Global analysis of A-to-I RNA editing reveals association with common disease variants

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Kovacic Jason C.) > Global analysis of ...

LIBRIS Formathandbok (Information om MARC21)

Fältnamn	Indikatorer	Metadata
000		04736naa a2200577 4500
001		oai:DiVA.org:uu-350627
003		SwePub
008		180521s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:137846680
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3506272 URI
024	7	a https://doi.org/10.7717/peerj.44662 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1378466802 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Franzen, Oscaru Karolinska Institutet,Karolinska Inst, Integrated Cardio Metab Ctr, Huddinge, Sweden.4 aut
245	1 0	a Global analysis of A-to-I RNA editing reveals association with common disease variants
264		c 2018-03-06
264	1	b PeerJ,c 2018
338		a electronic2 rdacarrier
520		a RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6 million A-to-I edits were identified in 62% of all protein-coding transcripts. mRNA recoding was extremely rare; only 11 novel recoding sites were uncovered. Thirty single nucleotide polymorphisms from genome-wide association studies were associated with RNA editing; one that influences type 2 diabetes (rs2028299) was associated with editing in ARPIN. Twenty-five genes, including LRP11 and PLIN5, had editing sites that were associated with plasma lipid levels. Our findings provide new insights into the genetic regulation of RNA editing and establish a rich catalogue for further exploration of this process.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng
653		a RNA editing
653		a Gene expression
653		a Quantitative trait loci
653		a RNA-seq
653		a Bioinformatics
653		a Biostatistics
700	1	a Ermel, Railiu Tartu Univ Hosp, Dept Cardiac Surg, Tartu, Estonia.4 aut
700	1	a Sukhavasi, Katyayaniu Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.4 aut
700	1	a Jain, Rajeevu Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.4 aut
700	1	a Jain, Anamikau Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.4 aut
700	1	a Betsholtz, Christeru Karolinska Institutet,Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Integrated Cardio Metab Ctr, Huddinge, Sweden4 aut0 (Swepub:uu)chbet517
700	1	a Giannarelli, Chiarau Icahn Sch Med Mt Sinai, Cardiovasc Res Ctr, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.4 aut
700	1	a Kovacic, Jason C.u Icahn Sch Med Mt Sinai, Cardiovasc Res Ctr, New York, NY 10029 USA.4 aut
700	1	a Ruusalepp, Arnou Tartu Univ Hosp, Dept Cardiac Surg, Tartu, Estonia.;Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.;Clin Gene Networks AB, Stockholm, Sweden.4 aut
700	1	a Skogsberg, Josefinu Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Solna, Sweden.4 aut
700	1	a Hao, Keu Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.4 aut
700	1	a Schadt, Eric E.u Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.;Clin Gene Networks AB, Stockholm, Sweden.4 aut
700	1	a Bjoerkegren, Johan L. M.u Karolinska Institutet,Karolinska Inst, Integrated Cardio Metab Ctr, Huddinge, Sweden.;Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.;Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.;Clin Gene Networks AB, Stockholm, Sweden.4 aut
710	2	a Karolinska Institutetb Karolinska Inst, Integrated Cardio Metab Ctr, Huddinge, Sweden.4 org
773	0	t PeerJd : PeerJg 6q 6x 2167-8359
856	4	u https://doi.org/10.7717/peerj.4466y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1208939/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://doi.org/10.7717/peerj.4466
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-350627
856	4 8	u https://doi.org/10.7717/peerj.4466
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:137846680

Hitta via bibliotek

PeerJ (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Franzen, Oscar; Ermel, Raili; Sukhavasi, Katya ...; Jain, Rajeev; Jain, Anamika; Betsholtz, Chris ...; visa fler...; Giannarelli, Chi ...; Kovacic, Jason C ...; Ruusalepp, Arno; Skogsberg, Josef ...; Hao, Ke; Schadt, Eric E.; Bjoerkegren, Joh ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Cell och molekyl ...

Artiklar i publikationen: PeerJ

Av lärosätet: Uppsala universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se