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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005773naa a2200601 4500
001oai:DiVA.org:uu-359802
003SwePub
008180924s2017 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3598022 URI
0247 a https://doi.org/10.1084/jem.201608752 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lyons, Oliveru St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut
2451 0a Human venous valve disease caused by mutations in FOXC2 and GJC2
264 c 2017-07-19
264 1b Rockefeller University Press,c 2017
338 a electronic2 rdacarrier
520 a Venous valves (VVs) prevent venous hypertension and ulceration. We report that FOXC2 and GJC2 mutations are associated with reduced VV number and length. In mice, early VV formation is marked by elongation and reorientation ("organization") of Prox1(hi) endothelial cells by postnatal day 0. The expression of the transcription factors Foxc2 and Nfatc1 and the gap junction proteins Gjc2, Gja1, and Gja4 were temporospatially regulated during this process. Foxc2 and Nfatc1 were coexpressed at P0, and combined Foxc2 deletion with calcineurin-Nfat inhibition disrupted early Prox1(hi) endothelial organization, suggesting cooperative Foxc2-Nfatc1 patterning of these events. Genetic deletion of Gjc2, Gja4, or Gja1 also disrupted early VV Prox1(hi) endothelial organization at postnatal day 0, and this likely underlies the VV defects seen in patients with GJC2 mutations. Knockout of Gja4 or Gjc2 resulted in reduced proliferation of Prox1(hi) valve-forming cells. At later stages of blood flow, Foxc2 and calcineurin-Nfat signaling are each required for growth of the valve leaflets, whereas Foxc2 is not required for VV maintenance.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Saha, Prakashu St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut
7001 a Seet, Christopheru St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut
7001 a Kuchta, Adamu Guys & St Thomas NHS Fdn Trust, Dept Ultrason Angiol, London, England4 aut
7001 a Arnold, Andrewu Guys & St Thomas NHS Fdn Trust, Dept Ultrason Angiol, London, England4 aut
7001 a Grover, Stevenu Harvard Med Sch, Boston, MA USA;Beth Israel Deaconess Med Ctr, Div Hemostasis & Thrombosis, Boston, MA 02215 USA4 aut
7001 a Rashbrook, Victoriau St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut
7001 a Sabine, Amelieu Univ Lausanne, Div Expt Pathol, Ctr Hosp Univ Vaudois, Epalinges, Switzerland;Ludwig Inst Canc Res, Dept Fundamental Oncol, Zurich, Switzerland4 aut
7001 a Vizcay-Barrena, Gemau Kings Coll London, Ctr Ultrastruct Imaging, London, England4 aut
7001 a Patel, Ashu St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut
7001 a Ludwinski, Francescau St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut
7001 a Padayachee, Soundrieu Guys & St Thomas NHS Fdn Trust, Dept Ultrason Angiol, London, England4 aut
7001 a Kume, Tsutomuu Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Inst, Evanston, IL USA4 aut
7001 a Kwak, Brenda R.u Univ Geneva, Dept Pathol & Immunol, Geneva, Switzerland4 aut
7001 a Brice, Glenu St George Hosp, South West Thames Reg Genet Serv, London, England4 aut
7001 a Mansour, Saharu St George Hosp, South West Thames Reg Genet Serv, London, England4 aut
7001 a Ostergaard, Piau St George Hosp, Cardiovasc & Cell Sci Inst, London, England4 aut
7001 a Mortimer, Peteru St George Hosp, Cardiovasc & Cell Sci Inst, London, England4 aut
7001 a Jeffery, Steveu St George Hosp, Cardiovasc & Cell Sci Inst, London, England4 aut
7001 a Brown, Nigelu St George Hosp, Inst Med & Biomed Educ, London, England4 aut
7001 a Mäkinen, Taijau Uppsala universitet,Vaskulärbiologi4 aut0 (Swepub:uu)taima352
7001 a Petrova, Tatiana V.u Univ Lausanne, Div Expt Pathol, Ctr Hosp Univ Vaudois, Epalinges, Switzerland;Ludwig Inst Canc Res, Dept Fundamental Oncol, Zurich, Switzerland4 aut
7001 a Modarai, Bijanu St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut
7001 a Smith, Albertou St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, England4 aut
7102 a St Thomas Hosp, Acad Dept Vasc Surg, Cardiovasc Div, BHF Ctr Res Excellence,Kings Coll London, London, Englandb Guys & St Thomas NHS Fdn Trust, Dept Ultrason Angiol, London, England4 org
7730 t Journal of Experimental Medicined : Rockefeller University Pressg 214:8, s. 2437-2452q 214:8<2437-2452x 0022-1007x 1540-9538
8564 u https://doi.org/10.1084/jem.20160875y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1250404/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://rupress.org/jem/article-pdf/214/8/2437/1167446/jem_20160875.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-359802
8564 8u https://doi.org/10.1084/jem.20160875

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