WFRF:(Lin Jian)
Sökning: WFRF:(Lin Jian) > (2000-2004) > Islet insulin secre...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03926nam a2200577 4500 | |
| 001 | oai:DiVA.org:uu-2989 | |
| 003 | SwePub | |
| 008 | 021121s2002 | |||||||||||000 ||eng| | |
| 020 | a 9155454674q print | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-29892 URI |
| 040 | a (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a dok2 swepub-publicationtype |
| 100 | 1 | a Lin, Jian-Man,d 1961-u Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut |
| 245 | 1 0 | a Islet insulin secretory patterns in diabetes and the role of UCP2 |
| 264 | 1 | a Uppsala :b Acta Universitatis Upsaliensis,c 2002 |
| 300 | a 37 s. | |
| 338 | a electronic2 rdacarrier | |
| 490 | 0 | a Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine,x 0282-7476 ;v 1207 |
| 520 | a During development of type 1 and type 2 diabetes plasma insulin patterns are altered. Since the islet insulin release pattern has been implicated in this development, insulin secretion from single islets was studied and linked to the islet protein levels of uncoupling protein-2 (UCP2). Islets were isolated from NOD- and KKAy- mice, GK- and GK-derived congenic rats, which are animal models of diabetes, and three human subjects with type 2 diabetes. At basal glucose (3 mM), insulin release from such islets was pulsatile and the amount released was comparable to that of control islets. When the glucose concentration was raised to 11 mM insulin release was essentially unchanged in islets isolated from older NOD- and KKAy- mice, GK- and Niddm1i congenic rats, and NIDDM persons. In islets from Niddm1f congenic rats, younger NOD- and KKAy-mice, control animals and normal human donors the secretion rate increased 2-9 fold when the glucose concentration was raised. This rise in secretion was manifested as increase of the amplitude of the insulin oscillations without affecting their frequency. Impaired glucose-induced insulin release was associated with reduction in glucose oxidation measured in NOD-islets, unaffected respiration measured in GK-islets and higher protein level of UCP2 measured in KKAy-islets. When the UCP2 amounts in KKAy-islets were reduced by culture to those of control islets, glucose-induced insulin secretion was essentially normalized. Our studies suggest that the deranged plasma insulin patterns observed in diabetes are related to decrease in the amplitude of insulin oscillations from the islets rather than loss of the oscillatory activity. This reduction of pulse amplitude may be related to impaired glucose metabolism and/or increased mitochondrial uncoupling. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
| 653 | a Cell biology | |
| 653 | a type 1 diabetes | |
| 653 | a type 2 diabetes | |
| 653 | a NOD | |
| 653 | a GK | |
| 653 | a congenes | |
| 653 | a KKAy | |
| 653 | a human | |
| 653 | a islet | |
| 653 | a glucose | |
| 653 | a insulin release | |
| 653 | a oscillation | |
| 653 | a frequency | |
| 653 | a amplitude | |
| 653 | a oxidation | |
| 653 | a respiration | |
| 653 | a UCP2 | |
| 653 | a western blot | |
| 653 | a Cellbiologi | |
| 653 | a Cell biology | |
| 653 | a Cellbiologi | |
| 653 | a medicinsk cellbiologi | |
| 653 | a Medical Cell Biology | |
| 700 | 1 | a Grill, Valdemar,c professoru Dept of Medicine,Section Endocrinology,University Hospital of Trondheim, Trondheim4 opn |
| 710 | 2 | a Uppsala universitetb Institutionen för medicinsk cellbiologi4 org |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:162180/FULLTEXT01.pdfx primaryx Raw objecty fulltext |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2989 |
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