa a2200685 4500 | |
| 001 | oai:gup.ub.gu.se/334798 | |
| 003 | SwePub | |
| 008 | 240528s2024 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3347982 URI |
| 024 | 7 | a https://doi.org/10.1038/s41586-023-06705-12 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Irving-Pease, Evan K.4 aut |
| 245 | 1 0 | a The selection landscape and genetic legacy of ancient Eurasians |
| 264 | 1 | c 2024 |
| 520 | a The Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes 1, we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia. We identify key selection signals related to metabolism, including that selection at the FADS cluster began earlier than previously reported and that selection near the LCT locus predates the emergence of the lactase persistence allele by thousands of years. We also find strong selection in the HLA region, possibly due to increased exposure to pathogens during the Bronze Age. Using ancient individuals to infer local ancestry tracts in over 400,000 samples from the UK Biobank, we identify widespread differences in the distribution of Mesolithic, Neolithic and Bronze Age ancestries across Eurasia. By calculating ancestry-specific polygenic risk scores, we show that height differences between Northern and Southern Europe are associated with differential Steppe ancestry, rather than selection, and that risk alleles for mood-related phenotypes are enriched for Neolithic farmer ancestry, whereas risk alleles for diabetes and Alzheimer’s disease are enriched for Western hunter-gatherer ancestry. Our results indicate that ancient selection and migration were large contributors to the distribution of phenotypic diversity in present-day Europeans. | |
| 650 | 7 | a NATURVETENSKAPx Biologix Genetik0 (SwePub)106092 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Genetics0 (SwePub)106092 hsv//eng |
| 650 | 7 | a HUMANIORAx Historia och arkeologix Arkeologi0 (SwePub)601032 hsv//swe |
| 650 | 7 | a HUMANITIESx History and Archaeologyx Archaeology0 (SwePub)601032 hsv//eng |
| 700 | 1 | a Refoyo-Martínez, Alba4 aut |
| 700 | 1 | a Barrie, William4 aut |
| 700 | 1 | a Ingason, Andrés4 aut |
| 700 | 1 | a Pearson, Alice4 aut |
| 700 | 1 | a Fischer, Anders,d 1951u Gothenburg University,Göteborgs universitet,Institutionen för historiska studier,Department of Historical Studies4 aut0 (Swepub:gu)xfiand |
| 700 | 1 | a Sjögren, Karl-Göran,d 1949u Gothenburg University,Göteborgs universitet,Institutionen för historiska studier,Department of Historical Studies4 aut0 (Swepub:gu)xsjkar |
| 700 | 1 | a Halgren, Alma S.4 aut |
| 700 | 1 | a Macleod, Ruairidh4 aut |
| 700 | 1 | a Demeter, Fabrice4 aut |
| 700 | 1 | a Henriksen, Rasmus A.4 aut |
| 700 | 1 | a Vimala, Tharsika4 aut |
| 700 | 1 | a McColl, Hugh4 aut |
| 700 | 1 | a Vaughn, Andrew H.4 aut |
| 700 | 1 | a Speidel, Leo4 aut |
| 700 | 1 | a Stern, Aaron J.4 aut |
| 700 | 1 | a Scorrano, Gabriele4 aut |
| 700 | 1 | a Ramsøe, Abigail4 aut |
| 700 | 1 | a Schork, Andrew J.4 aut |
| 700 | 1 | a Rosengren, Anders4 aut |
| 700 | 1 | a Zhao, Lei4 aut |
| 700 | 1 | a Kristiansen, Kristian,d 1948u Gothenburg University,Göteborgs universitet,Institutionen för historiska studier,Department of Historical Studies4 aut0 (Swepub:gu)xkrikr |
| 700 | 1 | a Iversen, Astrid K.N.4 aut |
| 700 | 1 | a Fugger, Lars4 aut |
| 700 | 1 | a Sudmant, Peter H.4 aut |
| 700 | 1 | a Lawson, Daniel J.4 aut |
| 700 | 1 | a Durbin, Richard4 aut |
| 700 | 1 | a Korneliussen, Thorfinn4 aut |
| 700 | 1 | a Werge, Thomas4 aut |
| 700 | 1 | a Allentoft, Morten E.4 aut |
| 700 | 1 | a Sikora, Martin4 aut |
| 700 | 1 | a Nielsen, Rasmus4 aut |
| 700 | 1 | a Racimo, Fernando4 aut |
| 700 | 1 | a Willerslev, Eske4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för historiska studier4 org |
| 773 | 0 | t Natureg 625, s. 312-320q 625<312-320x 0028-0836x 1476-4687 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/334798 |
| 856 | 4 8 | u https://doi.org/10.1038/s41586-023-06705-1 |
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