Sökning: WFRF:(Johansson Helene 1962 )
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Impaired myocardial...
Impaired myocardial t-PA release in patients with coronary artery disease
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- Österlund, Barbro (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Jern, Sverker, 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin,Institute of Medicine, Department of Emergeny and Cardiovascular Medicine
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- Jern, Christina, 1962 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Seeman-Lodding, Heléne, 1957 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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- Östman, Margareta (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Johansson, Göran (författare)
- Umeå universitet,Anestesiologi och intensivvård
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- Biber, Björn, 1944 (författare)
- Gothenburg University,Göteborgs universitet,Umeå universitet,Anestesiologi och intensivvård,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
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(creator_code:org_t)
- Wiley, 2008
- 2008
- Engelska.
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Ingår i: Acta Anaesthesiol Scand. - : Wiley. - 1399-6576. ; 52:10, s. 1375-84
- Relaterad länk:
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http://www.ncbi.nlm....
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https://umu.diva-por... (primary) (Raw object)
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http://umu.diva-port...
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https://urn.kb.se/re...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- AIMS: Myocardial ischemia remains a significant perioperative complication in coronary artery disease (CAD) patients. We hypothesized that noxious stimuli during major surgery are associated with an acute release of tissue-type plasminogen activator (t-PA) into the coronary circulation, and that this response is reduced by CAD. METHODS AND RESULTS: Two patient groups, with (n=14) and without (n=8) CAD, were studied during the initial phase of heart surgery. After retrograde great cardiac vein catheterizations during closed-chest conditions, coronary arterial-venous concentration gradients of t-PA and plasminogen activator inhibitor type-1 (PAI-1) were measured together with coronary blood flow measurements, allowing derivation of coronary net release rates. Pre-surgery atrial pacing, performed to evaluate the influence of increases in heart rate (+ 40 beats/min) and coronary blood flow (+ 80 ml/min), did not significantly alter coronary net release of t-PA or PAI-1 in either patient group. Sternotomy induced a prominent increase in coronary net release of both total and active t-PA in the non-CAD group. This response was considerably reduced in the CAD group. CONCLUSIONS: This study provides the first analysis of coronary t-PA release during major surgery and demonstrates a deficient local endothelial t-PA release in patients with CAD. This suggests a reduced local fibrinolytic capacity in CAD patients, which may explain the increased risk for coronary thrombosis in this patient group.
Nyckelord
- Aged
- Blood Pressure
- Cardiac Pacing
- Artificial/methods
- Cardiac Surgical Procedures/methods
- Catheterization
- Swan-Ganz
- Coronary Artery Disease/*metabolism
- Coronary Thrombosis/prevention & control
- Coronary Vessels/metabolism
- Endothelium
- Vascular/secretion
- Female
- Heart Rate
- Humans
- Male
- Middle Aged
- Myocardial Ischemia/*metabolism
- Plasminogen Activator Inhibitor 1/*blood
- Tissue Plasminogen Activator/*blood
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Österlund, Barbr ...
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Jern, Sverker, 1 ...
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Jern, Christina, ...
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Seeman-Lodding, ...
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Östman, Margaret ...
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Johansson, Göran
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Biber, Björn, 19 ...
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- Artiklar i publikationen
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Acta Anaesthesio ...
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Acta Anaesthesio ...
- Av lärosätet
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Umeå universitet
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Göteborgs universitet