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Exploring causality...
Exploring causality of the association between smoking and Parkinson's disease
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- Gallo, Valentina (författare)
- Queen Mary University,London School of Hygiene and Tropical Medicine,Imperial College London
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- Vineis, Paolo (författare)
- Imperial College London
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- Cancellieri, Mariagrazia (författare)
- University of Campania Luigi Vanvitelli,Queen Mary University,University of Bologna
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- Chiodini, Paolo (författare)
- University of Campania Luigi Vanvitelli
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- Barker, Roger A. (författare)
- University of Cambridge
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- Brayne, Carol (författare)
- University of Cambridge
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- Pearce, Neil (författare)
- London School of Hygiene and Tropical Medicine
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- Vermeulen, Roel (författare)
- University Medical Center Utrecht,Utrecht University
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Bueno-de-Mesquita, Bas (författare)
- University of Malaya,University Medical Center Utrecht,Imperial College London,National Institute for Public Health and the Environment (RIVM)
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- Vanacore, Nicola (författare)
- Italian National Institute of Health (ISS)
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- Forsgren, Lars (författare)
- Umeå universitet,Umeå University,Klinisk neurovetenskap
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- Ramat, Silvia (författare)
- Careggi University Hospital,University of Florence
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Arriola, Larraitz (författare)
- Basque Government,Hospital Universitario Donostia,CIBER Epidemiology and Public Health (CIBERESP)
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- Peterson, Jesper (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Gavrila, Diana (författare)
- Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
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- Sacerdote, Carlotta (författare)
- Human Genetics Foundation (HuGeF),Centre for Cancer Epidemiology and Prevention (CPO Piemonte)
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- Sieri, Sabina (författare)
- Istituto Nazionale dei Tumori
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- Kühn, Tilman (författare)
- German Cancer Research Centre
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- Katzke, Verena A. (författare)
- German Cancer Research Centre
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- van der Schouw, Yvonne T. (författare)
- University Medical Center Utrecht
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- Kyrozis, Andreas (författare)
- National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
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- Masala, Giovanna (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Mattiello, Amalia (författare)
- University of Naples Federico II
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- Perneczky, Robert (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,Imperial College London,Munich Cluster for Systems Neurology,Ludwig-Maximilian University of Munich
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- Middleton, Lefkos (författare)
- Imperial College London
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- Saracci, Rodolfo (författare)
- International Agency for Research on Cancer, World Health Organization
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- Riboli, Elio (författare)
- Imperial College London
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(creator_code:org_t)
- 2018-11-20
- 2019
- Engelska 14 s.
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Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 1464-3685 .- 0300-5771. ; 48:3, s. 912-925
- Relaterad länk:
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http://dx.doi.org/10...
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https://academic.oup...
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: The aim of this paper is to investigate the causality of the inverse association between cigarette smoking and Parkinson's disease (PD). The main suggested alternatives include a delaying effect of smoking, reverse causality or an unmeasured confounding related to a low-risk-taking personality trait. METHODS: A total of 715 incident PD cases were ascertained in a cohort of 220 494 individuals from NeuroEPIC4PD, a prospective European population-based cohort study including 13 centres in eight countries. Smoking habits were recorded at recruitment. We analysed smoking status, duration, and intensity and exposure to passive smoking in relation to PD onset. RESULTS: Former smokers had a 20% decreased risk and current smokers a halved risk of developing PD compared with never smokers. Strong dose-response relationships with smoking intensity and duration were found. Hazard ratios (HRs) for smoking <20 years were 0.84 [95% confidence interval (CI) 0.67-1.07], 20-29 years 0.73 (95% CI 0.56-0.96) and >30 years 0.54 (95% CI 0.43-0.36) compared with never smokers. The proportional hazard assumption was verified, showing no change of risk over time, arguing against a delaying effect. Reverse causality was disproved by the consistency of dose-response relationships among former and current smokers. The inverse association between passive smoking and PD, HR 0.70 (95% CI 0.49-0.99) ruled out the effect of unmeasured confounding. CONCLUSIONS: These results are highly suggestive of a true causal link between smoking and PD, although it is not clear which is the chemical compound in cigarette smoking responsible for the biological effect.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- causal inference
- cohort study
- EPIC
- NeuroEPIC4PD
- Parkinson’s disease
- passive smoking
- smoking
- smoking patterns
- Neurology
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gallo, Valentina
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Vineis, Paolo
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Cancellieri, Mar ...
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Chiodini, Paolo
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Barker, Roger A.
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Brayne, Carol
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visa fler...
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Pearce, Neil
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Vermeulen, Roel
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Vanacore, Nicola
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Forsgren, Lars
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Ramat, Silvia
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Ardanaz, Eva
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Arriola, Larrait ...
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Peterson, Jesper
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Hansson, Oskar
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Gavrila, Diana
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Sacerdote, Carlo ...
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Sieri, Sabina
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Kühn, Tilman
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Katzke, Verena A ...
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van der Schouw, ...
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Kyrozis, Andreas
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Masala, Giovanna
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Mattiello, Amali ...
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Perneczky, Rober ...
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Middleton, Lefko ...
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Saracci, Rodolfo
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Riboli, Elio
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- Av lärosätet
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Lunds universitet
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Umeå universitet