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Cross-ancestry geno...
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
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- Byun, Jinyoung (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States
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- Han, Younghun (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States
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- Li, Yafang (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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visa fler...
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- Xia, Jun (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States
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- Long, Erping (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Choi, Jiyeon (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Xiao, Xiangjun (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
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- Zhu, Meng (författare)
- Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China
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- Zhou, Wen (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
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- Sun, Ryan (författare)
- Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, TX, Houston, United States
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- Bossé, Yohan (författare)
- Institut universitaire de cardiologie et de pneumologie de Québec – Université Laval, Department of Molecular Medicine, Laval University, QC, Quebec City, Canada
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- Song, Zhuoyi (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States
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- Schwartz, Ann (författare)
- Department of Oncology, Wayne State University School of Medicine, MI, Detroit, United States; Karmanos Cancer Institute, MI, Detroit, United States
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- Lusk, Christine (författare)
- Department of Oncology, Wayne State University School of Medicine, MI, Detroit, United States; Karmanos Cancer Institute, MI, Detroit, United States
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- Rafnar, Thorunn (författare)
- deCODE genetics/Amgen Sturlugata 8, Reykjavik, Iceland
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- Stefansson, Kari (författare)
- deCODE genetics/Amgen Sturlugata 8, Reykjavik, Iceland
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- Zhang, Tongwu (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Zhao, Wei (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Pettit, Rowland W. (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
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- Liu, Yanhong (författare)
- Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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- Li, Xihao (författare)
- Department of Biostatistics, Harvard TH Chan School of Public Health, MA, Boston, United States
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- Zhou, Hufeng (författare)
- Department of Biostatistics, Harvard TH Chan School of Public Health, MA, Boston, United States
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- Walsh, Kyle M. (författare)
- Duke Cancer Institute, Duke University Medical Center, NC, Durham, United States
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- Gorlov, Ivan (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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- Gorlova, Olga (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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- Zhu, Dakai (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States
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- Rosenberg, Susan M. (författare)
- Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States; Department of Molecular and Human Genetics, Baylor College of Medicine, TX, Houston, United States
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- Pinney, Susan (författare)
- University of Cincinnati College of Medicine, OH, Cincinnati, United States
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- Bailey-Wilson, Joan E. (författare)
- National Human Genome Research Institute, NIH, MD, Baltimore, United States
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- Mandal, Diptasri (författare)
- Louisiana State University Health Sciences Center, LA, New Orleans, United States
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- de Andrade, Mariza (författare)
- Mayo Clinic, College of Medicine, MN, Rochester, United States
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- Gaba, Colette (författare)
- The University of Toledo College of Medicine and Life Sciences, University of Toledo, OH, Toledo, United States
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- Willey, James C. (författare)
- The University of Toledo College of Medicine and Life Sciences, University of Toledo, OH, Toledo, United States
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- You, Ming (författare)
- Center for Cancer Prevention, Houston Methodist Research Institute, TX, Houston, United States
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- Anderson, Marshall (författare)
- University of Cincinnati College of Medicine, OH, Cincinnati, United States
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- Wiencke, John K. (författare)
- Department of Neurological Surgery, University of California, San Francisco, CA, San Francisco, United States
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- Albanes, Demetrius (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Lam, Stephan (författare)
- Department of Integrative Oncology, BC Cancer, BC, Vancouver, Canada
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- Tardon, Adonina (författare)
- Public Health Department, University of Oviedo, ISPA and CIBERESP, Asturias, Spain
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- Chen, Chu (författare)
- Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Baylor College of Medicine
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- Goodman, Gary (författare)
- Swedish Cancer Institute, WA, Seattle, United States
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- Bojeson, Stig (författare)
- Department of Clinical Biochemistry, Herlev Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Brenner, Hermann (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Landi, Maria Teresa (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Chanock, Stephen J. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Johansson, Mattias (författare)
- Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Muley, Thomas (författare)
- Division of Cancer Epigenomics, DKFZ – German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany
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- Risch, Angela (författare)
- Division of Cancer Epigenomics, DKFZ – German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), Heidelberg, Germany; Department of Biosciences and Medical Biology, Allergy-Cancer-BioNano Research Centre, University of Salzburg, Salzburg, Austria; Cancer Cluster Salzburg, Salzburg, Austria
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- Wichmann, H.-Erich (författare)
- Institute of Epidemiology, Helmholtz Center, Munich, Germany
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- Bickeböller, Heike (författare)
- Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany
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- Christiani, David C. (författare)
- Department of Epidemiology, Harvard T.H.Chan School of Public Health, MA, Boston, United States
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- Rennert, Gad (författare)
- Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
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- Arnold, Susanne (författare)
- University of Kentucky, Markey Cancer Center, KY, Lexington, United States
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- Field, John K. (författare)
- Roy Castle Lung Cancer Research Programme, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom
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- Shete, Sanjay (författare)
- Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center, TX, Houston, United States; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, TX, Houston, United States
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- Le Marchand, Loic (författare)
- Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States
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- Melander, O. (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Brunnstrom, H. (författare)
- Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Liu, Geoffrey (författare)
- University Health Network- The Princess Margaret Cancer Centre, Ontario, Toronto, Canada
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- Andrew, Angeline S. (författare)
- Departments of Epidemiology and Community and Family Medicine, Dartmouth College, NH, Hanover, United States
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- Kiemeney, Lambertus A. (författare)
- Radboud University Medical Center, Nijmegen, Netherlands
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- Shen, Hongbing (författare)
- Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China
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- Zienolddiny, Shanbeh (författare)
- National Institute of Occupational Health, Oslo, Norway
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- Grankvist, Kjell (författare)
- Umeå universitet,Klinisk kemi
