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WFRF:(Levi Marcel)
 

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FältnamnIndikatorerMetadata
00008258naa a2200793 4500
001oai:DiVA.org:oru-74040
003SwePub
008190506s2017 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:eb91f57d-3c7e-4881-8ed8-cdb9505f781a
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-740402 URI
0247 a https://doi.org/10.1186/s13195-017-0328-92 DOI
0247 a https://lup.lub.lu.se/record/eb91f57d-3c7e-4881-8ed8-cdb9505f781a2 URI
040 a (SwePub)orud (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bos, Isabelleu Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands4 aut
2451 0a Cerebrovascular and amyloid pathology in predementia stages :b the relationship with neurodegeneration and cognitive decline
264 c 2017-12-29
264 1b BioMed Central,c 2017
338 a print2 rdacarrier
500 a Funding agencies:European Medical Information Framework Alzheimer’s disease (EMIF-AD) project - Innovative Medicines Initiative under EMIFEuropean Federation of Pharmaceutical Industries and Associations (EFPIA)Center for Translational Molecular MedicineEuropean Commission, 5th framework program
520 a BACKGROUND: Cerebrovascular disease (CVD) and amyloid-β (Aβ) often coexist, but their influence on neurodegeneration and cognition in predementia stages remains unclear. We investigated the association between CVD and Aβ on neurodegenerative markers and cognition in patients without dementia.METHODS: We included 271 memory clinic patients with subjective or objective cognitive deficits but without dementia from the BioBank Alzheimer Center Limburg cohort (n = 99) and the LeARN (n = 50) and DESCRIPA (n = 122) multicenter studies. CSF Aβ1-42 and white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) scans were used as measures of Aβ and CVD, respectively. Individuals were classified into four groups based on the presence (+) or absence (-) of Aβ and WMH. We investigated differences in phosphorylated tau, total tau (t-tau), and medial temporal lobe atrophy (MTA) between groups using general linear models. We examined cognitive decline and progression to dementia using linear mixed models and Cox proportional hazards models. All analyses were adjusted for study and demographics.RESULTS: MTA and t-tau were elevated in the Aβ - WMH+, Aβ + WMH-, and Aβ + WMH+ groups. MTA was most severe in the Aβ + WMH+ group compared with the groups with a single pathology. Both WMH and Aβ were associated with cognitive decline, but having both pathologies simultaneously was not associated with faster decline.CONCLUSIONS: In the present study, we found an additive association of Aβ and CVD pathology with baseline MTA but not with cognitive decline. Because our findings may have implications for diagnosis and prognosis of memory clinic patients and for future scientific research, they should be validated in a larger sample with longer follow-up.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
653 a Alzheimer’s disease
653 a Amyloid
653 a Cerebrospinal fluid
653 a Cerebrovascular disease
653 a Cognition
653 a MRI
653 a Medial temporal lobe atrophy
653 a Neurodegeneration
653 a Tau
653 a Alzheimer's disease
653 a Amyloid
653 a Cerebrospinal fluid
653 a Cerebrovascular disease
653 a Cognition
653 a Medial temporal lobe atrophy
653 a MRI
653 a Neurodegeneration
653 a Tau
7001 a Verhey, Frans R.u Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands4 aut
7001 a Ramakers, Inez H. G. B.u Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands,Pitié-Salpêtrière University Hospital4 aut
7001 a Jacobs, Heidi I. L.u Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands4 aut
7001 a Soininen, Hilkkau Institute of Clinical Medicine, Neurology, University of Eastern Finland, Kuopio, Finland; Neurocenter & Department of Neurology, Kuopio University Hospital, Kuopio, Finland4 aut
7001 a Freund-Levi, Yvonne,d 1956-u Department of Neurobiology, Caring Sciences and Society (NVS), Karolinska University Hospital Huddinge, Stockholm, Sweden4 aut0 (Swepub:oru)yfi
7001 a Hampel, Haraldu AXA Research Fund and UPMC Chair, Sorbonne Universités, Université Pierre et Marie Curie (UPMC), Paris, France; Institut du cerveau et de la moelle (ICM), Hôpital Pitié-Salpêtrière, Paris, France4 aut
7001 a Tsolaki, Magdau Aristotle University of Thessaloniki, Memory and Dementia Center, 3rd Department of Neurology, “G Papanicolau” General Hospital, Thessaloniki, Greece4 aut
7001 a Wallin, Åsa K.u Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)med-was
7001 a van Buchem, Mark A.u Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands4 aut
7001 a Oleksik, Aniau Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands4 aut
7001 a Verbeek, Marcel M.u Departments of Neurology and Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Center, Radboud University Medical Center, Nijmegen, The Netherlands4 aut
7001 a Olde Rikkert, Marcelu Radboudumc Alzheimer Centre, Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands4 aut
7001 a van der Flier, Wiesje M.u Department of Neurology, Alzheimer Centre, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
7001 a Scheltens, Philipu Department of Neurology, Alzheimer Centre, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
7001 a Aalten, Paulineu Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands4 aut
7001 a Visser, Pieter Jelleu Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands; Department of Neurology, Alzheimer Centre, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut
7001 a Vos, Stephanie J. B.u Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlands4 aut
7102 a Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, The Netherlandsb Pitié-Salpêtrière University Hospital4 org
7730 t Alzheimer's Research & Therapyd : BioMed Centralg 9:1q 9:1x 1758-9193
8564 u https://doi.org/10.1186/s13195-017-0328-9y Fulltext
8564 u https://doi.org/10.1186/s13195-017-0328-9
8564 u http://dx.doi.org/10.1186/s13195-017-0328-9x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74040
8564 8u https://doi.org/10.1186/s13195-017-0328-9
8564 8u https://lup.lub.lu.se/record/eb91f57d-3c7e-4881-8ed8-cdb9505f781a

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