Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

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Fältnamn	Indikatorer	Metadata
000		04931naa a2200865 4500
001		oai:DiVA.org:umu-190623
003		SwePub
008		211220s2021 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1906232 URI
024	7	a https://doi.org/10.3390/nu130931322 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Aglago, Elom K.4 aut
245	1 0	a Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study
264		c 2021-09-08
264	1	b MDPI,c 2021
338		a electronic2 rdacarrier
520		a Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: Nε-carboxy-methyllysine (CML), Nε-carboxyethyllysine (CEL), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated in 450,111 participants (median follow-up = 13 years, with 6162 CRC cases) by matching to a detailed published European food composition database. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of dAGEs with CRC were computed using multivariable-adjusted Cox regression models. Inverse CRC risk associations were observed for CML (HR comparing extreme quintiles: HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00) and MG-H1 (HRQ5vs.Q1 = 0.92, 95% CI = 0.85-1.00), but not for CEL (HRQ5vs.Q1 = 0.97, 95% CI = 0.89-1.05). The associations did not differ by sex or anatomical location of the tumor. Contrary to the initial hypothesis, our findings suggest an inverse association between dAGEs and CRC risk. More research is required to verify these findings and better differentiate the role of dAGEs from that of endogenously produced AGEs and their precursor compounds in CRC development.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a advanced glycation end-products
653		a colorectal cancer
653		a dietary exposure
653		a dietary glycation compounds
700	1	a Mayén, Ana-Lucia4 aut
700	1	a Knaze, Viktoria4 aut
700	1	a Freisling, Heinz4 aut
700	1	a Fedirko, Veronika4 aut
700	1	a Hughes, David J.4 aut
700	1	a Jiao, Li4 aut
700	1	a Eriksen, Anne Kirstine4 aut
700	1	a Tjønneland, Anne4 aut
700	1	a Boutron-Ruault, Marie-Christine4 aut
700	1	a Rothwell, Joseph A.4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Kaaks, Rudolf4 aut
700	1	a Katzke, Verena4 aut
700	1	a Schulze, Matthias B.4 aut
700	1	a Birukov, Anna4 aut
700	1	a Palli, Domenico4 aut
700	1	a Sieri, Sabina4 aut
700	1	a Santucci de Magistris, Maria4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Ricceri, Fulvio4 aut
700	1	a Bueno-de-Mesquita, Bas4 aut
700	1	a Derksen, Jeroen W. G.4 aut
700	1	a Skeie, Guri4 aut
700	1	a Gram, Inger Torhild4 aut
700	1	a Sandanger, Torkjel4 aut
700	1	a Quirós, J. Ramón4 aut
700	1	a Luján-Barroso, Leila4 aut
700	1	a Sánchez, Maria-Jose4 aut
700	1	a Amiano, Pilar4 aut
700	1	a Chirlaque, María-Dolores4 aut
700	1	a Gurrea, Aurelio Barricarte4 aut
700	1	a Johansson, Ingegerdu Umeå universitet,Onkologi4 aut0 (Swepub:umu)injo0003
700	1	a Manjer, Jonas4 aut
700	1	a Perez-Cornago, Aurora4 aut
700	1	a Weiderpass, Elisabete4 aut
700	1	a Gunter, Marc J.4 aut
700	1	a Heath, Alicia K.4 aut
700	1	a Schalkwijk, Casper G.4 aut
700	1	a Jenab, Mazda4 aut
710	2	a Umeå universitetb Onkologi4 org
773	0	t Nutrientsd : MDPIg 13:9q 13:9x 2072-6643
856	4	u https://doi.org/10.3390/nu13093132y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1621699/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://www.mdpi.com/2072-6643/13/9/3132/pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190623
856	4 8	u https://doi.org/10.3390/nu13093132

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By the author/editor: Aglago, Elom K.; Mayén, Ana-Lucia; Knaze, Viktoria; Freisling, Heinz; Fedirko, Veronik ...; Hughes, David J.; show more...; Jiao, Li; Eriksen, Anne Ki ...; Tjønneland, Anne; Boutron-Ruault, ...; Rothwell, Joseph ...; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthia ...; Birukov, Anna; Palli, Domenico; Sieri, Sabina; Santucci de Magi ...; Tumino, Rosario; Ricceri, Fulvio; Bueno-de-Mesquit ...; Derksen, Jeroen ...; Skeie, Guri; Gram, Inger Torh ...; Sandanger, Torkj ...; Quirós, J. Ramón; Luján-Barroso, L ...; Sánchez, Maria-J ...; Amiano, Pilar; Chirlaque, María ...; Gurrea, Aurelio ...; Johansson, Ingeg ...; Manjer, Jonas; Perez-Cornago, A ...; Weiderpass, Elis ...; Gunter, Marc J.; Heath, Alicia K.; Schalkwijk, Casp ...; Jenab, Mazda; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Nutrition and Di ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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