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Spatial Transcripto...
Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease
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- Fernandez Navarro, Jose (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Croteau, Deborah L. (författare)
- Laboratory of Molecular Gerontology, National Institute on Aging, Baltimore, MD 21224, USA
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- Jurek, Aleksandra (författare)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Andrusivova, Zaneta (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Yang, Beiming (författare)
- Laboratory of Molecular Gerontology, National Institute on Aging, Baltimore,MD 21224, USA
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- Wang, Yue (författare)
- Laboratory of MolecularGerontology, NationalInstitute on Aging, Baltimore,MD 21224, USA
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- Ogedegbe, Benjamin (författare)
- Laboratory of MolecularGerontology, NationalInstitute on Aging, Baltimore,MD 21224, USA
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- Riaz, Tahira (författare)
- Unit for Genome Dynamics,Department of Microbiology,University of Oslo and OsloUniversity Hospital, 0372Oslo, Norway
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- Støen, Mari (författare)
- Unit for Genome Dynamics,Department of Microbiology,University of Oslo and OsloUniversity Hospital, 0372Oslo, Norway
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- Desler, Claus (författare)
- Center for Healthy Aging,Department of Cellular andMolecular Medicine,University of Copenhagen,2200 Copenhagen, Denmark
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- Rasmussen, Lene Juel (författare)
- Center for Healthy Aging,Department of Cellular andMolecular Medicine,University of Copenhagen,2200 Copenhagen, Denmark
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- Tønjum, Tone (författare)
- Unit for Genome Dynamics,Department of Microbiology,University of Oslo and OsloUniversity Hospital, 0372Oslo, Norway
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- Galas, Marie-Christine (författare)
- University of Lille, Inserm,CHU Lille, UMR-S 1172 -Centre de RechercheJean-Pierre AUBERTNeurosciences et Cancer,59000 Lille, France
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- Lundeberg, Joakim (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Bohr, Vilhelm A. (författare)
- Unit for Genome Dynamics,Department of Microbiology,University of Oslo and OsloUniversity Hospital, 0372Oslo, Norway
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(creator_code:org_t)
- Elsevier Inc. 2020
- 2020
- Engelska.
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Ingår i: iScience. - : Elsevier Inc.. - 2589-0042. ; 23:10
- Relaterad länk:
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https://doi.org/10.1...
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Cellular Neuroscience; Omics; Transcriptomics Alzheimer disease (AD) is a devastating neurological disease associated with progressive loss of mental skills and cognitive and physical functions whose etiology is not completely understood. Here, our goal was to simultaneously uncover novel and known molecular targets in the structured layers of the hippocampus and olfactory bulbs that may contribute to early hippocampal synaptic deficits and olfactory dysfunction in AD mice. Spatially resolved transcriptomics was used to identify high-confidence genes that were differentially regulated in AD mice relative to controls. A diverse set of genes that modulate stress responses and transcription were predominant in both hippocampi and olfactory bulbs. Notably, we identify Bok, implicated in mitochondrial physiology and cell death, as a spatially downregulated gene in the hippocampus of mouse and human AD brains. In summary, we provide a rich resource of spatially differentially expressed genes, which may contribute to understanding AD pathology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Medicinsk bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Cellular Neuroscience
- Omics
- Transcriptomics
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Fernandez Navarr ...
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Croteau, Deborah ...
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Jurek, Aleksandr ...
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Andrusivova, Zan ...
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Yang, Beiming
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Wang, Yue
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Ogedegbe, Benjam ...
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Riaz, Tahira
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Støen, Mari
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Desler, Claus
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Rasmussen, Lene ...
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Tønjum, Tone
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Galas, Marie-Chr ...
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Lundeberg, Joaki ...
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Bohr, Vilhelm A.
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