WFRF:(Koutsky L.)
Sökning: WFRF:(Koutsky L.) > Effect of prophylac...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04625naa a2200697 4500 | |
| 001 | oai:lup.lub.lu.se:2ef87d9c-51d5-4d07-a1bf-ffdb8aeeb76e | |
| 003 | SwePub | |
| 008 | 160401s2007 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:12012870 | |
| 024 | 7 | a https://lup.lub.lu.se/record/6644722 URI |
| 024 | 7 | a https://doi.org/10.1016/S0140-6736(07)60852-62 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:120128702 URI |
| 040 | a (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Villa, L.4 aut |
| 245 | 1 0 | a Effect of prophylactic human papillomavirus L1 virus-like-particle vaccine on risk of cervical intraepithelial neoplasia grade 2, grade 3, and adenocarcinoma in situ: a combined analysis of four randomised clinical trials |
| 264 | 1 | c 2007 |
| 520 | a Background Cervical cancer and its obligate precursors, cervical intraepithelial neoplasia grades 2 and 3 (CIN2/3), and adenocarcinona in situ (AIS), are caused by oncogenic human papillomavirus (HPV). In this combined analysis of four clinical trials we assessed the effect of prophylactic HPV vaccination on these diseases. Methods 20 583 women aged 16-26 years were randomised to receive quadrivalent HPV6/11/16/18 vaccine (n=9087), its HPV16 vaccine component (n=1204), or placebo (n=10292). They underwent periodic Papanicolaou testing, with colposcopy or biopsy for detected abnormalities. The primary composite endpoint was the combined incidence of HPV16/18-related CIN2/3, AIS, or cervical cancer. These trials are registered at ClinicalTrials.gov, numbers NCT00365378, NCT00365716, NCT00092521, and NCT00092534. Findings Mean follow-up was 3.0 years (SD 0.66) after first dose. In women negative for HPV16 or HPV18 infection during the vaccination regimen (n=17129, per protocol), vaccine efficacy was 99% for the primary endpoint (95% Cl 93-100), meeting the statistical criterion for success. In an intention-to-treat analysis of all randomised women (including those who were HPV16/18 naive or HPV16/18-infected at day 1), efficacy was 44% (95% Cl 31-55); all but one case in vaccine recipients occurred in women infected with HPV16 or HPV18 before vaccination. In a second intention-to-treat analysis we noted an 18% reduction (95% CI 7-29) in the overall rate of CIN2/3 or AIS due to any HPV type. Interpretation Administration of HPV vaccine to HPV-naive women, and women who are already sexually active, could substantially reduce the incidence of HPV16/18-related cervical precancers and cervical cancer. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
| 700 | 1 | a Perez, G.4 aut |
| 700 | 1 | a Kjaer, S.4 aut |
| 700 | 1 | a Lehtinen, M.4 aut |
| 700 | 1 | a Paavonen, J.4 aut |
| 700 | 1 | a Munoz, N.4 aut |
| 700 | 1 | a Sigurdsson, K.4 aut |
| 700 | 1 | a Hernandez-Avila, M.4 aut |
| 700 | 1 | a Iversen, O. E.4 aut |
| 700 | 1 | a Thoresen, S.4 aut |
| 700 | 1 | a Garcia, P.4 aut |
| 700 | 1 | a Majewski, S.4 aut |
| 700 | 1 | a Tay, E. H.4 aut |
| 700 | 1 | a Bosch, F. X.4 aut |
| 700 | 1 | a Dillner, Joakimu Karolinska Institutet,Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)mikr-jdi |
| 700 | 1 | a Olsson, S. E.u Karolinska Institutet4 aut |
| 700 | 1 | a Ault, K.4 aut |
| 700 | 1 | a Brown, D.4 aut |
| 700 | 1 | a Ferris, D.4 aut |
| 700 | 1 | a Giuliano, A.4 aut |
| 700 | 1 | a Koutsky, L.4 aut |
| 700 | 1 | a Kurman, R.4 aut |
| 700 | 1 | a Myers, E.4 aut |
| 700 | 1 | a Barr, E.4 aut |
| 700 | 1 | a Boslego, J.4 aut |
| 700 | 1 | a Bryan, J.4 aut |
| 700 | 1 | a Esser, M.4 aut |
| 700 | 1 | a Hesley, T.4 aut |
| 700 | 1 | a Lupinacci, L.4 aut |
| 700 | 1 | a Railkar, R.4 aut |
| 700 | 1 | a Sings, H.4 aut |
| 700 | 1 | a Taddeo, F.4 aut |
| 700 | 1 | a Thornton, A.4 aut |
| 710 | 2 | a Klinisk mikrobiologi, Malmöb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t The Lancetg 369:9576, s. 1861-1868q 369:9576<1861-1868x 1474-547X |
| 856 | 4 | u http://dx.doi.org/10.1016/S0140-6736(07)60852-6y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/664472 |
| 856 | 4 8 | u https://doi.org/10.1016/S0140-6736(07)60852-6 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:12012870 |
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- Villa, L.
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- Iversen, O. E.
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- Garcia, P.
- Majewski, S.
- Tay, E. H.
- Bosch, F. X.
- Dillner, Joakim
- Olsson, S. E.
- Ault, K.
- Brown, D.
- Ferris, D.
- Giuliano, A.
- Koutsky, L.
- Kurman, R.
- Myers, E.
- Barr, E.
- Boslego, J.
- Bryan, J.
- Esser, M.
- Hesley, T.
- Lupinacci, L.
- Railkar, R.
- Sings, H.
- Taddeo, F.
- Thornton, A.
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