Sökning: WFRF:(Liao Wei Ting)
> (2020-2021) >
Mono-(2-ethylhexyl)...
Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses
-
- Lin, Chun-Yu (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Anestesiologi och intensivvård,Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med,Grad Inst Med, Kaohsiung, Taiwan
-
- Huang, Chung-Hao (författare)
- Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Grad Inst Med, Kaohsiung, Taiwan
-
- Wang, Wen-Hung (författare)
- Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Grad Inst Med, Kaohsiung, Taiwan
-
visa fler...
-
- Tenhunen, Jyrki (författare)
- Uppsala universitet,Anestesiologi och intensivvård,Institutionen för medicinsk biokemi och mikrobiologi
-
- Hung, Ling-Chien (författare)
- Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Grad Inst Med, Kaohsiung, Taiwan
-
- Lin, Chi-Chou (författare)
- Kaohsiung Med Univ, Coll Biomed Sci, Dept Biotechnol, Kaohsiung, Taiwan
-
- Chen, Yu-Cheng (författare)
- Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Grad Inst Med, Kaohsiung, Taiwan
-
- Chen, Yen-Hsu (författare)
- Kaohsiung Med Univ, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Grad Inst Med, Kaohsiung, Taiwan; Kaohsiung Municipal Tatung Hosp, Dept Internal Med, Kaohsiung, Taiwan; Natl Chiao Tung Univ, Coll Biol Sci & Technol, Dept Biol Sci & Technol, Hsinchu, Taiwan
-
- Liao, Wei-Ting (författare)
- Kaohsiung Med Univ, Coll Biomed Sci, Dept Biotechnol, Kaohsiung, Taiwan; Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan; Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan
-
visa färre...
-
(creator_code:org_t)
- 2021-02-15
- 2021
- Engelska.
-
Ingår i: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 12
- Relaterad länk:
-
https://doi.org/10.3...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://www.frontier...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
visa färre...
Abstract
Ämnesord
Stäng
- Exposure to environmental hormones such as di(2-ethylhexyl) phthalate (DEHP) has become a critical human health issue globally. This study aimed to investigate the correlations between DEHP/mono-(2-ethylhexyl) phthalate (MEHP) levels and macrophage-associated immune responses and clinical manifestations in dengue virus (DV)-infected patients. Among 89 DV-infected patients, those with DV infection-related gastrointestinal (GI) bleeding (n = 13, 15% of patients) had significantly higher DEHP exposure than those without GI bleeding (n = 76, 85% of patients), which were 114.2 ng/ml versus 52.5 ng/ml ΣDEHP in urine; p = 0.023). In an in vitro study using cultured human monocyte-derived macrophages (MDMs) to investigate the effects of MEHP, treatment increased IL-1β and TNF-α release but decreased IL-23 release, with negative correlations observed between urine ΣDEHP and serum IL-23 levels in patients. MEHP-treated MDMs had lower antiviral Th17 response induction activity in mixed T-cell response tests. The in vitro data showed that MEHP increased DV viral load and decreased IL-23 release dose-dependently, and adding IL-23 to MEHP-exposed MDMs significantly reduced the DV viral load. MEHP also suppressed IL-23 expression via the peroxisome proliferator-activated receptor-gamma (PPAR-γ) pathway. Further, the PPAR-γ antagonist GW9662 significantly reversed MEHP-induced IL-23 suppression and reduced the DV viral load. These study findings help to explain the associations between high MEHP levels and the high global burden of dengue disease.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- phthalate
- dengue virus
- macrophage
- IL-23
- biological sciences
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas