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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005711naa a2200493 4500
001oai:lup.lub.lu.se:0e046b0e-dc24-4f16-9ce9-7a7026dd3be9
003SwePub
008190428s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/0e046b0e-dc24-4f16-9ce9-7a7026dd3be92 URI
0247 a https://doi.org/10.1111/joim.129032 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Arora, Geeti Pu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Deep Hospital, Ludhiana4 aut0 (Swepub:lu)med-gea
2451 0a Phenotypic and genotypic differences between Indian and Scandinavian women with gestational diabetes mellitus
264 c 2019-04-29
264 1b Wiley,c 2019
520 a OBJECTIVE: Gestational diabetes mellitus (GDM) is a transient form of diabetes characterized by impaired insulin secretion and action during pregnancy. Population-based differences in prevalence exist which could be explained by phenotypic and genetic differences. The aim of this study was to examine these differences in pregnant women from Punjab, India and Scandinavia.METHODS: 85 GDM/T2D loci in European and/or Indian populations from previous studies were assessed for association with GDM based on Swedish GDM criteria in 4018 Punjabi Indian and 507 Swedish pregnant women. Selected loci were replicated in Scandinavian cohorts, Radiel (N=398, Finnish), STORK/STORK-G (N=780, Norwegian).RESULTS: Punjabi Indian women had higher GDM prevalence, lower insulin secretion and better insulin sensitivity than Swedish women. There were significant frequency differences of GDM/T2D risk alleles between both populations. rs7178572 at HMG20A, previously associated with GDM in South Indian and European women was replicated in North Indian women. The T2D risk SNP rs11605924 in the CRY2 gene was associated with increased GDM risk in Scandinavian but decreased risk in Punjabi Indian women. No other overlap was seen between GDM loci in both populations.CONCLUSIONS: GDM is more common in Indian than Swedish women, which partially can be attributed to differences in insulin secretion and action. There was marked heterogeneity in the GDM phenotypes between the populations which could only partially be explained by genetic differences. This article is protected by copyright. All rights reserved.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Åkerlund, Mikaelu Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups4 aut0 (Swepub:lu)medk-mak
7001 a Brøns, Charlotteu Copenhagen University Hospital4 aut
7001 a Moen, Gunn-Helenu University of Oslo4 aut
7001 a Wasenius, Niko Su University of Helsinki4 aut
7001 a Sommer, Christineu Oslo university hospital4 aut
7001 a Jenum, Anne Ku University of Oslo4 aut
7001 a Almgren, Peteru Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Diabetes - Cardiovascular Disease,Lund University Research Groups,Cardiovascular Research - Hypertension4 aut0 (Swepub:lu)endo-pal
7001 a Thaman, Richa Gu Deep Hospital, Ludhiana4 aut
7001 a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor
7001 a Eriksson, Johanu University of Helsinki4 aut
7001 a Qvigstad, Elisabethu Oslo university hospital4 aut
7001 a Birkeland, Kåreu University of Oslo4 aut
7001 a Berntorp, Kerstinu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)endo-kbe
7001 a Vaag, Allan Au Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Copenhagen University Hospital,AstraZeneca, Sweden4 aut0 (Swepub:lu)med-ava
7001 a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM)4 aut0 (Swepub:lu)endo-lgr
7001 a Prasad, Rashmi Bu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-rpa
7102 a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
7730 t Journal of Internal Medicined : Wileyg 286:2, s. 192-206q 286:2<192-206x 1365-2796x 0954-6820
8564 u http://dx.doi.org/10.1111/joim.12903y FULLTEXT
8564 u https://helda.helsinki.fi/bitstream/10138/312929/1/Phenotypic_and_genotypic_differences_between_Indian_and_Scandinavian_women_with_gestational_diabetes_mellitus.pdf
8564 8u https://lup.lub.lu.se/record/0e046b0e-dc24-4f16-9ce9-7a7026dd3be9
8564 8u https://doi.org/10.1111/joim.12903

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