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  • Johansson, Karl-AxelGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences (author)

The quality assurance process for the ARTSCAN head and neck study - a practical interactive approach for QA in 3DCRT and IMRT.

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Elsevier BV,2008

Numbers

  • LIBRIS-ID:oai:gup.ub.gu.se/100360
  • https://gup.ub.gu.se/publication/100360URI
  • https://doi.org/10.1016/j.radonc.2007.12.005DOI
  • https://lup.lub.lu.se/record/1187293URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-9670URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:117232351URI

Supplementary language notes

  • Language:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • AIM: This paper describes the quality assurance (QA) work performed in the Swedish multicenter ARTSCAN (Accelerated RadioTherapy of Squamous cell CArcinomas in the head and Neck) trial to guarantee high quality in a multicenter study which involved modern radiotherapy such as 3DCRT or IMRT. MATERIALS AND METHODS: The study was closed in June 2006 with 750 randomised patients. Radiation therapy-related data for every patient were sent by each participating centre to the QA office where all trial data were reviewed, analysed and stored. In case of any deviation from the protocol, an interactive process was started between the QA office and the local responsible clinician and/or physicist to increase the compliance to the protocol for future randomised patients. Meetings and workshops were held on a regular basis for discussions on various trial-related issues and for the QA office to report on updated results. RESULTS AND DISCUSSION: This review covers the 734 patients out of a total of 750 who had entered the study. Deviations early in the study were corrected so that the overall compliance to the protocol was very high. There were only negligible variations in doses and dose distributions to target volumes for each specific site and stage. The quality of the treatments was high. Furthermore, an extensive database of treatment parameters was accumulated for future dose-volume vs. endpoint evaluations. CONCLUSIONS: This comprehensive QA programme increased the probability to draw firm conclusions from our study and may serve as a concept for QA work in future radiotherapy trials where comparatively small effects are searched for in a heterogeneous tumour population.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Nilsson, PerLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)rafy-per (author)
  • Zackrisson, Björn (author)
  • Ohlson, BirgittaGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences (author)
  • Kjellén, ElisabethLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ekj (author)
  • Mercke, Claes,1941Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xmercl (author)
  • Alvarez-Fonseca, Mauricio (author)
  • Billström, Anette (author)
  • Björk-Eriksson, Thomas,1960Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xbjoth (author)
  • Björ, Ove (author)
  • Ekberg, Lars (author)
  • Friesland, SigneKarolinska Institutet (author)
  • Karlsson, MagnusUmeå universitet,Radiofysik(Swepub:umu)maskan95 (author)
  • Lagerlund, Magnus (author)
  • Lundkvist, LenaUmeå universitet,Onkologi(Swepub:umu)lelu0017 (author)
  • Löfroth, Per-Olov (author)
  • Löfvander-Thapper, KerstinLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)radf-klo (author)
  • Nilsson, Alla (author)
  • Nyman, Jan,1956Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences(Swepub:gu)xnymja (author)
  • Persson, Essie (author)
  • Reizenstein, Johan (author)
  • Rosenbrand, Hans-Olov (author)
  • Wiklund, FredrikUmeå universitet,Onkologi (author)
  • Wittgren, Lena (author)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper (creator_code:org_t)

Related titles

  • In:Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology: Elsevier BV87:2, s. 290-90167-81401879-0887

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