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Potential risks of ...
Potential risks of bone marrow cell transplantation into infarcted hearts
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- Breitbach, Martin (author)
- University of Bonn, Bonn, Germany
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- Bostani, Toktam (author)
- University of Bonn, Bonn, Germany
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- Roell, Wilhelm (author)
- University of Bonn, Bonn, Germany
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- Xia, Ying (author)
- University of Cologne, Cologne, Germany
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- Dewald, Oliver (author)
- University of Bonn, Bonn, Germany
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- Nygren, Jens Martin, 1976- (author)
- Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine,Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
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- Fries, Jochen W. U. (author)
- University of Cologne, Cologne, Germany
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- Tiemann, Klaus (author)
- University of Bonn, Bonn, Germany
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- Bohlen, Heribert (author)
- Axiogenesis AG, Cologne, Germany
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- Hescheler, Juergen (author)
- University of Cologne, Cologne, Germany
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- Welz, Armin (author)
- University of Bonn, Bonn, Germany
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- Bloch, Wilhelm (author)
- German Sport University, Cologne, Germany
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- Jacobsen, Sten Eirik W (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, Lund, Sweden
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- Fleischmann, Bernd K (author)
- University of Bonn, Bonn, Germany
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(creator_code:org_t)
- Washington, DC : American Society of Hematology, 2007
- 2007
- English.
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In: Blood. - Washington, DC : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 110:4, s. 1362-1369
- Related links:
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- Cellular replacement therapy has emerged as a novel strategy for the treatment of heart failure. The aim of our study was to determine the fate of injected mesenchymal stem cells (MSCs) and whole bone marrow (BM) cells in the infarcted heart. MSCs were purified from BM of transgenic mice and characterized using flow cytometry and in vitro differentiation assays. Myocardial infarctions were generated in mice and different cell populations including transgenic MSCs, unfractionated BM cells, or purified hematopoietic progenitors were injected. Encapsulated structures were found in the infarcted areas of a large fraction of hearts after injecting MSCs (22 of 43, 51.2%) and unfractionated BM cells (6 of 46, 13.0%). These formations contained calcifications and/or ossifications. In contrast, no pathological abnormalities were found after injection of purified hematopoietic progenitors (0 of 5, 0.0%), fibroblasts (0 of 5, 0.0%), vehicle only (0 of 30, 0.0%), or cytokine-induced mobilization of BM cells (0 of 35, 0.0%). We conclude that the developmental fate of BM-derived cells is not restricted by the surrounding tissue after myocardial infarction and that the MSC fraction underlies the extended bone formation in the infarcted myocardium. These findings seriously question the biologic basis and clinical safety of using whole BM and in particular MSCs to treat nonhematopoietic disorders.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Animals
- Bone marrow transplantation
- Cell differentiation
- Cultured cells
- Flow cytometry
- Green fluorescent proteins
- Mesenchymal stem cell transplantation
- Mice
- Inbred C57BL mice
- Transgenic mice
- Myocardial infarction
- Risk factors
- Treatment outcome
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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Blood
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- By the author/editor
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Breitbach, Marti ...
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Bostani, Toktam
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Roell, Wilhelm
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Xia, Ying
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Dewald, Oliver
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Nygren, Jens Mar ...
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Fries, Jochen W. ...
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Tiemann, Klaus
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Bohlen, Heribert
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Hescheler, Juerg ...
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Welz, Armin
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Bloch, Wilhelm
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Jacobsen, Sten E ...
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Fleischmann, Ber ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Blood
- By the university
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Halmstad University
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Lund University