Search: WFRF:(Kleinjans Jos C. S.)
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Blood-based omic pr...
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Chatziioannou, AristotelisNational Hellenic Research Foundation
(author)
Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-02-22
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Springer Science and Business Media LLC,2017
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:917acb58-71f7-4fa3-aa3a-2651bf57cb1a
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https://lup.lub.lu.se/record/917acb58-71f7-4fa3-aa3a-2651bf57cb1aURI
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https://doi.org/10.1038/srep42870DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131858URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.
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Georgiadis, PanagiotisNational Hellenic Research Foundation
(author)
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Hebels, Dennie G.Maastricht University
(author)
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Liampa, IreneNational Hellenic Research Foundation
(author)
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Valavanis, IoannisNational Hellenic Research Foundation
(author)
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Bergdahl, Ingvar A.Umeå universitet,Umeå University,Yrkes- och miljömedicin,Enheten för biobanksforskning(Swepub:umu)inbe0001
(author)
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Johansson, AndersLund University,Lunds universitet,Umeå universitet,Umeå University,Näringsforskning,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-bjo
(author)
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Palli, DomenicoCancer Research and Prevention Institute (ISPO)
(author)
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Chadeau-Hyam, MarcImperial College London
(author)
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Siskos, Alexandros P.Imperial College London
(author)
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Keun, HectorImperial College London
(author)
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Botsivali, MariaNational Hellenic Research Foundation
(author)
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De Kok, Theo M C MMaastricht University
(author)
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Pérez, Almudena EspínMaastricht University
(author)
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Kleinjans, Jos C SMaastricht University
(author)
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Vineis, PaoloImperial College London
(author)
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Kyrtopoulos, Soterios A.National Hellenic Research Foundation
(author)
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Gottschalk, RalphMaastricht University
(author)
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Van Leeuwen, DanitsjaMaastricht University
(author)
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Timmermans, LeenMaastricht University
(author)
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Bendinelli, BenedettaCancer Research and Prevention Institute (ISPO)
(author)
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Kelly, RachelImperial College London
(author)
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Vermeulen, RoelUtrecht University
(author)
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Portengen, LutzenUtrecht University
(author)
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Saberi Hosnijeh, FatemehUtrecht University
(author)
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Melin, BeatriceUmeå University
(author)
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Hallmans, GoranUmeå University
(author)
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Lenner, PerUmeå University
(author)
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Athersuch, Toby J.Imperial College London
(author)
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Kogevinas, ManolisCentre for Research in Environmental Epidemiology
(author)
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Stephanou, Euripides G.University of Crete
(author)
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Myridakis, AntonisUniversity of Crete
(author)
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Fazzo, LuciaItalian National Institute of Health (ISS)
(author)
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De Santis, MarcoItalian National Institute of Health (ISS)
(author)
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Comba, PietroItalian National Institute of Health (ISS)
(author)
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Kiviranta, HannuFinnish National Institute for Health and Welfare
(author)
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Rantakokko, PanuFinnish National Institute for Health and Welfare
(author)
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Airaksinen, RiikkaFinnish National Institute for Health and Welfare
(author)
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Ruokojarvi, PaiviFinnish National Institute for Health and Welfare
(author)
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Gilthorpe, MarkUniversity of Leeds
(author)
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Fleming, SarahUniversity of Leeds
(author)
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Fleming, ThomasUniversity of Leeds
(author)
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Tu, Yu KangUniversity of Leeds
(author)
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Jönsson, Bo ALund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-bjo
(author)
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Lundh, ThomasLund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups(Swepub:lu)ymed-tlu
(author)
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Chen, Wei-JungNational Taiwan University
(author)
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Lee, Wen ChungNational Taiwan University
(author)
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Hsiao, Chuhsing KateNational Taiwan University
(author)
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Chien, Kuo LiongNational Taiwan University
(author)
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Kuo, Po HsiuNational Taiwan University
(author)
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Hung, HungNational Taiwan University
(author)
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Liao, Shu FenNational Taiwan University
(author)
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National Hellenic Research FoundationMaastricht University
(creator_code:org_t)
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In:Scientific Reports: Springer Science and Business Media LLC72045-2322
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Chatziioannou, A ...
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Georgiadis, Pana ...
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Hebels, Dennie G ...
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Liampa, Irene
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Valavanis, Ioann ...
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Bergdahl, Ingvar ...
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Johansson, Ander ...
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Palli, Domenico
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Chadeau-Hyam, Ma ...
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Siskos, Alexandr ...
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Botsivali, Maria
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De Kok, Theo M C ...
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Pérez, Almudena ...
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Kleinjans, Jos C ...
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Vineis, Paolo
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Kyrtopoulos, Sot ...
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Gottschalk, Ralp ...
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Van Leeuwen, Dan ...
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Portengen, Lutze ...
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Saberi Hosnijeh, ...
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Ruokojarvi, Paiv ...
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Gilthorpe, Mark
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Umeå University