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- Johansson, Mikael (författare)
- Umeå universitet,Onkologi
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- Caporaso, Neil (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Cox, Angela (författare)
- Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom
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- Hong, Yun-Chul (författare)
- Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea
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- Yuan, Jian-Min (författare)
- UPMC Hillman Cancer Center and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
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- Lazarus, Philip (författare)
- Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States
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- Schabath, Matthew B. (författare)
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States
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- Aldrich, Melinda C. (författare)
- Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, TN, Nashville, United States
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- Patel, Alpa (författare)
- American Cancer Society, GA, Atlanta, United States
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- Lan, Qing (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Rothman, Nathaniel (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Taylor, Fiona (författare)
- Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom
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- Kachuri, Linda (författare)
- Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, San Francisco, United States
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- Witte, John S. (författare)
- Department of Epidemiology and Population Health, Stanford University, CA, Stanford, United States
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- Sakoda, Lori C. (författare)
- Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
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- Spitz, Margaret (författare)
- Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States
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- Brennan, Paul (författare)
- Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Lin, Xihong (författare)
- Department of Biostatistics, Harvard TH Chan School of Public Health, MA, Boston, United States
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- McKay, James (författare)
- Section of Genetics, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Hung, Rayjean J. (författare)
- Lunenfeld-Tanenbaum Research Institute, Sinai Health System, ON, Toronto, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, ON, Toronto, Canada
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- Amos, Christopher I. (författare)
- Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, TX, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, TX, Houston, United States
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(creator_code:org_t)
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et al
- 2022-08-01
- 2022
- Engelska.
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Ingår i: Nature Genetics. - : Nature Research. - 1061-4036 .- 1546-1718. ; 54:8, s. 1167-1177
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- DNA binding protein
- FUBP1 protein, human
- RNA binding protein
- genetic predisposition
- genetics
- genome-wide association study
- human
- lung tumor
- meta analysis
- quantitative trait locus
- single nucleotide polymorphism
- DNA-Binding Proteins
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Lung Neoplasms
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- RNA-Binding Proteins
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Byun, Jinyoung
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Han, Younghun
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Li, Yafang
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Xia, Jun
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Long, Erping
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Choi, Jiyeon
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visa fler...
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Xiao, Xiangjun
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Zhu, Meng
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Zhou, Wen
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Sun, Ryan
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Bossé, Yohan
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Song, Zhuoyi
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Schwartz, Ann
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Lusk, Christine
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Rafnar, Thorunn
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Stefansson, Kari
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Zhang, Tongwu
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Zhao, Wei
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Pettit, Rowland ...
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Liu, Yanhong
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Li, Xihao
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Zhou, Hufeng
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Walsh, Kyle M.
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Gorlov, Ivan
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Gorlova, Olga
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Zhu, Dakai
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Rosenberg, Susan ...
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Pinney, Susan
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Bailey-Wilson, J ...
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Mandal, Diptasri
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de Andrade, Mari ...
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Gaba, Colette
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Willey, James C.
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You, Ming
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Anderson, Marsha ...
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Wiencke, John K.
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Albanes, Demetri ...
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Lam, Stephan
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Tardon, Adonina
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Chen, Chu
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Goodman, Gary
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Bojeson, Stig
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Brenner, Hermann
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Landi, Maria Ter ...
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Chanock, Stephen ...
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Johansson, Matti ...
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Muley, Thomas
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Risch, Angela
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Wichmann, H.-Eri ...
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Bickeböller, Hei ...
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Christiani, Davi ...
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Rennert, Gad
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Arnold, Susanne
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Field, John K.
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Shete, Sanjay
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Le Marchand, Loi ...
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Melander, O.
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Brunnstrom, H.
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Liu, Geoffrey
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Andrew, Angeline ...
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Kiemeney, Lamber ...
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Shen, Hongbing
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Zienolddiny, Sha ...
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Grankvist, Kjell
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Johansson, Mikae ...
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Caporaso, Neil
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Cox, Angela
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Hong, Yun-Chul
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Yuan, Jian-Min
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Lazarus, Philip
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Schabath, Matthe ...
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Aldrich, Melinda ...
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Patel, Alpa
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Lan, Qing
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Rothman, Nathani ...
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Taylor, Fiona
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Kachuri, Linda
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Witte, John S.
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Sakoda, Lori C.
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Spitz, Margaret
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Brennan, Paul
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Lin, Xihong
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McKay, James
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Hung, Rayjean J.
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Amos, Christophe ...
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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Nature Genetics
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