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Sökning: WFRF:(Lemnge Martha) > (2012) > Reliability of rapi...

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FältnamnIndikatorerMetadata
00004774naa a2200613 4500
001oai:DiVA.org:su-81805
003SwePub
008121101s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-818052 URI
0247 a https://doi.org/10.1186/1475-2875-11-2112 DOI
040 a (SwePub)su
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Minja, Daniel T. R.4 aut
2451 0a Reliability of rapid diagnostic tests in diagnosing pregnancy associated malaria in North Eastern Tanzania
264 c 2012-06-21
264 1b Springer Science and Business Media LLC,c 2012
338 a print2 rdacarrier
500 a AuthorCount:15;
520 a Background: Accurate diagnosis and prompt treatment of pregnancy-associated malaria (PAM) are key aspects in averting adverse pregnancy outcomes. Microscopy is the gold standard in malaria diagnosis, but it has limited detection and availability. When used appropriately, rapid diagnostic tests (RDTs) could be an ideal diagnostic complement to microscopy, due to their ease of use and adequate sensitivity in detecting even sub-microscopic infections. Polymerase chain reaction (PCR) is even more sensitive, but it is mainly used for research purposes. The accuracy and reliability of RDTs in diagnosing PAM was evaluated using microscopy and PCR. Methods: A cohort of pregnant women in north-eastern Tanzania was followed throughout pregnancy for detection of plasmodial infection using venous and placental blood samples evaluated by histidine rich protein 2 (HRP-2) and parasite lactate dehydrogenase (pLDH) based RDTs (Parascreen (TM)) or HRP-2 only (Paracheck Pf (R) and ParaHIT (R) f), microscopy and nested Plasmodium species diagnostic PCR. Results: From a cohort of 924 pregnant women who completed the follow up, complete RDT and microscopy data was available for 5,555 blood samples and of these 442 samples were analysed by PCR. Of the 5,555 blood samples, 49 ((proportion and 95% confidence interval) 0.9% [0.7 - 1.1]) samples were positive by microscopy and 91 (1.6% [1.3-2.0]) by RDT. Forty-six (50.5% [40.5 - 60.6]) and 45 (49.5% [39.4 - 59.5]) of the RDT positive samples were positive and negative by microscopy, respectively, whereas nineteen (42.2% [29.0 - 56.7]) of the microscopy negative, but RDT positive, samples were positive by PCR. Three (0.05% [0.02 - 0.2]) samples were positive by microscopy but negative by RDT. 351 of the 5,461 samples negative by both RDT and microscopy were tested by PCR and found negative. There was no statistically significant difference between the performances of the different RDTs. Conclusions: Microscopy underestimated the real burden of malaria during pregnancy and RDTs performed better than microscopy in diagnosing PAM. In areas where intermittent preventive treatment during pregnancy may be abandoned due to low and decreasing malaria risk and instead replaced with active case management, screening with RDT is likely to identify most infections in pregnant women and out-performs microscopy as a diagnostic tool.
650 7a NATURVETENSKAPx Biologix Immunologi0 (SwePub)106052 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Immunology0 (SwePub)106052 hsv//eng
653 a Rapid diagnostic tests (RDTs)
653 a Reliability
653 a Sensitivity
653 a Plasmodium falciparum
653 a Pregnancy-Associated Malaria (PAM)
653 a Microscopy
653 a Polymerase chain reaction (PCR)
653 a Sub-microscopic infections
653 a Pregnancy outcomes
653 a Tanzania
7001 a Schmiegelow, Christentze4 aut
7001 a Oesterholt, Mayke4 aut
7001 a Magistrado, Pamela A.4 aut
7001 a Boström, Stephanieu Stockholms universitet,Avdelningen för immunologi4 aut0 (Swepub:su)stbo7601
7001 a John, Davis4 aut
7001 a Pehrson, Caroline4 aut
7001 a Andersen, Daniel4 aut
7001 a Deloron, Philippe4 aut
7001 a Salanti, Ali4 aut
7001 a Lemnge, Martha4 aut
7001 a Luty, Adrian J. F.4 aut
7001 a Alifrangis, Michael4 aut
7001 a Theander, Thor4 aut
7001 a Lusingu, John P. A.4 aut
7102 a Stockholms universitetb Avdelningen för immunologi4 org
7730 t Malaria Journald : Springer Science and Business Media LLCg 11, s. 211-q 11<211-x 1475-2875
8564 u https://doi.org/10.1186/1475-2875-11-211y Fulltext
8564 u https://malariajournal.biomedcentral.com/track/pdf/10.1186/1475-2875-11-211
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-81805
8564 8u https://doi.org/10.1186/1475-2875-11-211

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