Search: WFRF:(Kittner Steven J.)
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White matter hyperi...
White matter hyperintensity burden in acute stroke patients differs by ischemic stroke subtype
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- Giese, Anne Katrin (author)
- Broad Institute,Harvard Medical School
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- Schirmer, Markus D. (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Harvard Medical School,Massachusetts Institute of Technology
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- Dalca, Adrian V. (author)
- Massachusetts Institute of Technology,Massachusetts General Hospital
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- Sridharan, Ramesh (author)
- Massachusetts Institute of Technology
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- Donahue, Kathleen L. (author)
- Harvard Medical School
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- Nardin, Marco (author)
- Harvard Medical School
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- Irie, Robert (author)
- Massachusetts General Hospital
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- McIntosh, Elissa C. (author)
- Massachusetts General Hospital
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- Mocking, Steven J.T. (author)
- Massachusetts General Hospital
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- Xu, Huichun (author)
- Slotervaart Hospital
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- Cole, John W. (author)
- Slotervaart Hospital
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- Giralt-Steinhauer, Eva (author)
- Autonomous University of Barcelona
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- Jimenez-Conde, Jordi (author)
- Autonomous University of Barcelona
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- Jern, Christina (author)
- University of Gothenburg
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- Kleindorfer, Dawn O. (author)
- University of Cincinnati College of Medicine
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- Lemmens, Robin (author)
- University Hospitals Leuven,Catholic University of Leuven
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- Wasselius, Johan (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,Stroke Imaging Research group,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Neuroradiology,Lund University Research Groups
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- Lindgren, Arne (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk strokeforskning,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Stroke Research Group,Lund University Research Groups
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- Rundek, Tatjana (author)
- University of Miami
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- Sacco, Ralph L. (author)
- University of Miami
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- Schmidt, Reinhold (author)
- Medical University of Graz
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- Sharma, Pankaj (author)
- Royal Holloway University of London,Ashford And St Peter's Hospital
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- Slowik, Agnieszka (author)
- Jagiellonian University
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- Thijs, Vincent (author)
- Austin Health,University of Melbourne
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- Worrall, Bradford B. (author)
- Massachusetts General Hospital,University of Virginia
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- Woo, Daniel (author)
- University of Cincinnati College of Medicine
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- Kittner, Steven J. (author)
- Slotervaart Hospital
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- McArdle, Patrick F. (author)
- Slotervaart Hospital
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- Mitchell, Braxton D. (author)
- Slotervaart Hospital
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- Rosand, Jonathan (author)
- Broad Institute,Harvard Medical School,Massachusetts General Hospital
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- Meschia, James F. (author)
- Mayo Clinic Florida
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- Wu, Ona (author)
- Harvard Medical School,Massachusetts General Hospital
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- Golland, Polina (author)
- Massachusetts Institute of Technology
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- Rost, Natalia S. (author)
- Harvard Medical School
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(creator_code:org_t)
- 2020
- 2020
- English 10 s.
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In: Neurology. - 0028-3878. ; 95:1, s. 79-88
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- ObjectiveTo examine etiologic stroke subtypes and vascular risk factor profiles and their association with white matter hyperintensity (WMH) burden in patients hospitalized for acute ischemic stroke (AIS).MethodsFor the MRI Genetics Interface Exploration (MRI-GENIE) study, we systematically assembled brain imaging and phenotypic data for 3,301 patients with AIS. All cases underwent standardized web tool-based stroke subtyping with the Causative Classification of Ischemic Stroke (CCS). WMH volume (WMHv) was measured on T2 brain MRI scans of 2,529 patients with a fully automated deep-learning trained algorithm. Univariable and multivariable linear mixed-effects modeling was carried out to investigate the relationship of vascular risk factors with WMHv and CCS subtypes.ResultsPatients with AIS with large artery atherosclerosis, major cardioembolic stroke, small artery occlusion (SAO), other, and undetermined causes of AIS differed significantly in their vascular risk factor profile (all p < 0.001). Median WMHv in all patients with AIS was 5.86 cm3 (interquartile range 2.18-14.61 cm3) and differed significantly across CCS subtypes (p < 0.0001). In multivariable analysis, age, hypertension, prior stroke, smoking (all p < 0.001), and diabetes mellitus (p = 0.041) were independent predictors of WMHv. When adjusted for confounders, patients with SAO had significantly higher WMHv compared to those with all other stroke subtypes (p < 0.001).ConclusionIn this international multicenter, hospital-based cohort of patients with AIS, we demonstrate that vascular risk factor profiles and extent of WMH burden differ by CCS subtype, with the highest lesion burden detected in patients with SAO. These findings further support the small vessel hypothesis of WMH lesions detected on brain MRI of patients with ischemic stroke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Neurology
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Giese, Anne Katr ...
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Schirmer, Markus ...
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Dalca, Adrian V.
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Sridharan, Rames ...
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Donahue, Kathlee ...
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Nardin, Marco
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Irie, Robert
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McIntosh, Elissa ...
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Mocking, Steven ...
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Xu, Huichun
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Cole, John W.
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Giralt-Steinhaue ...
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Jimenez-Conde, J ...
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Jern, Christina
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Kleindorfer, Daw ...
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Lemmens, Robin
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Wasselius, Johan
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Lindgren, Arne
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Rundek, Tatjana
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Sacco, Ralph L.
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Schmidt, Reinhol ...
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Sharma, Pankaj
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Slowik, Agnieszk ...
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Thijs, Vincent
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Worrall, Bradfor ...
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Woo, Daniel
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Kittner, Steven ...
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McArdle, Patrick ...
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Mitchell, Braxto ...
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Rosand, Jonathan
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Meschia, James F ...
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Wu, Ona
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Golland, Polina
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Rost, Natalia S.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Neurology
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Lund University