The Combined Value of Faecal Haemoglobin andCalprotectin in Diagnosis of Colorectal Cancer inSymptomatic Patients Referred to Colonoscopy

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Fältnamn	Indikatorer	Metadata
000		03964naa a2200397 4500
001		oai:DiVA.org:umu-171108
003		SwePub
008		200526s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1711082 URI
024	7	a https://doi.org/10.33552/AJGH.2019.01.0005142 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a vet2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Eklöf, Vincy,d 1984-u Umeå universitet,Patologi4 aut0 (Swepub:umu)viyekf03
245	1 0	a The Combined Value of Faecal Haemoglobin andCalprotectin in Diagnosis of Colorectal Cancer inSymptomatic Patients Referred to Colonoscopy
264	1	a San Fransisco :b Iris Publishers,c 2019
338		a electronic2 rdacarrier
520		a Aim: To investigate the diagnostic value of a combined analyses of faecal immunological haemoglobin (FIT) and faecal calprotectin (FC) in detection of colorectal cancer (CRC).Methods: Out-patients (n=1440) referred to the endoscopy unit were analysed for FIT and FC in stool samples collected before the colonoscopy bowel preparation. The samples were collected from one defecation by the patients at home. Patients with IBD were excluded leaving stool samples from 1133 patients for further analyses. FIT was analysed using the immunological Analyse F.O.B Test and FC was analysed using the CALPRO® Calprotectin Elisa Test. Sensitivity and specificity to detect CRC was calculated for the individual tests, as well as for combined FIT/FC tests.Results: Out of the included patients, 38 were diagnosed with CRC, 9 with high grade dysplasia (HGD), and 133 with low grade dysplasia (LGD). FIT was analysed in 673 (59.4%), FC in 1021 (90.1%) and both FIT and FC in 561 (49.5%) patients. A ROC curve analysis showed that the most accurate cut-off level for FC in detecting CRC in our study was 105.5 µg/g. The sensitivity for CRC when using FIT, FC (cut-off > 100 µg/g) and the combination of FIT and FC (at least one positive test) was 65.5%, 74.1% and 94.4%, respectively. The corresponding specificity was 84.8%, 74.9% and 68.3%, respectively.Conclusion: Combined analyses of FIT and FC improved sensitivity for detection of CRC. Further studies in larger cohorts are required to find the optimal cut-off levels for different combinations of tests.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a Colorectal cancer; F-Calprotectin; F-Hb: Faecal markers; Screening markers
700	1	a Lundgren, Davidu Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)dadlun96
700	1	a Karling, Pontusu Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)peakag84
700	1	a Wikberg, Maria L.u Umeå universitet,Patologi4 aut0 (Swepub:umu)mahe0061
700	1	a Edin, Sofiau Umeå universitet,Patologi4 aut0 (Swepub:umu)soed0001
700	1	a Löfgren Burström, Annau Umeå universitet,Patologi4 aut0 (Swepub:umu)anlo0002
700	1	a Rutegård, Jörgen,d 1948-u Umeå universitet,Kirurgi4 aut0 (Swepub:umu)jaru0001
700	1	a Palmqvist, Richardu Umeå universitet,Patologi4 aut0 (Swepub:umu)ripa0001
710	2	a Umeå universitetb Patologi4 org
773	0	t Academic Journal of Gastroenterology & Hepatology (AJGH)d San Fransisco : Iris Publishersg 1:3, s. 1-7q 1:3<1-7
856	4	u https://irispublishers.com/ajgh/abstract/the-combined-value-of-faecal-haemoglobin-and-calprotectin-in-diagnosis-of-colorectal-cancer.ID.000514.phpy URL
856	4	u https://umu.diva-portal.org/smash/get/diva2:1432316/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-171108
856	4 8	u https://doi.org/10.33552/AJGH.2019.01.000514

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Av författaren/redakt...: Eklöf, Vincy, 19 ...; Lundgren, David; Karling, Pontus; Wikberg, Maria L ...; Edin, Sofia; Löfgren Burström ...; visa fler...; Rutegård, Jörgen ...; Palmqvist, Richa ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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Av lärosätet: Umeå universitet

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