WFRF:(Jansson Jan Håkan)
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Elevated plasma homocysteine : cause or consequence of myocardial infarction?
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- Hultdin, Johan (author)
- Umeå universitet,Klinisk kemi
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- Thøgersen, Ann Margreth (author)
- Umeå universitet,Medicin
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- Jansson, Jan-Håkan (author)
- Umeå universitet,Medicin
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- (creator_code:org_t)
- Wiley, 2004
- 2004
- English.
- In: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 256:6, s. 491-498
- Journal article (peer-reviewed)
Abstract
Subject headings
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- OBJECTIVES: To determine whether a first myocardial infarction leads to increased plasma homocysteine concentrations and whether the association between homocysteine and myocardial infarction was greater at follow-up compared with baseline. DESIGN: A population-based, prospective, nested case-referent study. SETTING: Screening took place at the nearest health survey centre in northern Sweden. SUBJECTS: Of more than 36,000 persons screened, 78 developed a first myocardial infarction (average 18 months after sampling). Fifty of these had participated in a follow-up health survey (average 8(1/2) years between surveys) and were sex- and age-matched with 56 referents. MAIN OUTCOME MEASURES: Comparison of plasma homocysteine levels in case and referent subjects before and after development of a first myocardial infarction. RESULTS: No statistically significant difference was found between cases and referents regarding homocysteine at baseline or follow-up. Plasma homocysteine and plasma creatinine increased significantly, and plasma albumin decreased significantly over time. Conditional univariate logistic regression indicated that high homocysteine at follow-up but not baseline was associated with first myocardial infarction (OR 2.49; 95% CI: 1.03-6.02), but the relation disappeared in multivariate analyses including plasma creatinine and plasma albumin. High plasma creatinine remained associated with first myocardial infarction at both baseline (OR 2.94; 95% CI: 1.05-8.21) and follow-up (OR 3.38; 95% CI: 1.21-9.48). CONCLUSION: In this study, first myocardial infarction did not cause increased plasma homocysteine concentration.
Keyword
- Case-Control Studies
- Creatinine/blood
- Female
- Homocysteine/*blood
- Humans
- Male
- Middle Aged
- Myocardial Infarction/*blood
- Prospective Studies
- Risk Factors
- Serum Albumin/analysis
- Smoking/adverse effects
Publication and Content Type
- ref (subject category)
- art (subject category)
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