Sökning: WFRF:(Joulin Virginie) > (2007) > Haplotype-based ana...
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000 | 05025naa a2200877 4500 | |
001 | oai:lup.lub.lu.se:1b16a995-f901-4e8b-a428-207da98519e1 | |
003 | SwePub | |
008 | 160401s2007 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/6698832 URI |
024 | 7 | a https://doi.org/10.1158/1055-9965.EPI-06-06172 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Sinilnikova, Olga M.4 aut |
245 | 1 0 | a Haplotype-based analysis of common variation in the acetyl-CoA carboxyiase alpha gene and breast cancer risk: A case-control study nested within the European prospective investigation into cancer and nutrition |
264 | 1 | c 2007 |
520 | a A key fatty acid synthesis enzyme, acetyl-CoA carboxylase alpha(ACC-alpha), has been shown to be highly expressed in human breast cancer and other tumor types and also to specifically interact with the protein coded by one of two major breast cancer susceptibility genes BRCA1. We used a comprehensive haplotype analysis to examine the contribution of the ACC-alpha common genetic variation (allele frequency > 5%) to breast cancer in a case-control study (1,588 cases/2,600 controls) nested within the European Prospective Investigation into Cancer and Nutrition. We identified 21 haplotypetagging polymorphisms efficiently capturing common variation within 325 kb of ACC-alpha and surrounding sequences using genotype data from the HapMap project and our resequencing data. We found an effect on overall risk of breast cancer in homozygous carriers of one common haplotype [odds ratio (OR), 1.74; 95% confidence interval (95% CI), 1.03-2.94]. When the data were subdivided by menopausal status, we found statistical evidence of heterogeneity for two other common haplotypes (P value for heterogeneity = 0.016 and 0.045). In premenopausal women, the carriers of these haplotypes, compared with noncarriers, had an altered risk of breast cancer (OR, 0.70; 95% CI, 0.53-0.92 and OR, 1.35; 95% CI, 1.04-1.76). These findings were not significant after adjustment for multiple testing and therefore should be considered as preliminary and evaluated in larger independent studies. However, they suggest a possible role of the ACC-alpha common sequence variants in susceptibility to breast cancer and encourage studies of other genes involved in fatty acid synthesis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a McKay, James D.4 aut |
700 | 1 | a Tavtigian, Sean V.4 aut |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a DeSilva, Deepika4 aut |
700 | 1 | a Biessy, Carine4 aut |
700 | 1 | a Monnier, Stephanie4 aut |
700 | 1 | a Dossus, Laure4 aut |
700 | 1 | a Boillot, Catherine4 aut |
700 | 1 | a Gioia, Lydie4 aut |
700 | 1 | a Hughes, David J.4 aut |
700 | 1 | a Jensen, Majken K.4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Olsen, Anja4 aut |
700 | 1 | a Clavel-Chapelon, Francoise4 aut |
700 | 1 | a Chajes, Veronique4 aut |
700 | 1 | a Joulin, Virginie4 aut |
700 | 1 | a Linseisen, Jakob4 aut |
700 | 1 | a Chang-Claude, Jenny4 aut |
700 | 1 | a Boeing, Heiner4 aut |
700 | 1 | a Dahm, Stephan4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Trichopoulos, Dimitrios4 aut |
700 | 1 | a Koliva, Maria4 aut |
700 | 1 | a Khaw, Kay-Tee4 aut |
700 | 1 | a Bingham, Sheila4 aut |
700 | 1 | a Allen, Naomi E.4 aut |
700 | 1 | a Key, Timothy4 aut |
700 | 1 | a Palli, Domenico4 aut |
700 | 1 | a Panico, Salvatore4 aut |
700 | 1 | a Berrino, Franco4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Vineis, Paolo4 aut |
700 | 1 | a Bueno-de-Mesquita, H. Bas4 aut |
700 | 1 | a Peeters, Petra H.4 aut |
700 | 1 | a van Gils, Carla H.4 aut |
700 | 1 | a Lund, Eiliv4 aut |
700 | 1 | a Pera, Guillem4 aut |
700 | 1 | a Quiros, Jose Ramon4 aut |
700 | 1 | a Dorronsoro, Miren4 aut |
700 | 1 | a Martinez Garcia, Carmen4 aut |
700 | 1 | a Tormo, Maria-Jose4 aut |
700 | 1 | a Ardanaz, Eva4 aut |
700 | 1 | a Hallmans, Goran4 aut |
700 | 1 | a Lenner, Per4 aut |
700 | 1 | a Berglund, Goran4 aut |
700 | 1 | a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma |
700 | 1 | a Riboli, Elio4 aut |
700 | 1 | a Lenoir, Gilbert M.4 aut |
700 | 1 | a Kaaks, Rudolf4 aut |
710 | 2 | a Kirurgib Forskargrupper vid Lunds universitet4 org |
773 | 0 | t Cancer Epidemiology Biomarkers & Preventiong 16:3, s. 409-415q 16:3<409-415x 1538-7755 |
856 | 4 | u http://dx.doi.org/10.1158/1055-9965.EPI-06-0617x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/669883 |
856 | 4 8 | u https://doi.org/10.1158/1055-9965.EPI-06-0617 |
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