Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

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Fältnamn	Indikatorer	Metadata
000		08191naa a2201045 4500
001		oai:lup.lub.lu.se:917acb58-71f7-4fa3-aa3a-2651bf57cb1a
003		SwePub
008		170308s2017 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:DiVA.org:umu-131858
024	7	a https://lup.lub.lu.se/record/917acb58-71f7-4fa3-aa3a-2651bf57cb1a2 URI
024	7	a https://doi.org/10.1038/srep428702 DOI
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1318582 URI
040		a (SwePub)lud (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Chatziioannou, Aristotelisu National Hellenic Research Foundation4 aut
245	1 0	a Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases
264		c 2017-02-22
264	1	b Springer Science and Business Media LLC,c 2017
520		a We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Beroendelära0 (SwePub)303092 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Substance Abuse0 (SwePub)303092 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
700	1	a Georgiadis, Panagiotisu National Hellenic Research Foundation4 aut
700	1	a Hebels, Dennie G.u Maastricht University4 aut
700	1	a Liampa, Ireneu National Hellenic Research Foundation4 aut
700	1	a Valavanis, Ioannisu National Hellenic Research Foundation4 aut
700	1	a Bergdahl, Ingvar A.u Umeå universitet,Umeå University,Yrkes- och miljömedicin,Enheten för biobanksforskning4 aut0 (Swepub:umu)inbe0001
700	1	a Johansson, Andersu Lund University,Lunds universitet,Umeå universitet,Umeå University,Näringsforskning,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-bjo
700	1	a Palli, Domenicou Cancer Research and Prevention Institute (ISPO)4 aut
700	1	a Chadeau-Hyam, Marcu Imperial College London4 aut
700	1	a Siskos, Alexandros P.u Imperial College London4 aut
700	1	a Keun, Hectoru Imperial College London4 aut
700	1	a Botsivali, Mariau National Hellenic Research Foundation4 aut
700	1	a De Kok, Theo M C Mu Maastricht University4 aut
700	1	a Pérez, Almudena Espínu Maastricht University4 aut
700	1	a Kleinjans, Jos C Su Maastricht University4 aut
700	1	a Vineis, Paolou Imperial College London4 aut
700	1	a Kyrtopoulos, Soterios A.u National Hellenic Research Foundation4 aut
700	1	a Gottschalk, Ralphu Maastricht University4 aut
700	1	a Van Leeuwen, Danitsjau Maastricht University4 aut
700	1	a Timmermans, Leenu Maastricht University4 aut
700	1	a Bendinelli, Benedettau Cancer Research and Prevention Institute (ISPO)4 aut
700	1	a Kelly, Rachelu Imperial College London4 aut
700	1	a Vermeulen, Roelu Utrecht University4 aut
700	1	a Portengen, Lutzenu Utrecht University4 aut
700	1	a Saberi Hosnijeh, Fatemehu Utrecht University4 aut
700	1	a Melin, Beatriceu Umeå University4 aut
700	1	a Hallmans, Goranu Umeå University4 aut
700	1	a Lenner, Peru Umeå University4 aut
700	1	a Athersuch, Toby J.u Imperial College London4 aut
700	1	a Kogevinas, Manolisu Centre for Research in Environmental Epidemiology4 aut
700	1	a Stephanou, Euripides G.u University of Crete4 aut
700	1	a Myridakis, Antonisu University of Crete4 aut
700	1	a Fazzo, Luciau Italian National Institute of Health (ISS)4 aut
700	1	a De Santis, Marcou Italian National Institute of Health (ISS)4 aut
700	1	a Comba, Pietrou Italian National Institute of Health (ISS)4 aut
700	1	a Kiviranta, Hannuu Finnish National Institute for Health and Welfare4 aut
700	1	a Rantakokko, Panuu Finnish National Institute for Health and Welfare4 aut
700	1	a Airaksinen, Riikkau Finnish National Institute for Health and Welfare4 aut
700	1	a Ruokojarvi, Paiviu Finnish National Institute for Health and Welfare4 aut
700	1	a Gilthorpe, Marku University of Leeds4 aut
700	1	a Fleming, Sarahu University of Leeds4 aut
700	1	a Fleming, Thomasu University of Leeds4 aut
700	1	a Tu, Yu Kangu University of Leeds4 aut
700	1	a Jönsson, Bo Au Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-bjo
700	1	a Lundh, Thomasu Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups4 aut0 (Swepub:lu)ymed-tlu
700	1	a Chen, Wei-Jungu National Taiwan University4 aut
700	1	a Lee, Wen Chungu National Taiwan University4 aut
700	1	a Hsiao, Chuhsing Kateu National Taiwan University4 aut
700	1	a Chien, Kuo Liongu National Taiwan University4 aut
700	1	a Kuo, Po Hsiuu National Taiwan University4 aut
700	1	a Hung, Hungu National Taiwan University4 aut
700	1	a Liao, Shu Fenu National Taiwan University4 aut
710	2	a National Hellenic Research Foundationb Maastricht University4 org
773	0	t Scientific Reportsd : Springer Science and Business Media LLCg 7q 7x 2045-2322
856	4	u http://dx.doi.org/10.1038/srep42870x freey FULLTEXT
856	4	u https://www.nature.com/articles/srep42870.pdf
856	4	u https://doi.org/10.1038/srep42870y Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1076591/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://lup.lub.lu.se/record/917acb58-71f7-4fa3-aa3a-2651bf57cb1a
856	4 8	u https://doi.org/10.1038/srep42870
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131858

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Av författaren/redakt...: Chatziioannou, A ...; Georgiadis, Pana ...; Hebels, Dennie G ...; Liampa, Irene; Valavanis, Ioann ...; Bergdahl, Ingvar ...; visa fler...; Johansson, Ander ...; Palli, Domenico; Chadeau-Hyam, Ma ...; Siskos, Alexandr ...; Keun, Hector; Botsivali, Maria; De Kok, Theo M C ...; Pérez, Almudena ...; Kleinjans, Jos C ...; Vineis, Paolo; Kyrtopoulos, Sot ...; Gottschalk, Ralp ...; Van Leeuwen, Dan ...; Timmermans, Leen; Bendinelli, Bene ...; Kelly, Rachel; Vermeulen, Roel; Portengen, Lutze ...; Saberi Hosnijeh, ...; Melin, Beatrice; Hallmans, Goran; Lenner, Per; Athersuch, Toby ...; Kogevinas, Manol ...; Stephanou, Eurip ...; Myridakis, Anton ...; Fazzo, Lucia; De Santis, Marco; Comba, Pietro; Kiviranta, Hannu; Rantakokko, Panu; Airaksinen, Riik ...; Ruokojarvi, Paiv ...; Gilthorpe, Mark; Fleming, Sarah; Fleming, Thomas; Tu, Yu Kang; Jönsson, Bo A; Lundh, Thomas; Chen, Wei-Jung; Lee, Wen Chung; Hsiao, Chuhsing ...; Chien, Kuo Liong; Kuo, Po Hsiu; Hung, Hung; Liao, Shu Fen; visa färre...

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