Sökning: WFRF:(Kellert Lars) > Penumbral Rescue by...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 06534naa a2201333 4500 | |
001 | oai:gup.ub.gu.se/335516 | |
003 | SwePub | |
008 | 240910s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3355162 URI |
024 | 7 | a https://doi.org/10.1177/174749302311852752 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Poli, Sven4 aut |
245 | 1 0 | a Penumbral Rescue by normobaric O?=?O administration in patients with ischemic stroke and target mismatch proFile (PROOF): Study protocol of a phase IIb trial |
264 | 1 | c 2024 |
520 | a Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve the ischemic penumbra until revascularization occurs.Aims: PROOF investigates the use of normobaric oxygen (NBO) therapy within 6 h of symptom onset/notice for brain-protective bridging until endovascular revascularization of acute intracranial anterior-circulation occlusion.Methods and design: Randomized (1:1), standard treatment-controlled, open-label, blinded endpoint, multicenter adaptive phase IIb trial.Study outcomes: Primary outcome is ischemic core growth (mL) from baseline to 24 h (intention-to-treat analysis). Secondary efficacy outcomes include change in NIHSS from baseline to 24 h, mRS at 90 days, cognitive and emotional function, and quality of life. Safety outcomes include mortality, intracranial hemorrhage, and respiratory failure. Exploratory analyses of imaging and blood biomarkers will be conducted.Sample size: Using an adaptive design with interim analysis at 80 patients per arm, up to 456 participants (228 per arm) would be needed for 80% power (one-sided alpha 0.05) to detect a mean reduction of ischemic core growth by 6.68 mL, assuming 21.4 mL standard deviation.Discussion: By enrolling endovascular thrombectomy candidates in an early time window, the trial replicates insights from preclinical studies in which NBO showed beneficial effects, namely early initiation of near 100% inspired oxygen during short temporary ischemia. Primary outcome assessment at 24 h on follow-up imaging reduces variability due to withdrawal of care and early clinical confounders such as delayed extubation and aspiration pneumonia. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Normobaric oxygen therapy | |
653 | a NBO | |
653 | a hyperoxygenation | |
653 | a neuroprotection | |
653 | a penumbra | |
653 | a ischemic stroke | |
653 | a thrombectomy | |
700 | 1 | a Mbroh, Joshua4 aut |
700 | 1 | a Baron, Jean-Claude4 aut |
700 | 1 | a Singhal, Aneesh B.4 aut |
700 | 1 | a Strbian, Daniel4 aut |
700 | 1 | a Molina, Carlos4 aut |
700 | 1 | a Lemmens, Robin4 aut |
700 | 1 | a Turc, Guillaume4 aut |
700 | 1 | a Mikulik, Robert4 aut |
700 | 1 | a Michel, Patrik4 aut |
700 | 1 | a Tatlisumak, Turgutu Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xtatlt |
700 | 1 | a Audebert, Heinrich J.4 aut |
700 | 1 | a Dichgans, Martin4 aut |
700 | 1 | a Veltkamp, Roland4 aut |
700 | 1 | a Huesing, Johannes4 aut |
700 | 1 | a Graessner, Holm4 aut |
700 | 1 | a Fiehler, Jens4 aut |
700 | 1 | a Montaner, Joan4 aut |
700 | 1 | a Adeyemi, Adedolapo Kamaldeen4 aut |
700 | 1 | a Althaus, Katharina4 aut |
700 | 1 | a Arenillas, Juan F.4 aut |
700 | 1 | a Bender, Benjamin4 aut |
700 | 1 | a Benedikt, Frank4 aut |
700 | 1 | a Broocks, Gabriel4 aut |
700 | 1 | a Burghaus, Ina4 aut |
700 | 1 | a Cardona, Pere4 aut |
700 | 1 | a Deb-Chatterji, Milani4 aut |
700 | 1 | a Cvikova, Martina4 aut |
700 | 1 | a Defreyne, Luc4 aut |
700 | 1 | a De Herdt, Veerle4 aut |
700 | 1 | a Detante, Olivier4 aut |
700 | 1 | a Ernemann, Ulrike4 aut |
700 | 1 | a Flottmann, Fabian4 aut |
700 | 1 | a Guillamon, Lidia Garcia4 aut |
700 | 1 | a Glauch, Monika4 aut |
700 | 1 | a Gomez-Exposito, Alexandra4 aut |
700 | 1 | a Gory, Benjamin4 aut |
700 | 1 | a Grand, Sylvie Sylvie4 aut |
700 | 1 | a Harsany, Michal4 aut |
700 | 1 | a Hauser, Till Karsten4 aut |
700 | 1 | a Heck, Olivier4 aut |
700 | 1 | a Hemelsoet, Dimitri4 aut |
700 | 1 | a Hennersdorf, Florian4 aut |
700 | 1 | a Hoppe, Julia4 aut |
700 | 1 | a Kalmbach, Pia4 aut |
700 | 1 | a Kellert, Lars4 aut |
700 | 1 | a Kohrmann, Martin4 aut |
700 | 1 | a Kowarik, Markus4 aut |
700 | 1 | a Lara-Rodriguez, Blanca4 aut |
700 | 1 | a Legris, Loic4 aut |
700 | 1 | a Lindig, Tobias4 aut |
700 | 1 | a Luntz, Steffen4 aut |
700 | 1 | a Lusk, Jay4 aut |
700 | 1 | a Mac Grory, Brian4 aut |
700 | 1 | a Manger, Andreas4 aut |
700 | 1 | a Martinez-Majander, Nicolas4 aut |
700 | 1 | a Mengel, Annerose4 aut |
700 | 1 | a Meyne, Johannes4 aut |
700 | 1 | a Muller, Susanne4 aut |
700 | 1 | a Mundiyanapurath, Sibu4 aut |
700 | 1 | a Naggara, Olivier4 aut |
700 | 1 | a Nedeltchev, Krassen4 aut |
700 | 1 | a Nguyen, Thanh N.4 aut |
700 | 1 | a Nilsson, Maike A.4 aut |
700 | 1 | a Obadia, Michael4 aut |
700 | 1 | a Poli, Khouloud4 aut |
700 | 1 | a Purrucker, Jan C.4 aut |
700 | 1 | a Raty, Silja4 aut |
700 | 1 | a Richard, Sebastien4 aut |
700 | 1 | a Richter, Hardy4 aut |
700 | 1 | a Schilte, Clotilde4 aut |
700 | 1 | a Schlemm, Eckhard4 aut |
700 | 1 | a Stohr, Linda4 aut |
700 | 1 | a Stolte, Benjamin4 aut |
700 | 1 | a Sykora, Marek4 aut |
700 | 1 | a Thomalla, Goetz4 aut |
700 | 1 | a Tomppo, Liisa4 aut |
700 | 1 | a van Horn, Noel4 aut |
700 | 1 | a Zeller, Julia4 aut |
700 | 1 | a Ziemann, Ulf4 aut |
700 | 1 | a Zuern, Christine S.4 aut |
700 | 1 | a Hartig, Florian4 aut |
700 | 1 | a Tuennerhoff, Johannes4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap4 org |
773 | 0 | t INTERNATIONAL JOURNAL OF STROKEg 19:1, s. 120-126q 19:1<120-126x 1747-4930x 1747-4949 |
856 | 4 8 | u https://gup.ub.gu.se/publication/335516 |
856 | 4 8 | u https://doi.org/10.1177/17474930231185275 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy