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Biliverdin Reductas...
Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis
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- Chemaly, Melody (author)
- Karolinska Inst, Dept Mol Med & Surg, S-17177 Stockholm, Sweden.
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- Marlevi, David (author)
- Karolinska Institutet
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- Iglesias, Maria Jesus (author)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik
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- Lengquist, Mariette (author)
- Karolinska Institutet
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- Kronqvist, Malin (author)
- Karolinska Institutet
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- Bos, Daniel (author)
- Erasmus MC, Univ Med Ctr Rotterdam, Dept Radiol & Nucl Med, NL-3015 GD Rotterdam, Netherlands.;Erasmus MC, Univ Med Ctr, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands.
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- van Dam-Nolen, Dianne H. K. (author)
- Erasmus MC, Univ Med Ctr Rotterdam, Dept Radiol & Nucl Med, NL-3015 GD Rotterdam, Netherlands.
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- van der Kolk, Anja (author)
- Radboud Univ Nijmegen, Dept Med Imaging, Med Ctr, NL-6500 HB Nijmegen, Netherlands.;Univ Med Ctr Utrecht, Dept Radiol, NL-3508 GA Utrecht, Netherlands.
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- Hendrikse, Jeroen (author)
- Univ Med Ctr Utrecht, Dept Radiol, NL-3508 GA Utrecht, Netherlands.
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- Kassem, Mohamed (author)
- Maastricht Univ, CARIM Sch Cardiovasc Dis, Dept Radiol & Nucl Med, Med Ctr, NL-6229 ER Maastricht, Netherlands.
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- Matic, Ljubica (author)
- Karolinska Institutet
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- Odeberg, Jacob, Professor, 1963- (author)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik,Karolinska Univ Hosp, Dept Hematol, S-14152 Huddinge, Stockholm, Sweden.;UiT The Arctic Univ Norway, Dept Clin Med, N-9019 Tromso, Norway.
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- de Vries, Margreet R. (author)
- Leiden Univ, Dept Surg, Einthoven Lab, Med Ctr, NL-2333 ZA Leiden, Netherlands.
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- Kooi, M. Eline (author)
- Maastricht Univ, CARIM Sch Cardiovasc Dis, Dept Radiol & Nucl Med, Med Ctr, NL-6229 ER Maastricht, Netherlands.
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- Hedin, Ulf (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Mol Med & Surg, S-17177 Stockholm, Sweden (creator_code:org_t)
- MDPI AG, 2023
- 2023
- English.
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In: Biomolecules. - : MDPI AG. - 2218-273X. ; 13:6
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
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- Background: Intraplaque hemorrhage (IPH) is a hallmark of atherosclerotic plaque instability. Biliverdin reductase B (BLVRB) is enriched in plasma and plaques from patients with symptomatic carotid atherosclerosis and functionally associated with IPH. Objective: We explored the biomarker potential of plasma BLVRB through (1) its correlation with IPH in carotid plaques assessed by magnetic resonance imaging (MRI), and with recurrent ischemic stroke, and (2) its use for monitoring pharmacotherapy targeting IPH in a preclinical setting. Methods: Plasma BLVRB levels were measured in patients with symptomatic carotid atherosclerosis from the PARISK study (n = 177, 5 year follow-up) with and without IPH as indicated by MRI. Plasma BLVRB levels were also measured in a mouse vein graft model of IPH at baseline and following antiangiogenic therapy targeting vascular endothelial growth factor receptor 2 (VEGFR-2). Results: Plasma BLVRB levels were significantly higher in patients with IPH (737.32 & PLUSMN; 693.21 vs. 520.94 & PLUSMN; 499.43 mean fluorescent intensity (MFI), p = 0.033), but had no association with baseline clinical and biological parameters. Plasma BLVRB levels were also significantly higher in patients who developed recurrent ischemic stroke (1099.34 & PLUSMN; 928.49 vs. 582.07 & PLUSMN; 545.34 MFI, HR = 1.600, CI [1.092-2.344]; p = 0.016). Plasma BLVRB levels were significantly reduced following prevention of IPH by anti-VEGFR-2 therapy in mouse vein grafts (1189 & PLUSMN; 258.73 vs. 1752 & PLUSMN; 366.84 MFI; p = 0.004). Conclusions: Plasma BLVRB was associated with IPH and increased risk of recurrent ischemic stroke in patients with symptomatic low- to moderate-grade carotid stenosis, indicating the capacity to monitor the efficacy of IPH-preventive pharmacotherapy in an animal model. Together, these results suggest the utility of plasma BLVRB as a biomarker for atherosclerotic plaque instability.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- intraplaque hemorrhage
- biliverdin reductase B
- ischemic stroke
- vulnerable atherosclerotic plaque
- antiangiogenic therapy
- magnetic resonance imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chemaly, Melody
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Marlevi, David
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Iglesias, Maria ...
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Lengquist, Marie ...
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Kronqvist, Malin
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Bos, Daniel
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van Dam-Nolen, D ...
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van der Kolk, An ...
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Hendrikse, Jeroe ...
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Kassem, Mohamed
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Matic, Ljubica
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Odeberg, Jacob, ...
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de Vries, Margre ...
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Kooi, M. Eline
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Hedin, Ulf
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Biomolecules
- By the university
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Royal Institute of Technology
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Karolinska Institutet