WFRF:(Janoueix Lerosey I.)
Sökning: WFRF:(Janoueix Lerosey I.) > BET and CDK Inhibit...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02470naa a2200385 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:149841233 | |
| 003 | SwePub | |
| 008 | 240701s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1498412332 URI |
| 024 | 7 | a https://doi.org/10.3390/cancers141127552 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Sriha, J4 aut |
| 245 | 1 0 | a BET and CDK Inhibition Reveal Differences in the Proliferation Control of Sympathetic Ganglion Neuroblasts and Adrenal Chromaffin Cells |
| 264 | c 2022-06-01 | |
| 264 | 1 | b MDPI AG,c 2022 |
| 520 | a Neuroblastoma arising from the adrenal differ from ganglionic neuroblastoma both genetically and clinically, with adrenal tumors being associated with a more severe prognosis. The different tumor properties may be linked to specific tumor founder cells in adrenal and sympathetic ganglia. To address this question, we first set up cultures of mouse sympathetic neuroblasts and adrenal chromaffin cells. These cultures were then treated with various proliferation inhibitors to identify lineage-specific responses. We show that neuroblast and chromaffin cell proliferation was affected by WNT, ALK, IGF1, and PRC2/EZH2 signaling inhibitors to a similar extent. However, differential effects were observed in response to bromodomain and extraterminal (BET) protein inhibitors (JQ1, GSK1324726A) and to the CDK-7 inhibitor THZ1, with BET inhibitors preferentially affecting chromaffin cells, and THZ1 preferentially affecting neuroblasts. The differential dependence of chromaffin cells and neuroblasts on BET and CDK signaling may indicate different mechanisms during tumor initiation in sympathetic ganglia and adrenal. | |
| 700 | 1 | a Louis-Brennetot, C4 aut |
| 700 | 1 | a Pierre-Eugene, C4 aut |
| 700 | 1 | a Baulande, S4 aut |
| 700 | 1 | a Raynal, V4 aut |
| 700 | 1 | a Kramdi, A4 aut |
| 700 | 1 | a Adameyko, Iu Karolinska Institutet4 aut |
| 700 | 1 | a Ernsberger, U4 aut |
| 700 | 1 | a Deller, T4 aut |
| 700 | 1 | a Delattre, O4 aut |
| 700 | 1 | a Janoueix-Lerosey, I4 aut |
| 700 | 1 | a Rohrer, H4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Cancersd : MDPI AGg 14:11q 14:11x 2072-6694 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:149841233 |
| 856 | 4 8 | u https://doi.org/10.3390/cancers14112755 |
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- Sriha, J
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- Baulande, S
- Raynal, V
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- Adameyko, I
- Ernsberger, U
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- Rohrer, H
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