Sökning: WFRF:(Kwak Brenda R.) > Human venous valve ...
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000 | 05773naa a2200601 4500 | |
001 | oai:DiVA.org:uu-359802 | |
003 | SwePub | |
008 | 180924s2017 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3598022 URI |
024 | 7 | a https://doi.org/10.1084/jem.201608752 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Lyons, Oliveru St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut |
245 | 1 0 | a Human venous valve disease caused by mutations in FOXC2 and GJC2 |
264 | c 2017-07-19 | |
264 | 1 | b Rockefeller University Press,c 2017 |
338 | a electronic2 rdacarrier | |
520 | a Venous valves (VVs) prevent venous hypertension and ulceration. We report that FOXC2 and GJC2 mutations are associated with reduced VV number and length. In mice, early VV formation is marked by elongation and reorientation ("organization") of Prox1(hi) endothelial cells by postnatal day 0. The expression of the transcription factors Foxc2 and Nfatc1 and the gap junction proteins Gjc2, Gja1, and Gja4 were temporospatially regulated during this process. Foxc2 and Nfatc1 were coexpressed at P0, and combined Foxc2 deletion with calcineurin-Nfat inhibition disrupted early Prox1(hi) endothelial organization, suggesting cooperative Foxc2-Nfatc1 patterning of these events. Genetic deletion of Gjc2, Gja4, or Gja1 also disrupted early VV Prox1(hi) endothelial organization at postnatal day 0, and this likely underlies the VV defects seen in patients with GJC2 mutations. Knockout of Gja4 or Gjc2 resulted in reduced proliferation of Prox1(hi) valve-forming cells. At later stages of blood flow, Foxc2 and calcineurin-Nfat signaling are each required for growth of the valve leaflets, whereas Foxc2 is not required for VV maintenance. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Saha, Prakashu St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut |
700 | 1 | a Seet, Christopheru St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut |
700 | 1 | a Kuchta, Adamu Guys & St Thomas NHS Fdn Trust, Dept Ultrason Angiol, London, England4 aut |
700 | 1 | a Arnold, Andrewu Guys & St Thomas NHS Fdn Trust, Dept Ultrason Angiol, London, England4 aut |
700 | 1 | a Grover, Stevenu Harvard Med Sch, Boston, MA USA;Beth Israel Deaconess Med Ctr, Div Hemostasis & Thrombosis, Boston, MA 02215 USA4 aut |
700 | 1 | a Rashbrook, Victoriau St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut |
700 | 1 | a Sabine, Amelieu Univ Lausanne, Div Expt Pathol, Ctr Hosp Univ Vaudois, Epalinges, Switzerland;Ludwig Inst Canc Res, Dept Fundamental Oncol, Zurich, Switzerland4 aut |
700 | 1 | a Vizcay-Barrena, Gemau Kings Coll London, Ctr Ultrastruct Imaging, London, England4 aut |
700 | 1 | a Patel, Ashu St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut |
700 | 1 | a Ludwinski, Francescau St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut |
700 | 1 | a Padayachee, Soundrieu Guys & St Thomas NHS Fdn Trust, Dept Ultrason Angiol, London, England4 aut |
700 | 1 | a Kume, Tsutomuu Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Inst, Evanston, IL USA4 aut |
700 | 1 | a Kwak, Brenda R.u Univ Geneva, Dept Pathol & Immunol, Geneva, Switzerland4 aut |
700 | 1 | a Brice, Glenu St George Hosp, South West Thames Reg Genet Serv, London, England4 aut |
700 | 1 | a Mansour, Saharu St George Hosp, South West Thames Reg Genet Serv, London, England4 aut |
700 | 1 | a Ostergaard, Piau St George Hosp, Cardiovasc & Cell Sci Inst, London, England4 aut |
700 | 1 | a Mortimer, Peteru St George Hosp, Cardiovasc & Cell Sci Inst, London, England4 aut |
700 | 1 | a Jeffery, Steveu St George Hosp, Cardiovasc & Cell Sci Inst, London, England4 aut |
700 | 1 | a Brown, Nigelu St George Hosp, Inst Med & Biomed Educ, London, England4 aut |
700 | 1 | a Mäkinen, Taijau Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)taima352 |
700 | 1 | a Petrova, Tatiana V.u Univ Lausanne, Div Expt Pathol, Ctr Hosp Univ Vaudois, Epalinges, Switzerland;Ludwig Inst Canc Res, Dept Fundamental Oncol, Zurich, Switzerland4 aut |
700 | 1 | a Modarai, Bijanu St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut |
700 | 1 | a Smith, Albertou St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut |
710 | 2 | a St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, Englandb Guys & St Thomas NHS Fdn Trust, Dept Ultrason Angiol, London, England4 org |
773 | 0 | t Journal of Experimental Medicined : Rockefeller University Pressg 214:8, s. 2437-2452q 214:8<2437-2452x 0022-1007x 1540-9538 |
856 | 4 | u https://doi.org/10.1084/jem.20160875y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1250404/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://rupress.org/jem/article-pdf/214/8/2437/1167446/jem_20160875.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-359802 |
856 | 4 8 | u https://doi.org/10.1084/jem.20160875 |
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