Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures

Zirakzadeh, AA (author)

Almamoun, R (author)

Sjoholm, LK (author)

Dahlstrom, J (author)

Sjoberg, J (author)

Winqvist, O (author)

Xu, DW (author)

Straat, K (author)

(creator_code:org_t)

2020-12-09
2020
English.
In: Frontiers in oncology. - : Frontiers Media SA. - 2234-943X. ; 10, s. 598872-

Related links:: https://www.frontier...; show more...; http://kipublication...; https://doi.org/10.3...; show less...

Abstract Subject headings

We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differences in DNA methylation signatures when comparing the two HL-affected triplets with the non-affected triplet. The differences were observed in naïve B-cells and marginal zone-like B-cells. DNA methylation differences were also detected when comparing each of the HL-affected triplets against each other. Even though we cannot determine whether treatment and/or disease triggered the observed differences, we believe our data are important on behalf of forthcoming studies, and that it might provide important clues for a better understanding of HL pathogenesis.

By the author/editor: Xia, CY; Olsen, TK; Zirakzadeh, AA; Almamoun, R; Sjoholm, LK; Dahlstrom, J; show more...; Sjoberg, J; Claesson, HE; Johnsen, JI; Winqvist, O; Xu, DW; Ekstrom, TJ; Bjorkholm, M; Straat, K; show less...

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