WFRF:(Kozlova Elena N.)
Sökning: WFRF:(Kozlova Elena N.) > Central neuron-glia...
LIBRIS Formathandbok (Information om MARC21)
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03225naa a2200265 4500 | |
| 001 | oai:DiVA.org:uu-62557 | |
| 003 | SwePub | |
| 008 | 081017s1998 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-625572 URI |
| 024 | 7 | a https://doi.org/10.1016/S0301-0082(97)00093-22 DOI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Aldskogius, Håkanu Uppsala universitet,Institutionen för neurovetenskap,Neuroanatomy4 aut0 (Swepub:uu)hakaalds |
| 245 | 1 0 | a Central neuron-glial and glial-glial interactions following axon injury |
| 264 | 1 | c 1998 |
| 338 | a print2 rdacarrier | |
| 520 | a Axon injury rapidly activates microglial and astroglial cells close to the axotomized neurons. Following motor axon injury, astrocytes upregulate within hour(s) the gap junction protein connexin-43, and within one day glial fibrillary acidic protein (GFAP). Concomitantly, microglial cells proliferate and migrate towards the axotomized neuron perikarya. Analogous responses occur in central termination territories of peripherally injured sensory ganglion cells. The activated microglia express a number of inflammatory and immune mediators. When neuron degeneration occurs, microglia act as phagocytes. This is uncommon after peripheral nerve injury in the adult mammal, however, and the functional implications of the glial cell responses in this situation are unclear. When central axons are injured, the glial cell responses around the affected neuron perikarya appears to be minimal or absent, unless neuron degeneration occurs. Microglia proliferate, and astrocytes upregulate GFAP along central axons undergoing anterograde, Wallerian, degeneration. Although microglia develop into phagocytes, they eliminate the disintegrating myelin very slowly, presumably because they fail to release molecules which facilitate phagocytosis. During later stages of Wallerian degeneration, oligodendrocytes express clusterin, a glycoprotein implicated in several conditions of cell degeneration. A hypothetical scheme for glial cell activation following axon injury is discussed, implying the injured neurons initially interact with adjacent astrocytes. Subsequently, neighbouring resting microglia are activated. These glial reactions are amplified by paracrine and autocrine mechanisms, in which cytokines appear to be important mediators. The specific functional properties of the activated glial cells will determine their influence on neuronal survival, axon regeneration, and synaptic plasticity. The control of the induction and progression of these responses are therefore likely to be critical for the outcome of, for example, neurotrauma, brain ischemia and chronic neurodegenerative diseases. | |
| 700 | 1 | a Kozlova, Elena N.u Uppsala universitet,Institutionen för neurovetenskap,Neuroanatomy4 aut |
| 710 | 2 | a Uppsala universitetb Institutionen för neurovetenskap4 org |
| 773 | 0 | t Progress in Neurobiologyg 55:1, s. 1-26q 55:1<1-26x 0301-0082x 1873-5118 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-62557 |
| 856 | 4 8 | u https://doi.org/10.1016/S0301-0082(97)00093-2 |
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