WFRF:(Le Roux Carel W.)
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Integrated insights into the role of alpha-melanocyte stimulatory hormone in the control of food intake and glycaemia
- Al-Najim, W. (author)
-
- le Roux, Carel W (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education
-
- Docherty, Neil G. (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för gastrokirurgisk forskning och utbildning,Institute of Clinical Sciences, Department of Gastrosurgical Research and Education
- (creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
- In: Peptides. - : Elsevier BV. - 0196-9781. ; 100, s. 243-248
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Identifying peptide hormones with multipotent actions on both weight and glycaemia can have a significant impact on therapeutic options in the treatment of obesity and diabetes. This has been exemplified by recent advances involving pharmacological exploitation of glucagon-like peptide 1 biology. Herein, we summarise evidence supporting the potential candidacy in this light of alpha-melanocyte stimulatory hormone, an endogenous peptide hormone and a breakdown product of the neuropeptide pro-opiomelanocortin. We reference its well described central actions in the control of food intake and moreover highlight new data pointing to an important role for this peptide hormone in the periphery, in relation to glycaemic control.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Diabetes
- Obesity
- Hormones
- Pituitary
- Skeletal muscle
- Hypothalamus
- agouti-related protein
- human melanocortin-4 receptor
- tumor-necrosis-factor
- insulin-resistance
- glucose-homeostasis
- signal-transduction
- biological-activity
- plasma-levels
- agonist mtii
- weight-loss
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Pharmacology & Pharmacy
- iences
- v361
- p1265
- ar ra
- 1995
- proceedings of the national academy of sciences of the united states of
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- ref (subject category)
- art (subject category)
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- University of Gothenburg
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