Sökning: WFRF:(Klenerman Paul) > CD161 Defines a Tra...
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000 | 03413naa a2200565 4500 | |
001 | oai:DiVA.org:su-110749 | |
003 | SwePub | |
008 | 141217s2014 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-1107492 URI |
024 | 7 | a https://doi.org/10.1016/j.celrep.2014.09.0452 DOI |
040 | a (SwePub)su | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Fergusson, Joannah R.4 aut |
245 | 1 0 | a CD161 Defines a Transcriptional and Functional Phenotype across Distinct Human T Cell Lineages |
264 | 1 | b Elsevier BV,c 2014 |
338 | a print2 rdacarrier | |
500 | a AuthorCount:22; | |
520 | a The C-type lectin CD161 is expressed by a large proportion of human T lymphocytes of all lineages, including a population known as mucosal-associated invariant T (MAIT) cells. To understand whether different T cell subsets expressing CD161 have similar properties, we examined these populations in parallel using mass cytometry and mRNA microarray approaches. The analysis identified a conserved CD161++/MAIT cell transcriptional signature enriched in CD161+CD8+ T cells, which can be extended to CD161+ CD4+ and CD161+TCR gamma delta+ T cells. Furthermore, this led to the identification of a shared innate-like, TCR-independent response to interleukin (IL)-12 plus IL-18 by different CD161-expressing T cell populations. This response was independent of regulation by CD161, which acted as a costimulatory molecule in the context of T cell receptor stimulation. Expression of CD161 hence identifies a transcriptional and functional phenotype, shared across human T lymphocytes and independent of both T cell receptor (TCR) expression and cell lineage. | |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
700 | 1 | a Smith, Kira E.4 aut |
700 | 1 | a Fleming, Vicki M.4 aut |
700 | 1 | a Rajoriya, Neil4 aut |
700 | 1 | a Newell, Evan W.4 aut |
700 | 1 | a Simmons, Ruth4 aut |
700 | 1 | a Marchi, Emanuele4 aut |
700 | 1 | a Björkander, Sophiau Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)sobj9073 |
700 | 1 | a Kang, Yu-Hoi4 aut |
700 | 1 | a Swadling, Leo4 aut |
700 | 1 | a Kurioka, Ayako4 aut |
700 | 1 | a Sahgal, Natasha4 aut |
700 | 1 | a Lockstone, Helen4 aut |
700 | 1 | a Baban, Dilair4 aut |
700 | 1 | a Freeman, Gordon J.4 aut |
700 | 1 | a Sverremark-Ekström, Evau Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut4 aut0 (Swepub:su)esver |
700 | 1 | a Davis, Mark M.4 aut |
700 | 1 | a Davenport, Miles P.4 aut |
700 | 1 | a Venturi, Vanessa4 aut |
700 | 1 | a Ussher, James E.4 aut |
700 | 1 | a Willberg, Christian B.4 aut |
700 | 1 | a Klenerman, Paul4 aut |
710 | 2 | a Stockholms universitetb Institutionen för molekylär biovetenskap, Wenner-Grens institut4 org |
773 | 0 | t Cell Reportsd : Elsevier BVg 9:3, s. 1075-1088q 9:3<1075-1088x 2211-1247 |
856 | 4 | u https://doi.org/10.1016/j.celrep.2014.09.045y Fulltext |
856 | 4 | u https://doi.org/10.1016/j.celrep.2014.09.045 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-110749 |
856 | 4 8 | u https://doi.org/10.1016/j.celrep.2014.09.045 |
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