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Sökning: WFRF:(Li Wen Jun) > (2007-2009) > Microsatellite inst...

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FältnamnIndikatorerMetadata
00003382naa a2200421 4500
001oai:DiVA.org:liu-40458
003SwePub
008091010s2007 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-404582 URI
0247 a https://doi.org/10.1159/0001111072 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Meng, Wen-Jian4 aut
2451 0a Microsatellite instability did not predict individual survival in sporadic stage II and III rectal cancer patients
264 c 2007-11-14
264 1b S. Karger AG,c 2007
338 a print2 rdacarrier
520 a Objectives: Tumors with high-frequency microsatellite instability (MSI-H) have unique biological behavior and the predictive role of microsatellite instability (MSI) status on survival of colorectal cancer is still debated. The prognostic significance of MSI status in sporadic stage II and III rectal cancer patients needs to be more precisely defined. So we investigated the relationship between MSI status and clinicopathological features and prognosis in these patients. Methods: DNAs from fresh-frozen paired samples of tumors and corresponding normal tissue from 128 stage II and III rectal cancer patients were analyzed for MSI by PCR amplification using markers recommended by a National Cancer Institute workshop on MSI. To assess prognostic significance, Cox proportional hazards modeling was used. Results: Twelve (9.3%) tumors in our study were MSI-H, 28 (21.9%) were low-frequency MSI (MSI-L) and 88 (68.8%) were microsatellite stable (MSS). Most of the MSI-H tumors compared with MSI-L and MSS tumors were found in female patients (p = 0.031), had mucinous histology (p = 0.023), high grade of differentiation (p = 0.002) and high level of preoperative serum carcinoembryonic antigen (p = 0.005). Rectal cancer patients with MSI-H did not show a better clinical outcome than those with MSI-L/MSS, neither in all cases (p = 0.986) nor in stage II and stage III disease analyzed separately (p = 0.705 and p = 0.664, respectively). Conclusions: Data provided here demonstrated there was high incidence of MSI-H and MSI was not a prognostic factor in sporadic stage II and III rectal cancers from the Chinese Han population included in this study. Tumor stage is more suitable than MSI status for prediction of individual survival in sporadic stage II and III rectal cancer patients. Copyright © 2007 S. Karger AG.
653 a MEDICINE
653 a MEDICIN
7001 a Sun, Xiao-Feng,d 1959-u Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Onkologi,Onkologiska kliniken US4 aut0 (Swepub:liu)xiasu45
7001 a Tian, Chao4 aut
7001 a Wang, Ling4 aut
7001 a Yu, Yong-Yang4 aut
7001 a Zhou, Bing4 aut
7001 a Gu, Jun4 aut
7001 a Xia, Qing-Jie4 aut
7001 a Li, Yuan4 aut
7001 a Wang, Rong4 aut
7001 a Zheng, Xue-Lian4 aut
7001 a Zhou, Zong-Guang4 aut
7102 a Linköpings universitetb Hälsouniversitetet4 org
7730 t Oncologyd : S. Karger AGg 72:1-2, s. 82-88q 72:1-2<82-88x 0890-9091x 0030-2414x 1423-0232
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-40458
8564 8u https://doi.org/10.1159/000111107

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