SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Lillycrop Karen)
 

Sökning: WFRF:(Lillycrop Karen) > Epigenome-wide asso...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005090naa a2200709 4500
001oai:DiVA.org:umu-154848
003SwePub
008190107s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1548482 URI
0247 a https://doi.org/10.1038/s41366-018-0064-72 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Campanella, Gianluca4 aut
2451 0a Epigenome-wide association study of adiposity and future risk of obesity-related diseases
264 c 2018-05-01
264 1b Nature Publishing Group,c 2018
338 a print2 rdacarrier
520 a Background: Obesity is an established risk factor for several common chronic diseases such as breast and colorectal cancer, metabolic and cardiovascular diseases; however, the biological basis for these relationships is not fully understood. To explore the association of obesity with these conditions, we investigated peripheral blood leucocyte (PBL) DNA methylation markers for adiposity and their contribution to risk of incident breast and colorectal cancer and myocardial infarction.Methods: DNA methylation profiles (Illumina Infinium® HumanMethylation450 BeadChip) from 1941 individuals from four population-based European cohorts were analysed in relation to body mass index, waist circumference, waist-hip and waistheight ratio within a meta-analytical framework. In a subset of these individuals, data on genome-wide gene expression level, biomarkers of glucose and lipid metabolism were also available. Validation of methylation markers associated with all adiposity measures was performed in 358 individuals. Finally, we investigated the association of obesity-related methylation marks with breast, colorectal cancer and myocardial infarction within relevant subsets of the discovery population.Results: We identified 40 CpG loci with methylation levels associated with at least one adiposity measure. Of these, one CpG locus (cg06500161) in ABCG1 was associated with all four adiposity measures (P=9.07×10−8 to 3.27×10−18) and lower transcriptional activity of the full-length isoform of ABCG1 (P=6.00×10−7), higher triglyceride levels (P=5.37×10−9) and higher triglycerides-to-HDL cholesterol ratio (P=1.03×10−10). Of the 40 informative and obesity-related CpG loci, two (in IL2RB and FGF18) were significantly associated with colorectal cancer (inversely, P<1.6×10−3) and one intergenic locus on chromosome 1 was inversely associated with myocardial infarction (P<1.25×10−3), independently of obesity and established risk factors.Conclusion: Our results suggest that epigenetic changes, in particular altered DNA methylation patterns, may be an intermediate biomarker at the intersection of obesity and obesity-related diseases, and could offer clues as to underlying biological mechanisms.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Gunter, Marc J.4 aut
7001 a Polidoro, Silvia4 aut
7001 a Krogh, Vittorio4 aut
7001 a Palli, Domenico4 aut
7001 a Panico, Salvatore4 aut
7001 a Sacerdote, Carlotta4 aut
7001 a Tumino, Rosario4 aut
7001 a Fiorito, Giovanni4 aut
7001 a Guarrera, Simonetta4 aut
7001 a Iacoviello, Licia4 aut
7001 a Bergdahl, Ingvaru Umeå universitet,Enheten för biobanksforskning4 aut0 (Swepub:umu)inbe0001
7001 a Melin, Beatriceu Umeå universitet,Onkologi4 aut0 (Swepub:umu)bema0010
7001 a Lenner, Peru Umeå universitet,Onkologi4 aut0 (Swepub:umu)pele0005
7001 a de Kok, Theo M. C. M.4 aut
7001 a Georgiadis, Panagiotis4 aut
7001 a Kleinjans, Jos C. S.4 aut
7001 a Kyrtopoulos, Soterios A.4 aut
7001 a Bueno-de-Mesquita, H. Bas4 aut
7001 a Lillycrop, Karen A.4 aut
7001 a May, Anne M.4 aut
7001 a Onland-Moret, N. Charlotte4 aut
7001 a Murray, Robert4 aut
7001 a Riboli, Elio4 aut
7001 a Verschuren, Monique4 aut
7001 a Lund, Eiliv4 aut
7001 a Mode, Nicolle4 aut
7001 a Sandanger, Torkjel M.4 aut
7001 a Fiano, Valentina4 aut
7001 a Trevisan, Morena4 aut
7001 a Matullo, Giuseppe4 aut
7001 a Froguel, Philippe4 aut
7001 a Elliott, Paul4 aut
7001 a Vineis, Paolo4 aut
7001 a Chadeau-Hyam, Marc4 aut
7102 a Umeå universitetb Enheten för biobanksforskning4 org
7730 t International Journal of Obesityd : Nature Publishing Groupg 42:12, s. 2022-2035q 42:12<2022-2035x 0307-0565x 1476-5497
8564 u https://eprints.soton.ac.uk/421868/1/34501_2_merged_1517388057_1.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154848
8564 8u https://doi.org/10.1038/s41366-018-0064-7

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy